Epidemiology and economic impact of varicella in immunocompetent children in Spain.

Díez‐Domingo, Javier; Arı́stegui, Javier; Calbo, Francisco; González-Hachero, José; Moraga, Fernando A.; Guitian, J. Peña; Ruiz–Contreras, Jesús; Torrellas, Annhymariet

doi:10.1016/s0264-410x(03)00264-0

Cited by 27 publications

(35 citation statements)

References 13 publications

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“…Annual incidence in the past ten years ranged from Abbreviations: URV, universal routine vaccination; CLIA, ChemiLuminescent ImmunoAssay; VZV, varicella zoster virus; GMT, Geometric Mean Titre. 300 per 100,000 population in western Europe [3,4] to 164-1240 per 100,000 population in southern Europe [5][6][7][8][9][10][11][12][13][14][15][16][17] and 350 per 100,000 population in eastern Europe [18,19]. The annual incidence among children 1-4 years old was of 1580-12,124 cases per 100,000 population [9,18,10,20].…”

Section: Introductionmentioning

confidence: 99%

A seroprevalence survey on varicella among adults in the vaccination era in Apulia (Italy)

Tafuri

Gallone

Cappelli

et al. 2014

Vaccine

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Section: Introductionmentioning

confidence: 99%

A seroprevalence survey on varicella among adults in the vaccination era in Apulia (Italy)

Tafuri

Gallone

Cappelli

et al. 2014

Vaccine

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“…17,19,23 Unfortunately, no such data are available from other out-patient studies which focused on hospitalization rates rather than individual disease characteristics. 13,14,18 Virtually all complications occurred in previously healthy young children, although the complication rate due to varicella is known to increase by age.…”

Section: Discussionmentioning

confidence: 99%

“…5,[13][14][15][16] In contrast, less data on the clinical impact of varicella are available in the ambulatory setting and no data have been generated for Switzerland so far. 13,[17][18][19] The goal of our study therefore was to collect data on varicella-associated morbidity in ambulatory patients in Switzerland as a basis for the discussion of future national immunization recommendations. We aimed to collect real-life data on the clinical outcomes, medical management, and resource utilization in patients with varicella.…”

Section: Introductionmentioning

confidence: 99%

Prospective surveillance of varicella-zoster virus infections in an out-patient setting in Switzerland

Iseli¹,

Aebi²,

Banz³

et al. 2009

Human Vaccines

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“…It mainly affects children with especially winter/spring seasonality: It is estimated that 52%-78% of all reported cases of varicella occur in children aged < 6 years, and 89%-96% of cases in children aged < 14 years; only 5%-7% of cases occur in adults [5,94,95] . The population incidence is about 1300-1600 cases per 100000 inhabitants per year [87] , but varies with geographical location: It is 300-1291 cases per 100000 in Western Europe [96][97][98] , 164-1240 cases per 100000 in Southern Europe [99][100][101][102][103][104][105][106][107][108][109][110][111] , 350 cases per 100000 in Eastern Europe [112,113] , and 1500-1600 cases per 100000 in the United States (prevaccine era) [114] . The reported mortality rate is 0.04-0.06 per 100000 inhabitants, and 2-4 per 100000 cases of varicella, including 35% of adult cases [5,30,[115][116][117][118][119][120][121] .…”

Section: Epidemiologymentioning

confidence: 99%

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

Paschale

Clerici

2016

WJV

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Varicella-zoster virus, which is responsible for varicella (chickenpox) and herpes zoster (shingles), is ubiquitous and causes an acute infection among children, especially those aged less than six years. As 90% of adults have had varicella in childhood, it is unusual to encounter an infected pregnant woman but, if the disease does appear, it can lead to complications for both the mother and fetus or newborn. The major maternal complications include pneumonia, which can lead to death if not treated. If the virus passes to the fetus, congenital varicella syndrome, neonatal varicella (particularly serious if maternal rash appears in the days immediately before or after childbirth) or herpes zoster in the early years of life may occur depending on the time of infection. A Microbiology laboratory can help in the diagnosis and management of mother-child infection at four main times: (1) when a pregnant woman has been exposed to varicella or herpes zoster, a prompt search for specific antibodies can determine whether she is susceptible to, or protected against infection; (2) when a pregnant woman develops clinical symptoms consistent with varicella, the diagnosis is usually clinical, but a laboratory can be crucial if the symptoms are doubtful or otherwise unclear (atypical patterns in immunocompromised subjects, patients with post-vaccination varicella, or subjects who have received immunoglobulins), or if there is a need for a differential diagnosis between varicella and other types of dermatoses with vesicle formation; (3) when a prenatal diagnosis of uterine infection is required in order to detect cases of congenital varicella syndrome after the onset of varicella in the mother; and (4) when the baby is born and it is necessary to confirm a diagnosis of varicella (and its complications), make a differential diagnosis between varicella and other diseases with similar symptoms, or confirm a causal relationship between maternal varicella and malformations in a newborn. Core tip: Although varicella during pregnancy is infrequent and congenital varicella syndrome (CVS) is rare, every available means should be used to prevent and diagnose them. Microbiology laboratories can be crucial in these situations: Evaluating a mother's immune status with sensitive and specific tests for the detection of antibodies; allowing a rapid diagnosis with molecular biology tests when a clinical manifestation may be due to different etiologies; following pregnant women with varicella for the prenatal diagnosis of CVS with close collaboration between molecular biology investigators and specialists in imaging diagnostics.De Paschale M, Clerici P. Microbiology laboratory and the management of mother-child varicella-zoster virus infection. World

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Epidemiology and economic impact of varicella in immunocompetent children in Spain.

Cited by 27 publications

References 13 publications

A seroprevalence survey on varicella among adults in the vaccination era in Apulia (Italy)

A seroprevalence survey on varicella among adults in the vaccination era in Apulia (Italy)

Prospective surveillance of varicella-zoster virus infections in an out-patient setting in Switzerland

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

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