Epidemiology and Elimination of HCV-Related Liver Disease

Pradat, Pierre; Virlogeux, Victor; Trépo, Eric

doi:10.3390/v10100545

Cited by 54 publications

(38 citation statements)

References 104 publications

(143 reference statements)

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“…24 In addition, the rate of treated patients with HCV can be very low in the community can. 25 It is thought that HCV infection rate decreases with antiviral treatments, but more time is required for decreasing HCC rates. 26 The most striking feature of present study was the significant increase in NASH among the causes of HCC 2013 and later.…”

Section: Resultsmentioning

confidence: 99%

Trends of etiology and treatment in hepatocellular carcinoma over the years

Vatansever

Paköz²

2018

Int J Res Med Sci

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Background: HCC has been the fastest-growing cause of cancer-related deaths. The aim of this study was to investigate the change trends in the etiology, treatment and mortality of HCC over the last 12 years.Methods: The study included 523 patients who were admitted to our clinic with the diagnosis of primary malignancy of the liver between 2006-2018. Demographic data, HCC etiologies, alpha feto-protein (AFP) values and imaging characteristics were recorded. The patients were divided into two groups as diagnosed before 2013 and 2013 and later. Because the number of patients with alcohol and HBV was high, it was evaluated as a separate etiology group. HCC was accepted related to NASH in the patients with obesity and diabetes mellitus (DM) after exclusion of HBV, HCV, and autoimmune hepatitis. The patients without obesity and DM were accepted as cryptogenic HCC and added to other etiologies group.Results: When the patients were evaluated, there was a significant increase in the rate of patients who were in compensated cirrhosis stage and in UCSF criteria in and 2013 and later (p = 0.0001, p = 0.037, respectively). A significant increase was observed in the ratio of NASH-related HCC 2013 and later (p = 0.032). Transplantation, resection and RFA / PEI rates were 14.9% before 2013 and 22.2% 2013 and later (p = 0.047).Conclusions: The rates of NAFLD related HCC due to diabetes and obesity are increasing. Knowing the change of HCC causes over the years is necessary for the effective treatment for these reasons in the future.

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Section: Resultsmentioning

confidence: 99%

Trends of etiology and treatment in hepatocellular carcinoma over the years

Vatansever

Paköz²

2018

Int J Res Med Sci

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“…The advent of DAA agents in patients with HCV allows a virological cure in more than 95% of treated patients, and therefore high rates of decreases of HCV-related complications are also expected in the real-world clinical practice [41,42]. The mechanism for the decreased serum Zn level in HCV-related LC is presumed to involve the non-structural (NS) proteins 3 (NS3, Zn-containing enzyme) and NS5A (Zn metalloprotein) of HCV, but the serum Zn concentration itself may not be affected by the HCV genotype and HCV viral load [43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Serum Zinc Level Grading System: A Useful Model for Composite Hepatic Events in Hepatitis C Virus-Associated Liver Cirrhosis

Nishikawa

Enomoto

Iwata

et al. 2020

JCM

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We aimed to clarify the impact of the serum zinc (Zn) level grading system proposed by the Japanese society of clinical nutrition (JSCN: 80 μg/dL ≤ serum Zn level < 130 μg/dL (type A), 60 μg/dL ≤ serum Zn level < 80 μg/dL (type B), and serum Zn level < 60 μg/dL (type C)) in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC) on the incidence of composite hepatic events (Com-HEs) compared with Child–Pugh (C–P) classification or albumin-bilirubin (ALBI) grade. (n = 275, median age = 67 years). The Akaike information criterion (AIC) was compared among three prognostic models. Factors associated with the incidence of Com-HEs were also studied. The first incidence of any HE was confirmed in 112 patients (40.7%). The AIC value for Com-HEs by the Zn level grading system was the lowest among the three prognostic models (AIC: 301.788 in Zn level grading system, 303.372 in ALBI grade, and 333.953 in C–P classification). In the multivariate analysis, male (p = 0.0031), ALBI grade 3 (p = 0.0041), type B (p = 0.0238), type C (p = 0.0004), and persistent viremia (p < 0.0001) were significant factors associated with the incidence of Com-HEs. In conclusion, the serum Zn level grading system proposed by JSCN can be helpful for estimating the incidence of Com-HEs in HCV-related LC patients.

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“…Drug injection is the most important risk factor for the acquisition of HCV infection in large urban centers, especially in young individuals. In addition, the high prevalence in satellite cities may be explained by the large influx of migrants 15,24,28,29 .…”

Section: Discussionmentioning

confidence: 99%

Ecological study of viral hepatitis in Brazil: A geographical and temporal analysis

et al. 2019

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Introduction: Viral hepatitis is a group of diseases that present high hepatotropism and are related to liver dysfunctions, having either an acute or a chronic course. Their worldwide epidemiology is diverse, with several endemic places, such as South America. The objective of this study was to analyze the epidemiology of viral hepatitis in Brazil, in order to better understand its pattern of distribution and evolution. Method: A temporal aggregation study was conducted using the Viral Hepatitis Database of the Brazilian Ministry of Health. The serological markers used were HBsAg and anti-HCV for hepatitis B and C, respectively. Mortality data were collected from the Mortality Information System for deaths attributed to viral hepatitis. The period analyzed was from 2007 to 2016/17. Results: The incidence was 7.88 (95% CI, 7.30-8.45) for hepatitis B and 11.9 (95% CI, 11.15-12.65) for hepatitis C. Mortality attributed to viral hepatitis was 1.61 (95% CI, 1.35-1.87) deaths per 100,000 people. An analysis of municipal distribution data showed several endemic areas. The Brazilian regions most affected by hepatitis B virus were the northern and southern borders, Santa Catarina coast and Espírito Santo state, while hepatitis C virus was mostly present in metropolitan areas such as Porto Alegre and São Paulo. Conclusions: Viral hepatitis has a diverse geographic distribution in the Brazilian territory, with highly endemic areas. The distribution differs between hepatitis B and hepatitis C viruses.

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Epidemiology and Elimination of HCV-Related Liver Disease

Cited by 54 publications

References 104 publications

Trends of etiology and treatment in hepatocellular carcinoma over the years

Trends of etiology and treatment in hepatocellular carcinoma over the years

Serum Zinc Level Grading System: A Useful Model for Composite Hepatic Events in Hepatitis C Virus-Associated Liver Cirrhosis

Ecological study of viral hepatitis in Brazil: A geographical and temporal analysis

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