Epidemiology and Familial Risk of Synchronous and Metachronous Colorectal Cancer: A Population-based Study in Utah

Samadder, Jewel; Curtin, Karen; Wong, Jathine; Pappas, Lisa M.; Tuohy, Thérèse M.F.; Mineau, Geraldine P.; Smith, Ken R.; Pimentel, Richard; Boucher, Kenneth M.; Provenzale, Dawn; Burt, Randall W.

doi:10.14309/00000434-201310001-02092

Cited by 14 publications

(24 citation statements)

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“…Among these, 23 studies were conducted in Europe, 17,18,20,[24][25][26]29,31,34,36,37,39,40,42,46,57,59,60,[63][64][65]71,77 18 in the Asia-Pacific nations, 19,23,32,38,45,47,49,50,52,[54][55][56]62,66,70,72,74,76 and 21 in America. 21,22,27,28,30,33,35,41,43,44,48,51,…”

Section: Resultsmentioning

confidence: 99%

Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: A Systematic Review and Meta-Analysis

Roos

Mangas-Sanjuán

Rodríguez-Girondo

et al. 2019

Clinical Gastroenterology and Hepatology

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This article has an accompanying continuing medical education activity, also eligible for MOC credit, on page e159. Learning Objective-Upon completion of this activity, successful learners will be able to identify the risk for developing colorectal cancer (CRC) related to the type of family history; identify the absolute risk for developing colorectal cancer for individuals with at least one first degree relative (FDR) with CRC younger than 50 years; and define "familial colorectal cancer." BACKGROUND & AIMS: Guidelines recommend that individuals with familial colorectal cancer undergo colonoscopy surveillance instead of average-risk screening. However, these recommendations vary widely. To substantiate appropriate surveillance strategies, precise and valid evidence-based risk estimates are needed for individuals with a family history of colorectal cancer (CRC). METHODS: We systematically searched MEDLINE, EMBASE, and Cochrane from inception to July 2018 for case-control and cohort studies investigating the effect of family history on CRC risk. We calculated summary estimates of pooled relative risks (RRs) using a random-effects model. Life tables were created to convert RR estimates into absolute risk estimates. RESULTS: We screened 4417 articles and identified 42 eligible case-control and 20 cohort studies. In case-control studies, the RR for CRC in patients with 1 first-degree relative (FDR with CRC) was 1.92 (95% CI, 1.53-2.41) and 1.37 (95% CI, 0.76-2.46) for cohort studies. For individuals with 2 or more FDRs with CRC, the RR was 2.81 in case-control studies (95% CI, 1.73-4.55) and 2.40 in cohort studies (95% CI, 1.76-3.28). For individuals having a FDR diagnosed with CRC at an age younger than 50 years, the RR for CRC in their FDRs was 3.57 in case-control studies (95% CI, 1.07-11.85) and 3.26 in cohort studies (95% CI, 2.82-3.77). The cumulative absolute risks for CRC at 85 years in Western Europe were 4.8% for persons with 1 FDR with CRC (95% CI, 2.7%-8.3%), 8.2% for individuals with 2 or more FDRs (95% CI, 6.1%-10.9%), and 11% for persons with a FDR diagnosed with CRC at an age younger than 50 years (95% CI, 9.5%-12.4%). CONCLUSIONS: In this systematic review and meta-analysis, we found that the RR of CRC among FDRs is lower than previously expected, especially based on cohort studies. Risk estimates are affected by the number of relatives with CRC and their age at diagnosis. Intensified colonoscopy surveillance strategies could be considered for high-risk groups. PROSPERO trial identification no: CRD42018103058.

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Section: Resultsmentioning

confidence: 99%

Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: A Systematic Review and Meta-Analysis

Roos

Mangas-Sanjuán

Rodríguez-Girondo

et al. 2019

Clinical Gastroenterology and Hepatology

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“…Data from population-based registries suggest that metachronous CRCs are being diagnosed at earlier stages, possibly reflecting the effect of increased surveillance. 48,65 The cumulative incidence of metachronous cancers of the colon and rectum is estimated to be about 0.3%À0.35% per year, 5,60,66 presenting at any time, even decades after the index malignancy. 4,[18][19][20]39,[41][42][43]45,55,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] All colorectal segments are at increased risk for a metachronous cancer, although some studies suggest that among older survivors, the risk remains elevated only in the proximal colon.…”

Section: Colonoscopy and Prevention Of Metachronous Cancer After Surgmentioning

confidence: 99%

Colonoscopy surveillance after colorectal cancer resection: recommendations of the US multi-society task force on colorectal cancer

Kahi

Boland

Dominitz

et al. 2016

Gastrointestinal Endoscopy

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TABLE 1. Grading of recommendations assessment, development, and evaluation ratings of evidence Rating of evidence Definition A: High quality Further research is very unlikely to change our confidence in the estimate of effect B: Moderate quality Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate C: Low quality Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate D: Very low quality Any estimate of effect is very uncertain Colonoscopy surveillance after CRC resection

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“…In patients with CRC, the prevalence of synchronous cancers ranges from 0.7% % to about 7%. [39][40][41][42][43][44][45][46][47][48] Colonoscopy is preferably performed preoperatively 49 ; however, it can be deferred for 3 to 6 months postoperatively if colonoscopy is incomplete due to malignant obstruction. The 3-month lower limit is intended to provide patients with sufficient time for postoperative recovery.…”

Section: Colonoscopy and Perioperative Clearing In Patients With Cancmentioning

confidence: 99%

Section: Colonoscopy and Prevention Of Metachronous Cancer After Surgmentioning

confidence: 99%

Colonoscopy Surveillance After Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer

et al. 2016

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The US Multi-Society Task Force has developed updated recommendations to guide health care providers with the surveillance of patients after colorectal cancer (CRC) resection with curative intent. This document is based on a critical review of the literature regarding the role of colonoscopy, flexible sigmoidoscopy, endoscopic ultrasound, fecal testing and CT colonography in this setting. The document addresses the effect of surveillance, with focus on colonoscopy, on patient survival after CRC resection, the appropriate use and timing of colonoscopy for perioperative clearing and for postoperative prevention of metachronous CRC, specific considerations for the detection of local recurrence in the case of rectal cancer, as well as the place of CT colonography and fecal tests in post-CRC surveillance.

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Epidemiology and Familial Risk of Synchronous and Metachronous Colorectal Cancer: A Population-based Study in Utah

Cited by 14 publications

References 0 publications

Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: A Systematic Review and Meta-Analysis

Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: A Systematic Review and Meta-Analysis

Colonoscopy surveillance after colorectal cancer resection: recommendations of the US multi-society task force on colorectal cancer

Colonoscopy Surveillance After Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer

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