Epidemiology and genotypic diversity of canine circovirus identified in pet dogs in Harbin, China

Lv, Zhi-Hang; Lian, Chun-Yang; Li, Changle; Chui, Wenting; Yao, Xin-Yan; Shao, Jian‐Wei; Zhang, Xuelian

doi:10.1016/j.actatropica.2023.106978

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…In China, CanineCV infections have been reported in domestic dogs in the Guangxi and Heilongjiang Provinces between 2014 and 2016 with an average prevalence of 8.75 and 12.8% respectively ( 8 , 13 ). Subsequently, Lv et al ( 14 ) investigated the ongoing prevalence of CanineCV in Heilongjiang analyzing the samples collected between 2019 and 2020. The study revealed a positivity rate of 9.5% during this period, which was lower than that observed between 2014 and 2016.…”

Section: Discussionmentioning

confidence: 99%

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Identification and characterization of a novel canine circovirus with truncated replicate protein in Sichuan, China

Cao,

Li,

Xin

et al. 2024

Front. Vet. Sci.

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Canine circovirus (CanineCV) is a recently identified member of the Circoviridae family. Since its discovery in 2011, CanineCV has been detected in different countries worldwide, infecting both domestic and wild canids. The virus is potentially associated with gastrointestinal and respiratory illnesses. In 2016, CanineCV was reported in the southwestern region of Guangxi, China. However, its prevalence in other provinces in the Southwest region remained unknown. This study collected a total of 208 serum samples from domestic dogs in Sichuan, China in 2022 to investigate the prevalence of CanineCV. Among these samples, 26 tested positive for CanineCV, resulting in a positivity rate of 12.5%. Additionally, 12 strains were sequenced, 9 of which had a sequence length of 2,063 nucleotides (nt), 2 of the other threes had a length of 2,062 nts and another was 2,064 nt. Notably, a frameshift mutation was identified, resulting in a truncated ORF1 and the occurrence of a novel sequence comprised of 13 amino acids at the end of the replicate protein (Rep). This mutation could affect the replication cycle of the virus. Phylogenetic and evolutionary analyses revealed that the isolates belonged to the CanineCV-3 genotype and were prevalent in the Southeast and the Southwest regions of China, as well as in the neighboring countries alongside other strains of the same genotype. Collectively, this epidemiological investigation widens our understanding of the genetic diversity of CanineCV in Southwest China and provides insights into viral evolution.

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Section: Discussionmentioning

confidence: 99%

“…This underscores the genetic diversity of circoviruses circulating in dogs globally. Genotypes of canineCV-2, -3, and -4 are widespread in domestic dogs in China ( 14 ). The co-circulation of various genotypes of CanineCV in dogs may facilitate the occurrence of recombinant viruses.…”

Section: Discussionmentioning

confidence: 99%

Identification and characterization of a novel canine circovirus with truncated replicate protein in Sichuan, China

Cao,

Li,

Xin

et al. 2024

Front. Vet. Sci.

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Novel genotyping definition and molecular characteristics of canine circovirus in China

Ji,

Jiao,

Zhang

et al. 2024

Virology

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Epidemiological and evolutionary analysis of canine circovirus from 1996 to 2023

Liu,

Qin,

et al. 2024

BMC Vet Res

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Background Canine circovirus (CanineCV), a non-enveloped virus with a circular DNA genome, has been identified in various avian and mammalian species, including domestic and wild canids. This study aimed to comprehensively analyze the prevalence of CanineCV across diverse animal species in 11 provinces of China. Results A total of 1,666 serum samples were collected, revealing a 5.82% prevalence of CanineCV in dogs, with the highest rates being observed in southern and eastern China. Phylogenetic analysis of 266 global CanineCV genomes sourced from the NCBI identified six distinct genotypes, elucidating the complex dynamics of their evolution. Evidence suggested a potential bat origin for CanineCV, with positive selection and high rates of evolution being observed. Recombination analysis revealed dynamic genetic exchange, highlighting the intricate nature of CanineCV evolution. Mutational analysis identified key amino acid substitutions likely to influence the virus’s adaptation. Additionally, glycosylation, palmitoylation, and SUMOylation sites were predicted, shedding light on crucial functional properties of the virus. Conclusions This study provides a global perspective on the origin, genetic diversity, and evolutionary dynamics of CanineCV. Understanding these factors is crucial for elucidating its epidemiology and potential health risks.

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Epidemiology and genotypic diversity of canine circovirus identified in pet dogs in Harbin, China

Cited by 3 publications

References 30 publications

Identification and characterization of a novel canine circovirus with truncated replicate protein in Sichuan, China

Identification and characterization of a novel canine circovirus with truncated replicate protein in Sichuan, China

Novel genotyping definition and molecular characteristics of canine circovirus in China

Epidemiological and evolutionary analysis of canine circovirus from 1996 to 2023

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