Epidemiology and Impact of Low-Back Pain

Kelsey, J L; White, Augustus A.

doi:10.1097/00007632-198003000-00007

Cited by 439 publications

(156 citation statements)

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“…It has been estimated that herniated disc disease could be present in 4% to 12% of patients with low back pain and could affect 5% of adults, according to population-based surveys. [5][6][7][8][9] Sciatica symptoms are very persistent in nature over time, and up to one third of all such patients undergo lumbar surgery. neurological function.…”

Section: Introductionmentioning

confidence: 99%

Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study

et al. 2010

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CONTEXT AND OBJECTIVE: The role of immune response and proinflammatory cytokines in the pathogenesis of chronic pain has been of growing interest. In order to evaluate whether there is any association between disc herniation and elevated cytokine levels, we measured cytokine levels in patients with chronic low back pain and in healthy subjects. DESIGN AND SETTING:Analytical cross-sectional study at the Pain Clinic of Universidade Federal da Bahia (UFBA). METHODS:Cytokine levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique on 23 patients with low back pain (G1) and on 10 healthy subjects (G2). RESULTS:The levels of tumor necrosis factor-alpha [TNF-alpha] (G1 = 5.6 ± 2.3 pg/ml; G2 = 1.6 ± 0.5 pg/ml; P = 0.01) and interleukin-6[IL-6] (G1 = 4.1 ± 3.0 pg/ml; G2 = 0.9 ± 0.4 pg/ml; P = 0.01) were higher in G1. There were no statistically significant differences in relation to interleukin-1 [IL-1] (G1 = 0.5 ± 0.3 pg/ml; G2 = 0.5 ± 0.1 pg/ml; P = 1) or soluble tumor necrosis factor receptor [sTNF-R] (G1 = 572 pg/ml ± 36; G2 = 581 ± 50 pg/ml; P = 0.87). CONCLUSION:The patients with chronic low back pain due to disc herniation presented higher levels of TNF-alpha and IL-6, but not of IL-1 or sTNF-R. RESUMO CONTEXTO E OBJETIVO:A função da resposta imunológica e das citocinas pró-inflamatórias na patogênese da dor crônica tem tido interesse crescente. Para avaliar se há correlação entre hérnia de disco e aumento de citocinas, foi medida a concentração de citocinas em pacientes com lombalgia crônica e em indivíduos sadios. TIPO DE ESTUDO E LOCAL: Estudo transversal analítico realizado na Clínica de Dor da Universidade Federal da Bahia (UFBA).MÉTODO: As concentrações de citocinas foram medidas pela técnica de ELISA (enzyme linked immunosorbent assay) em 23 pacientes com lombalgia (G1) e 10 sadios (G2). RESULTADOS:As concentrações de fator-alfa de necrose tumoral [TNF-alpha] (G1 = 5.6 ± 2.3 pg/ml; G2 = 1.6 ± 0.5 pg/ml; P = 0,01) e interleucina-6 [IL-6] (G1 = 4.1 ± 3.0 pg/ml; G2 = 0.9 ± 0.4 pg/ml; P = 0,01) foram maiores no G1. Não houve diferença estatisticamente significante para interleucina-1 [IL-1] (G1 = 0.5 ± 0.3 pg/ml; G2 = 0.5 ± 0.1 pg/ml; P = 1) e receptor solúvel do factor de necrose tumoral [sTNF-R] (G1 = 572 pg/ml ± 36; G2 = 581 ± 50 pg/ml; P = 0,87).CONCLUSÃO: Os pacientes com lombalgia crônica por hérnia de disco apresentam concentrações maiores de TNF-alpha e IL-6, mas não de IL-1 ou sTNF-R.

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Section: Introductionmentioning

confidence: 99%

Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study

et al. 2010

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“…The socioeconomic burden of spinal disorders is steadily increasing. Studies have indicated that 80% of the population experiences back pain during their active lives [10]. Recovery from various spinal conditions depends not only on physical factors, but also on psychological factors [20].…”

Section: Introductionmentioning

confidence: 99%

Do worker's compensation patients with neck pain have lower SF-36 scores?

Hee¹,

Whitecloud²,

Myers³

et al. 2002

Eur Spine J

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“…Three percent of all low back cases in industry will be disabled longer than 3 months [4]. Low back pain is also one of the most costly ailments to society in terms of medical expenses and lost worktime [19]. Leavitt et al [21] found that these costs are skewed with 25% of all low back pain disability claimants accounting for 87% of the costs.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of electroacupuncture and tens in the rehabilitation of chronic low back pain patients

Lehmann¹,

Russell²,

Spratt³

et al. 1986

Pain

173

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SummaryFifty-four patients treated in a 3-week inpatient rehabilitation program were randomly assigned to and accepted treatment with electroacupuncture (n = 17) TENS (low intensity transcutaneous nerve stimulation, n = 18) and TENS deadbattery (placebo, n = 18). Outcome measures included estimates of pain (on a Visual Analogue Scale) and disability by both physician and patient, physical measures of trunk strength and spine range of motion, as well as the patient's perceptions of the relative contribution of the education, exercise training, and the electrical stimulation. Analyses of variance were utilized to determine effects of treatment (electroacupuncture, TENS, placebo) across time (admission, discharge, and return) for the outcome measures. There were no significant differences between treatment groups with respect to their overall rehabilitation. All 3 treatment groups ranked the contribution of the education as being greater than the electrical stimulation. However, the electroacupuncture group consistently demonstrated greater improvement on the outcome measures than the other treatment groups. For the visual analogue scale measure of average pain, there was a statistical trend at the return visit suggesting that the acupuncture group was experiencing less pain.

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Epidemiology and Impact of Low-Back Pain

Cited by 439 publications

References 0 publications

Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study

Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study

Do worker's compensation patients with neck pain have lower SF-36 scores?

Efficacy of electroacupuncture and tens in the rehabilitation of chronic low back pain patients

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