Epidemiology and microbiological profile comparison between community and hospital acquired infections: A multicenter retrospective study in Lebanon

Matta, Roula; Hallit, Souheil; Hallit, Rabih; Bawab, Wafaa; Rogues, Anne-Marie; Salameh, Pascale

doi:10.1016/j.jiph.2017.09.005

Cited by 45 publications

(30 citation statements)

References 27 publications

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“…The present study showed that K pneumoniae isolates were recovered from 42/250 (16.8%) of HAI cases. Similar findings were reported by other researchers . Our strains were recovered from different age groups at nearly the same percentage with the exception of patients <10 years old, where the percentage was much higher (55.9%) and patients >50 years with percentage (27.8%).…”

Section: Discussionsupporting

confidence: 91%

Multidrug‐resistant Klebsiella pneumoniae in hospital‐acquired infections: Concomitant analysis of antimicrobial resistant strains

et al. 2019

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Background Hospital‐acquired infections caused by K pneumoniae are difficult to eradicate since K pneumoniae carries resistance genes for many antimicrobials, including carbapenems. The study aimed to determine the prevalence of hospital‐acquired infections caused by multiple drug‐resistant K pneumoniae and identify carbapenem and fluoroquinolone resistance by phenotypic and genotypic methods amongst hospitalised patients. Methods Two hundred and fifty samples from patients with hospital‐acquired infections were included. Identification and susceptibility testing for K pneumoniae isolates was performed by standard methods. The detection of carbapenemase resistance (blaKPC, blaVIM‐1 and blaOXA‐48) and plasmid‐mediated quinolone resistance (PMQR; qnrA, qnrB and qnrS) genes was performed using PCR assay. Results Out of 250 samples, 42 (16.8%) were multiple drug‐resistant K pneumoniae, and the frequency of K Pneumoniae isolation was higher in urine samples, in the age group (<10 years), in ICU and in patients with longer hospital stay. Twenty‐four (57%) of the isolates were resistant to Meropenem, 13 (31%) were resistant to Imipenem and 35 (83.3%) were resistant to Ciprofloxacin. blaOXA‐48 gene was detected in 9 (21.4%) of isolates, and blaVIM‐1 gene was detected in 6 (14.3%) of isolates. However, no isolate harboured blaKPC gene. PMQR genes were detected in 100% of ciprofloxacin resistant isolates, and qnrS was the dominant. Conclusion Multidrug‐resistant K pneumoniae isolates harbouring blaOXA‐48, blaVIM‐1 and PMQR genes are emerging in hospitals particularly with long hospital stays.

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Section: Discussionsupporting

confidence: 91%

Multidrug‐resistant Klebsiella pneumoniae in hospital‐acquired infections: Concomitant analysis of antimicrobial resistant strains

et al. 2019

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“…In general, it has been shown that the ecological differences in each geographic region can determine the phylogenetic groups involved in UTIs in each region (20). For example, most studies in France and America have reported that most commensal specimens are related to groups A and B1 (24,25) while in this study, they mostly belonged to groups B2 and A. This difference in each region can be affected by antibiotics usage or host genetic factors.…”

Section: Discussionmentioning

confidence: 62%

“…That would probably explain why in this study, the percentage of E. coli isolates in men was noticeably higher in group D than in other phylo-groups. Moreover, it has been established so far that the pathogens causing community-acquired infections are less antibiotic resistant than the ones responsible for nosocomial infections, and vice versa (23,24). Therefore, it would be reasonable to assume that group D might be more virulent than other phylo-groups.…”

Section: Discussionmentioning

confidence: 99%

The relationship between phylogenetic groups and antibiotic susceptibility patterns of Escherichia coli strains isolated from feces and urine of patients with acute or recurrent urinary tract infection

Norouzian

Katouli

Shahrokhi

et al. 2020

IJM

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Background and Objectives: B2 and D have been mentioned as the most common phylogenetic groups among uropatho- genic Escherichia coli. However, there is still controversy about the importance of these phylo-groups. This study was con- ducted to investigate the probable relation between these groups and antibiotic resistance patterns of E. coli isolates derived from urine and feces of the patients with acute or recurrent UTI. Materials and Methods: 10 isolates were recovered from urine and feces samples of patients with different phases of UTI in whom E. coli was causative pathogen. Biochemical fingerprinting was performed to classify the isolates and select their appropriate representatives. Phylogenetic grouping was performed using multiplex PCR, and antibiotic resistance was deter- mined by disk diffusion method. Results: Five-hundred-sixty E. coli isolates were derived from 56 UTI patients (27 acute, 29 recurrent). Among them, 261 isolates were selected using biochemical fingerprinting. All the isolates were sensitive to imipenem and nitrofurantoin. Com- pared to other phylo-groups, the isolates in group D showed considerably different frequencies in acute vs. recurrent phase of UTI, in urine vs. stool samples, in males vs. females, and in- vs. out-patients. They were more resistant to the antibiotics (except norfloxacin), and in contrast to others, this was seen more in acute UTI, especially in urine samples. Multi-drug resistance pattern was also meaningfully higher in group D. Conclusion: Although phylo-groups B2 and D of E. coli bacteria are more responsible for UTI, group D isolates seem to be more resistant and probably more virulent, even than the ones from group B2.

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“…Pseudomonas aeruginosa is a common cause of community-acquired and nosocomial acquired pneumonia and is responsible for 10% of all hospital-acquired infections worldwide (MATTA et al, 2018). The development of resistance of P. aeruginosa to antibiotics is increasing globally due to the overuse of antibiotics (YAYAN et al, 2015).…”

Section: Mechanisms Of Resistence To Antimicrobial Agents In Differenmentioning

confidence: 99%

A review on antibiotic resistance: Origin and mechanisms of bacterial resistance as biological phenomenon

2018

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Antimicrobial resistance is a natural biological phenomenon in their struggle for existence and represents a major health care issue, associated with high mortality and morbidity. The first cases of mass emergence of resistant strains were observed in the middle of the 20th century, and since then cases of resistance have been reported all over the world, and in the last two decades even more frequently are reported multiple bacterial resistance. Factors that contribute to the development of bacteria resistance are abuse in the use of antibacterial agents, in humans or livestock, and releases of antibacterial agents into the environment. Moreover, the development of new effective antibiotics is decreasing, contrary to increasing the overall effort for the synthesis of new ones. Identification and reporting of bacterial resistance, as well as monitoring of the use of antibiotics in the outpatient and inpatient setting, today is the obligation of all countries.

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Epidemiology and microbiological profile comparison between community and hospital acquired infections: A multicenter retrospective study in Lebanon

Cited by 45 publications

References 27 publications

Multidrug‐resistant Klebsiella pneumoniae in hospital‐acquired infections: Concomitant analysis of antimicrobial resistant strains

Multidrug‐resistant Klebsiella pneumoniae in hospital‐acquired infections: Concomitant analysis of antimicrobial resistant strains

The relationship between phylogenetic groups and antibiotic susceptibility patterns of Escherichia coli strains isolated from feces and urine of patients with acute or recurrent urinary tract infection

A review on antibiotic resistance: Origin and mechanisms of bacterial resistance as biological phenomenon

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