Epidemiology and microbiology of Shiga toxin-producing Escherichia coli other than serogroup O157 in England, 2009–2013

Byrne, Lisa; Vanstone, Gemma L.; Perry, Neil T.; Launders, Naomi; Adak, Goutam; Godbole, Gauri; Grant, Kathie; Smith, Robin; Jenkins, Claire

doi:10.1099/jmm.0.075895-0

Cited by 63 publications

(67 citation statements)

References 21 publications

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“…This strain does not possess the pathogenicity factor intimin and the stx2a shiga-toxin subtype which are known to be associated with more severe disease and progression to haemolytic-uraemic syndrome (HUS) [3]. Previous clusters have mainly been travel-associated and limited to around three cases [1].…”

Section: Discussionmentioning

confidence: 99%

“…Such misidentifications are detected when strains are referred for confirmation and typing at the GBRU. Since December 2012, a small number of laboratories, including services in Brighton and central London have adopted polymerase chain reaction (PCR) techniques to detect verocytotoxin genes in stool samples, resulting in an increased number of diagnoses of non-O157 VTEC, including serogroup O117 [3].…”

Section: Discussionmentioning

confidence: 99%

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Identification of verocytotoxin-producing Escherichia coli O117:H7 in men who have sex with men, England, November 2013 to August 2014

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of verocytotoxin-producing Escherichia coli O117:H7 in men who have sex with men, England, November 2013 to August 2014

et al. 2014

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“…The National Reference Laboratory for Enteropathogenic Bacteria (NRL) at the Norwegian Institute of Public Health (NIPH) receives presumptive STEC isolates for verification and characterisation from all the Norwegian medical microbiological laboratories. Historically, laboratories have identified STEC by culturing, with focus on the identification of O157 [3, 11]. In the years following the 2006 outbreak, a majority of medical microbiological laboratories in Norway implemented PCR detection of stx .…”

Section: Introductionmentioning

confidence: 99%

Implementation of multiplex PCR diagnostics for gastrointestinal pathogens linked to increase of notified Shiga toxin-producing Escherichia coli cases in Norway, 2007–2017

Jenssen

Veneti

Lange

et al. 2019

Eur J Clin Microbiol Infect Dis

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The aim of this study was to investigate implementation of multiplex PCR assays (broad screening PCR) on the distribution and characteristics of notified Shiga toxin-producing Escherichia coli (STEC) cases in Norway, 2007–2017. We described STEC cases notified to the Norwegian Surveillance System for Communicable Diseases (MSIS), 2007–2017 and categorised cases as high-virulent, low-virulent or unclassifiable STEC infections based on guidelines for follow-up of STEC cases. We conducted descriptive analysis and time series analysis allowing for trends and seasonality, and calculated adjusted incidence rate ratios (aIRR) using negative binomial regression for laboratories with and without broad screening PCR. A total of 1458 STEC cases were notified to MSIS (2007–2017), median age 21 years, 51% female. Cases were categorised as having 475 (33%) high-virulent, 652 (45%) low-virulent, and 331 (23%) unclassifiable STEC infections. We observed a higher increasing monthly trend in cases (aIRR = 1.020; 95% CI 1.016–1.024) notified from laboratories with broad screening PCR (n = 4) compared to laboratories (n = 17) without (aIRR = 1.011; 95% CI 1.007–1.014). Notification of low-virulent STEC infections increased from laboratories with broad screening PCR. The increase in notified STEC cases was prominent in cases categorised with a low-virulent STEC infection and largely attributable to unselective screening methods. We recommend NIPH to maintain differentiated control measures for STEC cases to avoid follow-up of low-virulent STEC infections. We recommend microbiological laboratories in Norway to consider a more cost-effective broad screening PCR strategy that enables differentiation of high-virulent STEC infections.Electronic supplementary materialThe online version of this article (10.1007/s10096-019-03475-5) contains supplementary material, which is available to authorized users.

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“…via animal contact is less well known. Contact with farm and domestic animals has been identified as a risk factor for VTEC non-O157 [74,75] and Y. enterocolitica, respectively [76]. While the evidence is less clear for L. monocytogenes, transmission from animal to human is plausible, as Listeria has been identified in pet food [77], urban poultry flocks [78] and at least one study identified living on a cattle farm as an increased risk of listeriosis [79].…”

Section: Discussionmentioning

confidence: 99%

Estimates of the burden of illness for eight enteric pathogens associated with animal contact in Canada

et al. 2017

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SUMMARYEnteric pathogens are commonly known to be transmitted through food or water; however, contact with animals is another important transmission route. This study estimated the annual burden of illness attributable to animal contact for eight enteric pathogens in Canada. Using data from a Canadian expert elicitation on transmission routes, the proportion of enteric illnesses attributable to animal contact was estimated for each pathogen to estimate the annual number of illnesses, hospitalizations and deaths in Canada. For each estimate, a mean and probability intervals were generated. Of all illnesses caused by these eight pathogens, 16% were estimated attributable to animal contact. This estimate translates to 86 000 (31 000-166 000) illnesses, 488 (186-890) hospitalizations and 12 (2-28) deaths annually for the eight pathogens combined. Campylobacter spp. is the leading cause of illnesses annually, with an estimated 38 000 (14 000-71 000) illnesses occurring each year, followed by non-typhoidal Salmonella spp. (17 000, 6000-32 000). The majority of hospitalizations were attributable to non-typhoidal Salmonella spp. (36%) and Campylobacter spp. (31%). Non-typhoidal Salmonella spp. (28%) and Listeria monocytogenes (31%) were responsible for the majority of the estimated deaths. These results identify farm animal and pet/pet food exposure as key pathways of transmission for several pathogens. The estimated burden of illness associated with animal contact is substantial.

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Epidemiology and microbiology of Shiga toxin-producing Escherichia coli other than serogroup O157 in England, 2009–2013

Abstract: Epidemiology and microbiology of Shiga toxin-producing Escherichia coli other than serogroup O157 in England, 2009England, -2013

Cited by 63 publications

References 21 publications

Identification of verocytotoxin-producing Escherichia coli O117:H7 in men who have sex with men, England, November 2013 to August 2014

Identification of verocytotoxin-producing Escherichia coli O117:H7 in men who have sex with men, England, November 2013 to August 2014

Implementation of multiplex PCR diagnostics for gastrointestinal pathogens linked to increase of notified Shiga toxin-producing Escherichia coli cases in Norway, 2007–2017

Estimates of the burden of illness for eight enteric pathogens associated with animal contact in Canada

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