Epidemiology and microbiology of skin and soft tissue infections

Esposito, Silvano; Noviello, Silvana; Leone, Sebastiano

doi:10.1097/qco.0000000000000239

Cited by 156 publications

(118 citation statements)

References 34 publications

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“…These bacteria belonging to the ESKAPE group are leading causes of nosocomial infections [22] and represent a major threat in skin-related infections and chronic wounds [48][49][50]. The electrospun fibres showed a highly efficient antimicrobial activity against both bacteria, reaching ~100 % kill against P. aeruginosa and ~77 % kill for S. aureus, after 120 min of cells contact.…”

Section: Discussionmentioning

confidence: 99%

Single step fabrication of antimicrobial fibre mats from a bioengineered protein-based polymer

et al. 2017

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Genetically engineered protein polymers functionalized with bioactive domains offer potential as multifunctional versatile materials for biomedical use. The present work describes the fabrication and characterization of antimicrobial fibre mats comprising the antimicrobial elastin-like recombinamer CM4-A200. The CM4-A200 protein polymer derives from the genetic fusion of the ABP-CM4 antimicrobial peptide from Bombyx mori with 200 repetitions of the pentamer VPAVG. This is the first report on non-crosslinked fibre mats fabricated with an antimicrobial elastin-like recombinamer stable in solution.Thermal gravimetric analysis of CM4-A200 fibre mats shows one single degradation step at temperatures above 300 ºC, with fibres displaying a higher thermal degradation activation. The electrospun CM4-A200 fibres display high antimicrobial activity against Gram-positive and Gram-negative bacteria with no detectable cytotoxic effects against normal human skin fibroblasts and keratinocytes, revealing the great potential of these polymers for the fabrication of biomedical materials.

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Section: Discussionmentioning

confidence: 99%

Single step fabrication of antimicrobial fibre mats from a bioengineered protein-based polymer

et al. 2017

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“…These institutions organize SSTIs by such variables as anatomic location, causative pathogen(s), rate of progression, depth of extension, and clinical presentation or severity [1]. Unfortunately, each has key limitations both in assisting clinical management and in providing guidance for developing new therapeutic agents.…”

mentioning

confidence: 99%

A Proposed New Classification of Skin and Soft Tissue Infections Modeled on the Subset of Diabetic Foot Infection

Lipsky

Silverman²,

Joseph

2016

Open Forum Infectious Diseases

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Schemes for classifying skin and soft tissue infections (SSTIs) pose limitations for clinicians and regulatory agencies. Diabetic foot infections (DFIs) are a subset of SSTIs. We developed and are proposing a classification to harmonize current schemes for SSTIs and DFIs. Existing schemes for classifying SSTIs are limited in both their usefulness to clinicians and to regulatory agencies. The guidelines on SSTI from the Infectious Diseases Society of America (IDSA) and the guidance from the US Food and Drug Administration do not adequately address many types of wound infections. However, guidelines developed by the IDSA for DFIs provide a classification scheme that has been validated and widely used. Diabetic foot infections are similar to SSTIs in pathophysiology, microbiology, and treatment and can be seen as a subset of SSTI. Thus, based on the documents noted above, and our review of the literature, we have developed a proposed classification scheme for SSTI that harmonizes well with the DFI classification. We believe this new scheme will assist clinicians in classifying most wound infections and potentially aid regulatory agencies in testing and approving new antimicrobials for these infections.

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“…There are two principal types of skin flora associated with the hand, namely, resident and transient flora. These microbial and viral floras play a major role in the epidemiology of infections (12). Resident floras are permanent inhabitants of the skin and are found mainly on the surface of the skin.…”

Section: Introductionmentioning

confidence: 99%

Hand washing practices and the occurrence of enteropathogenic bacteria among residents of a Nigerian University

Ayoade¹,

Ardern²

2017

Af J Clin Exp Micro

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Hand washing is known to be an important preventive strategy and a major step in infection control. However, compliance is low in most communities. The present work investigated the relationship between the levels of compliance to hand washing and related this to the occurrence of infectious bacteria in the test population. A questionnaire which contained information on bio-demographic characteristics and hand hygiene practices was applied to 100 individuals in the study population. Microbiological samples were obtained, Total Colony Counts was done and the isolates were identified using standard bacteriological methods. The results showed that 46% of the respondents wash their hands before eating food; 40% of the test population washes their hands after using the toilet; while none of the respondents wash their hands after handling money. The highest bacterial load was found in the 0-15 years age group. The most highly occurring isolate was Salmonella enterica (23.7%). These results confirm the low level of compliance to hand hygiene in the test population and underscores the need to effectively break the fecal-oral transmission route via hands through effective interventions such as hand washing with soap and water.Key Words: enteropathogenic bacteria, hand washing, compliance LES PRATIQUES DE LAVAGE DES MAINS ET L'APPARITION DE BACTERIES ENTEROPATHOGENES PARMI LESRESIDENTS D'UNE UNIVERSITE NIGERIANE.

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Epidemiology and microbiology of skin and soft tissue infections

Abstract: The understanding of the current epidemiology and microbiology of SSTIs is indicated for an appropriate antimicrobial therapy and an overall optimal management of SSTIs.

Cited by 156 publications

References 34 publications

Single step fabrication of antimicrobial fibre mats from a bioengineered protein-based polymer

Single step fabrication of antimicrobial fibre mats from a bioengineered protein-based polymer

A Proposed New Classification of Skin and Soft Tissue Infections Modeled on the Subset of Diabetic Foot Infection

Hand washing practices and the occurrence of enteropathogenic bacteria among residents of a Nigerian University

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