Epidemiology and mortality outcome of carbapenem- and colistin-resistant Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa bloodstream infections

Balkhair, Abdullah; Saadi, K Al; Adawi, Badriya Al

doi:10.1016/j.ijregi.2023.01.002

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…One the other hand, this study carbapenem-resistant strains prevalence (57.6%, n=91/158) was higher than those (30.9, 37 and 27.7%) observed respectively by Haji et al (2021), Armin et al (2023) and Balkhair et al (2023). Indeed, any strain exhibiting reduced sensitivity to at least one of carbapenems and/or aztreonam was categorized resistant and therefore was suspicious of carbapenemase production.…”

Section: Discussioncontrasting

confidence: 46%

“…The results are in agreement with the study in Burkina Faso by Kabore et al (2022) who reported that GNB is mainly more resistant to antibiotics including carbapenems were E. coli and K. pneumoniae, but at higher rate (82.69%) and lower rate (9.62%) respectively. In contrast, Balkhair et al (2023) found a lowest resistance rate to carbapenems for E. coli (2.9%) and a higher carbapenem level resistance at 46.4 and 29.9% respectively for K. pneumoniae and P. aeruginosa.…”

Section: Discussionmentioning

confidence: 72%

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Multi-resistance to carbapenems by the production of Imipenemase (IMP)-types carbapenemases in Gram-negative bacilli in Burkina Faso

Damis,

Amana,

Rahimatou

et al. 2024

Afr. J. Biotechnol.

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The growing prevalence of Imipenemase (IMP) metallo-beta-lactamases (MBL) producing strains of Gram-negative bacilli (GNB) pathogens is a real concern for clinicians in the light of therapeutic impasses driven. However, resistance genes encoding these enzymes are hardly documented in Burkina Faso. This study aims to show carbapenem-resistance mediated by the production of IMP-type carbapenemase in GNB clinical strains collected in Ouagadougou, Burkina Faso. Strains resistance profile to imipenem, meropenem, ertapenem, doripenem and aztreonam was determined by the disk diffusion method. Classical polymerase chain reaction (PCR) was carried out to detect β-lactamase (bla) gene of IMP in resistant strains. Out of 158 GNB collected, 91 (57.6%) were resistant to at least one of the carbapenems and/or to aztreonam. The highest prevalence of resistant strains was observed in Escherichia coli (45.1%; n=41) and Klebsiella pneumoniae (26.5% n=24). Among 32 resistant strains blaIMP gene positive (35.2%), Escherichia coli was the predominant species carrying resistance gene (18.7%, n=17/91). The findings strengthen the scarce existing scientific data on antimicrobial resistance mediated by metallo-beta-lactamases (MBL) in Burkina Faso.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 72%

Multi-resistance to carbapenems by the production of Imipenemase (IMP)-types carbapenemases in Gram-negative bacilli in Burkina Faso

Damis,

Amana,

Rahimatou

et al. 2024

Afr. J. Biotechnol.

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“… 16 , 21 , 22 Additionally, 76.9% (40/52) of PR K. pneumoniae isolates were carbapenem resistant. The resistance rates of carbapenem-resistant K. pneumoniae to colistin in Taiwan 21 and Oman 23 were 17% and 24.2%, respectively. We found that polymyxin B exposure is a risk factor for hospitalized patients with PR Enterobacterales , which is consistent with the results of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Outcomes for Isolation with Polymyxin B-Resistant Enterobacterales from 2018–2022: A Case-Control Study

Yan,

Wu,

Wang

et al. 2023

IDR

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To analyze the risk factors and clinical outcomes of patients isolated with polymyxin B-resistant (PR) Enterobacterales from various clinical specimens to prevent and control the spread of these strains. Methods: This retrospective case-control study included 72 PR Enterobacterales-positive cases and 144 polymyxin B-susceptible (PS) Enterobacterales controls from 2018 to 2022. Patients with PR Enterobacterales isolated in various clinical cultures were defined as cases. Patients with PS Enterobacterales cultures at similar anatomic sites during the same period were randomly selected as controls. Data were collected from clinical and laboratory test records. Bivariable logistic regression and Pearson's chi-square tests were used to assess risk factors. Results: PR strains were predominantly Klebsiella pneumoniae (72.2%) and Salmonella enteritidis (8.3%). Of the patients, 66.04% were admitted to an intensive care unit (ICU). Risk factors for isolation with PR strains included chronic heart disease (P = 0.012; odds ratio [OR] 1.15; 95% confidence interval [CI] 1.03-1.28), immunosuppressant use (P = 0.016; OR 1.04 [1.0-1.07), drainage tube [head] (P = 0.006; OR 1.1 [1.0-1.1]), and polymyxin B exposure (P = 0.007; OR 1. 03 [1.0-1.06]. With respect to outcomes, admission to an ICU (P = 0.003; OR 7.1 [1.9-25.4]), hypertension (P = 0.035; OR 1.4 [1.02-1.83]), and drainage tube [head] (P = 0.044; OR 1.1 [1.0-1.15]) were associated with treatment failure. Additionally, treatment failure was more frequent in patients (45.83%) than in controls (14.58%). Conclusion:The major risk factors for isolation with PR strains were chronic heart disease, exposure to immunosuppressants, use of drainage tubes, and polymyxin B exposure. The isolation of PR strains in patients was a predictor of unfavorable outcomes. These findings provide a basis for monitoring the spread of PR Enterobacterales.

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“…(58.51 %) [ 24 ]infections are often associated with high mortality and morbidity in Asia. In India, a retrospective study conducted on bloodstream infections showed that 29.9 % (32/107) of the P. aeruginosa population was MDR, with 68.8 % (22/32) of mortality, whereas MDR A. baumannii resistant to carbapenem was 80.4 % (37/46), with a mortality rate of 67.6 % (25/37) [ 25 ]. Candida spp.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of MMV Pandemic Response Box compounds to identify potent compounds against clinically relevant bacterial and fungal clinical isolates in vitro

Sivasankar,

Boppe,

Grobusch

et al. 2024

New Microbes and New Infections

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Epidemiology and mortality outcome of carbapenem- and colistin-resistant Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa bloodstream infections

Cited by 11 publications

References 21 publications

Multi-resistance to carbapenems by the production of Imipenemase (IMP)-types carbapenemases in Gram-negative bacilli in Burkina Faso

Multi-resistance to carbapenems by the production of Imipenemase (IMP)-types carbapenemases in Gram-negative bacilli in Burkina Faso

Risk Factors and Outcomes for Isolation with Polymyxin B-Resistant Enterobacterales from 2018–2022: A Case-Control Study

Evaluation of MMV Pandemic Response Box compounds to identify potent compounds against clinically relevant bacterial and fungal clinical isolates in vitro

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