Epidemiology and outcome of influenza‐associated infections among hospitalized patients with acute respiratory infections, Egypt national surveillance system, 2016‐2019

Fahim, Manal; AbdElGawad, Basma; Hassan, H.; Naguib, Amel; Ahmed, El Sabbah; Afifi, Salma; Elsood, Hanaa Abu; Mohsen, Amira

doi:10.1111/irv.12867

Cited by 10 publications

(17 citation statements)

References 16 publications

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“…Despite the significantly lower fatality rate from influenza than SARS-CoV-2 found in this study, it is still higher than the rate reported during the inter-pandemic period [ 26 ]. Furthermore, high rates of ICU admissions and mechanical ventilation due to influenza were reported in this study.…”

Section: Discussioncontrasting

confidence: 68%

“…This pattern is different to that reported by Fahim et al in Egypt during the pre-pandemic phase, with higher fatality rates and severe outcomes among older people and a predominance of A/H1 26 . Some studies suggest that the A/H3 virus has declined in its ability to efficiently infect susceptible hosts but, according to this and other studies, influenza-associated hospitalisations and deaths are highest during seasons where A/H3 dominates [ 26 , 27 ]. Due to reduced influenza viruses circulating in 2020, the severity of the A/H3 subtype could have changed due to a prolonged absence of natural exposure to influenza viruses.…”

Section: Discussionmentioning

confidence: 94%

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Adapting an integrated acute respiratory infections sentinel surveillance to the COVID-19 pandemic requirements, Egypt, 2020–2022

Fahim

Elsood

AbdElGawad

et al. 2023

Public Health in Practice

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 94%

Adapting an integrated acute respiratory infections sentinel surveillance to the COVID-19 pandemic requirements, Egypt, 2020–2022

Fahim

Elsood

AbdElGawad

et al. 2023

Public Health in Practice

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“…[ 1 ] In Egypt, 17.3% of hospitalized patients with acute respiratory infections included one or more types of influenza viruses. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

Hesitancy for influenza vaccine among healthcare workers and mothers of preschool children: A cross-sectional study in Zagazig, Egypt

Hussein

Ibrahim

Badran

et al. 2022

Journal of Family and Community Medicine

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BACKGROUND: Vaccine hesitancy is a worldwide issue. To intensify our efforts to find a solution to this problem, we need to comprehend its magnitude and underlying causes. This study aimed to determine the prevalence of influenza vaccine hesitancy and the reasons for it among healthcare workers (HCWs) and mothers of preschool children attending Zagazig Maternal and Child Healthcare (MCH) Center, Sharqia Governorate. MATERIALS AND METHODS: A cross-sectional study was conducted in the Zagazig MCH Center involving 77 HCWs and 210 mothers of preschool children. Two validated questionnaires (one for HCWs and one for mothers of preschool children) were used to collect data on hesitancy to influenza vaccine. Data analysis perfomed using SPSS v 25.0. For quantitative variables, statistical significance was determined using t -test, whereas Chi-square test was employed for quantitative variables. Poisson regression model was used to determine the independent predictors of influenza vaccine hesitancy. P < 0.05 was used as a level of statistical significance. RESULTS: The prevalence of hesitancy to the influenza vaccine was 46.8% among HCWs and 54.3% among mothers of preschool children. Fear of side effects (42.9%) and doubt in the usefulness of the vaccine (42.1%) were the most frequent barriers. Hesitancy was significantly more prevalent in the negative-attitude HCWs (62.0%) than positive-attitude HCWs (18.5%). According to Poisson regression analysis, the age of the index child, the mothers' source of information, and the frequency of vaccination were the critical indicators of influenza vaccine hesitancy in the studied mothers. CONCLUSION: Influenza vaccine hesitancy among the studied sample is high (46.8% among HCWs, and 54.3% among mothers of preschool children). Periodic health education campaigns to increase awareness and change the negative attitude about the influenza vaccine are recommended.

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“…This study indicated that the largest proportion of patients with SARS-CoV-2/Flu co-infection occurs in the middle age group; in addition, most of the patients had experienced mild symptoms and were treated at home. This could reflect characteristics of influenza viral infection that affects mainly young ages and does not usually require hospitalization [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Other studies conducted in different countries reported an increase or decrease in fatality rates compared to SARS-CoV-2 infection [ 2 , 21 – 23 ]. This study reported higher rates of fatality among hospitalized patients with coinfection compared to rates of fatality from SARS-CoV-2 and influenza infections in Egypt [ 17 ]. The severity of the disease course and high fatality rates reported in this study could be related to the small number of hospitalized patients with coinfection, the high prevalence of comorbidities among them, or delay in influenza testing which could lead to delay in the effective case management.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, Disease Severity and Outcome of Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Viruses Coinfection Seen at Egypt Integrated Acute Respiratory Infections Surveillance, 2020–2022

Fahim

Roshdy

Deghedy

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Cocirculation of influenza (Flu) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (SARS-CoV-2/Flu) represent a public health concern as it may worsen the severity and increase fatality from coronavirus disease 2019. An increase in the number of patients with coinfection was recently reported. We studied epidemiology, severity, and outcome of patients with SARS-CoV-2/Flu coinfection seen at Egypt’s integrated acute respiratory infections surveillance to better describe disease impact and guide effective preventive measures. Methods. The first two outpatients were seen daily, and every fifth patient admitted to 19 sentinel hospitals with respiratory symptoms was enrolled. Patients were interviewed using a standardized questionnaire and provided nasopharyngeal swabs to be tested for SARS-CoV-2 and influenza by real-time polymerase chain reaction at the central laboratory. Data from all patients with coinfection were obtained, and descriptive data analysis was performed for patients’ demographics, clinical course, and outcome. Results. The total number of patients enrolled between January 2020 and April 2022 was 18,160 and 6,453 (35.5%) tested positive for viruses, including 52 (0.8%) coinfection. Of them, 36 (69.2%) were coinfected with Flu A/H3, 9 (17.3%) Flu-B, and 7 (13.5%) Flu A/H1. Patients’ mean age was 33.2 ± 21, 55.8% were males, and 20 (38.5%) were hospitalized, with mean hospital days 6.7 ± 6. At the hospital, 14 (70.0%) developed pneumonia, 6 (30.0%) ICU admitted, and 4 (20.0%) died. The hospitalization rate among patients coinfected with Flu-B and Flu A/H3 was 55.6 and 41.7%, with mean hospital days (8.0 ± 6 and 6.4 ± 6), pneumonia infection (40.0 and 80.0%), ICU admission (40.0 and 26.7%), and death (20.0% for both), while no patients hospitalized with A/H1. Conclusions. The recent increase in the number of SARS-CoV-2/Flu coinfections was identified in Egypt. The disease could have a severe course and high fatality, especially in those coinfected with Flu-B and Flu A/H3. Monitoring disease severity and impact is required to guide preventive strategy.

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Epidemiology and outcome of influenza‐associated infections among hospitalized patients with acute respiratory infections, Egypt national surveillance system, 2016‐2019

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 10 publications

References 16 publications

Adapting an integrated acute respiratory infections sentinel surveillance to the COVID-19 pandemic requirements, Egypt, 2020–2022

Adapting an integrated acute respiratory infections sentinel surveillance to the COVID-19 pandemic requirements, Egypt, 2020–2022

Hesitancy for influenza vaccine among healthcare workers and mothers of preschool children: A cross-sectional study in Zagazig, Egypt

Epidemiology, Disease Severity and Outcome of Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Viruses Coinfection Seen at Egypt Integrated Acute Respiratory Infections Surveillance, 2020–2022

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