Epidemiology and Outcome of Trichosporon Fungemia: A Review of 185 Reported Cases From 1975 to 2014

Liao, Yong; Lu, Xinliang; Yang, Suteng; Luo, Yi; Chen, Qi; Yang, Ruifu

doi:10.1093/ofid/ofv141

Cited by 85 publications

(71 citation statements)

References 63 publications

(111 reference statements)

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“…Due to the limited, small case series often involving single institutions, no comprehensive analysis is available to guide our understanding of the epidemiology, optimal therapeutic approaches and prognostic factors associated with trichosporonosis 23. Only molecular methods, such as IGS region sequencing, allow the complete identification of Trichosporon isolates at the species level.…”

Section: Discussionmentioning

confidence: 99%

Trichosporon asahiiseptic thrombophlebitis following lower extremity amputation in an immunocompetent host

Mada

Ayoade

et al. 2018

BMJ Case Reports

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A 59-year-old man with a history of peripheral vascular disease status post femoral popliteal bypass presented with critical limb ischaemia of the left leg. An arterial Doppler ultrasound showed an occluded graft requiring an above knee amputation. Five days after surgery, the patient developed fever, leucocytosis, significant stump swelling and pain, and serosanguinous discharge from his wound. Wound swab cultures from the stump grew A venous Doppler ultrasound revealed extensive thrombosis of the left lower extremity. Biopsy of the left thigh muscle showed necrotic thrombus with fungal hyphae in the clotted blood vessel. The left femoral vein was subsequently resected, and the excised venous tissue also grew The patient was successfully treated with voriconazole based on antifungal susceptibilities. This case describes an invasive fungal infection in the absence of typical immunosuppressive conditions commonly associated with spp. It also illustrates the role of a combination of antimicrobial and surgical management in achieving cure.

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Section: Discussionmentioning

confidence: 99%

Trichosporon asahiiseptic thrombophlebitis following lower extremity amputation in an immunocompetent host

Mada

Ayoade

et al. 2018

BMJ Case Reports

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“…The incidence of invasive trichosporonosis has been increased over the past 4 decades with the increased immunocompromised population, mainly those with hematological malignant diseases, AIDS patients and organ transplant recipients [2]. Additional risk factors include the use of corticosteroid, chemotherapy, as well as the use of medical implanted devices [2].…”

Section: Introductionmentioning

confidence: 99%

“…Additional risk factors include the use of corticosteroid, chemotherapy, as well as the use of medical implanted devices [2]. …”

Section: Introductionmentioning

confidence: 99%

In Vitro Antifungal Activity of Sertraline and Synergistic Effects in Combination with Antifungal Drugs against Planktonic Forms and Biofilms of Clinical Trichosporon asahii Isolates

2016

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Trichosporon asahii (T. asahii) is the major pathogen of invasive trichosporonosis which occurred mostly in immunocompromised patients. The biofilms formation ability of T. asahii may account for resistance to antifungal drugs and results a high mortality rate. Sertraline, a commonly prescribed antidepressant, has been demonstrated to show in vitro and in vivo antifungal activities against many kinds of pathogenic fungi, especially Cryptococcus species. In the present study, the in vitro activities of sertraline alone or combined with fluconazole, voriconazole, itraconazole, caspofungin and amphotericin B against planktonic forms and biofilms of 21 clinical T. asahii isolates were evaluated using broth microdilution checkerboard method and XTT reduction assay, respectively. The fractional inhibitory concentration index (FICI) was used to interpret drug interactions. Sertraline alone exhibited antifungal activities against both T. asahii planktonic cells (MICs, 4–8 μg/ml) and T. asahii biofilms (SMICs, 16–32 μg/ml). Furthermore, SRT exhibited synergistic effects against T. asahii planktonic cells in combination with amphotericin B, caspofungin or fluconazole (FICI≤0.5) and exhibited synergistic effects against T. asahii biofilms in combination with amphotericin B (FICI≤0.5). SRT exhibited mostly indifferent interactions against T. asahii biofilms in combination with three azoles in this study. Sertraline-amphotericin B combination showed the highest percentage of synergistic effects against both T. asahii planktonic cells (90.5%) and T. asahii biofilms (81.0%). No antagonistic interaction was observed. Our study suggests the therapeutic potential of sertraline against invasive T. asahii infection, especially catheter-related T. asahii infection. Further in vivo studies are needed to validate our findings.

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“…Trichosporonosis is a life-threatening mycosis, particularly for patients with hematological malignancies with a poor prognosis. [7][8][9] T. asahii is also known as an antigen for summer-type hypersensitivity pneumonitis (SHP). In Japan, SHP is considered a type III or IV allergy that occurs mainly in summer from April to November.…”

mentioning

confidence: 99%

Growth Inhibition of an Opportunistic Yeast Pathogen <i>Trichosporon asahii</i> by <i>Staphylococcus epidermidis</i>

Ikeda

Ogasawara

Takatori

et al. 2017

Biological & Pharmaceutical Bulletin

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In the co-culture of Staphylococcus epidermidis and Trichosporon asahii, a fungal pathogen, it was observed that live S. epidermidis inhibited the growth of T. asahii. Soluble active anti-T. asahii substances were speculated to be produced by S. epidermidis in culture medium. Using 1 H-and 13 C-NMR spectra and electron ionization-high resolution mass spectrometry (HR-negative-FAB-MS), we separated the active molecule and identified it as lactic acid. Commercially available L-lactic acid and D-lactic acid inhibited the growth of T. asahii. These results show that metabolites from bacterial populations are involved in the interactions of pathogenic fungi. The use of antibacterial agents to treat primary diseases could lead to the disruption of normal microbial communities and could cause opportunistic infections such as trichosporonosis.

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Epidemiology and Outcome of Trichosporon Fungemia: A Review of 185 Reported Cases From 1975 to 2014

Abstract: We first reviewed the English-language literature for reported cases of Trichosporon fungemia over the past four decades, and did comprehensive analysis in order to guide our understanding of epidemiology and outcome-related aspects, especially the antifungal treatment and CVC management.

Cited by 85 publications

References 63 publications

Trichosporon asahiiseptic thrombophlebitis following lower extremity amputation in an immunocompetent host

Trichosporon asahiiseptic thrombophlebitis following lower extremity amputation in an immunocompetent host

In Vitro Antifungal Activity of Sertraline and Synergistic Effects in Combination with Antifungal Drugs against Planktonic Forms and Biofilms of Clinical Trichosporon asahii Isolates

Growth Inhibition of an Opportunistic Yeast Pathogen <i>Trichosporon asahii</i> by <i>Staphylococcus epidermidis</i>

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