Epidemiology and Outcomes of Glomerular Diseases in Low- and Middle-Income Countries

Ekrikpo, Udeme; Obiagwu, Patience Ngozi; Chika-Onu, Ugochi; Yadla, Manjusha; Karam, Sabine; Tannor, Elliot Koranteng; Bello, Aminu K.; Okpechi, Ikechi G.

doi:10.1016/j.semnephrol.2023.151316

Cited by 5 publications

(4 citation statements)

References 142 publications

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“…The increase in DN in our series compared to the previous era may be due to increasing diabetes prevalence and more standardized indications for biopsies similar to other global regions 6 , 15 . Since kidney biopsies were performed only in patients with unusual features such as massive proteinuria or rapid disease progression, high kidney failure and mortality rates in DN may reflect the advanced stage of kidney disease and concomitant cardiovascular risk factors already present at the time of biopsy 21 .…”

Section: Discussionmentioning

confidence: 63%

“…The frequency of different GD varies worldwide due to differences in genetic, environmental factors, and biopsy selection practices 6 . In our series, LN was the commonest GD, followed by IgAN, FSGS, MN, and MCD.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies from lower to middle-income countries have examined the prevalence of various types of GD in cross-sectional research or individual GD types over time 6 . However, there are few recent studies covering the period since the year AD 2000 that use biopsy registry data to compare outcomes in patients with both primary and secondary GD.…”

Section: Discussionmentioning

confidence: 99%

“…The distribution of GD types differs worldwide 5 . GD may contribute to even higher proportions of ESKD in low and middle-income countries, especially in patients under age 60 2 , 6 . Southeast Asia covers 8.5% of the world's population, with one of the largest burdens of CKD globally 7 .…”

Section: Introductionmentioning

confidence: 99%

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Years of life lost and long-term outcomes due to glomerular disease in a Southeast Asian Cohort

Janphram,

Worawichawong,

Assanatham

et al. 2023

Sci Rep

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Death and end-stage kidney disease (ESKD) are major outcomes of glomerular disease. (GD) The years of potential life lost (YLL) may provide additional insight into the disease burden beyond death rates. There is limited data on premature mortality in GD. In this retrospective observational cohort study, we evaluated the mortality, ESKD rates, and YLL in Thais with biopsy-proven GD. The mortality and combined outcome rates were determined by log-rank test and ESKD by using a competing risk model. YLL and premature life lost before age 60 were calculated for different GD based on the life expectancy of the Thai population. Patients with GD (n = 949) were followed for 5237 patient years. The death rate and ESKD rates (95%CI) were 4.2 (3.7–4.9) and 3.3 (2.9–3.9) per 100 patient-years, respectively. Paraprotein-related kidney disease had the highest death rate, and diabetic nephropathy had the highest ESKD rate. Despite not having the highest death rate, lupus nephritis (LN) had the highest YLL (41% of all GD) and premature loss of life before age 60. In conclusion, YLL provided a different disease burden assessment compared to mortality rates and identified LN as the major cause of premature death due to GD in a Southeast Asian cohort.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%