Epidemiology and outcomes of hospitalization of influenza in the cancer population in Taiwan

Tai, Yu; Lee, Ta-Chung; Chang, Hsiao-Ling; Chen, Kow-Tong

doi:10.1007/s00432-009-0545-0

Cited by 13 publications

(13 citation statements)

References 18 publications

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“…Like in all children, influenza infection among children with malignancies leads to increased numbers of missed school days for children, missed working days for caregivers who must care for their children, and excess healthcare costs (13,14). Previous research has documented the presence of seasonal influenza outbreaks among patients with malignancies and suggests that cancer patients are at high risk for acquiring influenza infections in health care settings (10,(15)(16)(17). In this study, we evaluated the incidence of influenza infection among childhood cancer survivors.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Influenza Among Childhood Cancer Survivors in South Korea: A Population-based Retrospective Analysis

Heo

Jung

Noh

et al. 2020

In Vivo

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Background/Aim: We quantified the incidence, and identified risk factors for influenza infection among childhood cancer survivors in South Korea, an at-risk population. Patients and Methods: Nationwide health insurance claims data were used to assess the frequency of influenza among childhood cancer survivors (aged <20 years) diagnosed between January 2009 and April 2016. A multivariable logistic regression was constructed to identify risk factors for influenza. Results: Of 6,457 children cancer survivors, 1,704 (27.0%) were diagnosed with influenza. Influenza was common in children <5 years old and infections were highest between late October and April. Over 60% of influenza treatment claims came from private clinics. Risk factors for influenza included age <9 years. Conclusion: Childhood cancer survivors are particularly atrisk for influenza infection during the traditional influenza season. Identifying risks for influenza infection will help to establish countermeasures for reducing the influenza infections in at-risk cancer surviving children. With ongoing advances in science and medicine, the survival rates for childhood cancer has continued to improve. For example, in Korea, the five-year survival rate of childhood cancer has improved from 56.1% in 1993-1995 to 80.3% in 2007-2011 (1). Given this remarkable increase in the number of long-term childhood cancer survivors, there is increasing interest in identifying and remediating various complications suffered by long-term survivors (2). Of note, childhood cancer survivors experience an increased risk for morbidity and mortality resulting from infections and infection-related complications (1, 3, 4). According to a study of the Childhood Cancer Survivor Study cohort, childhood cancer survivors are at an increased risk of infection-related mortalities compared to the US population as a whole. As well, survivors have a higher incidence of all-cause infection as well as higher rates of infection-related complications compared to their siblings (2, 5). Paediatric cancer patients may experience delayed infection-related complications because of their underlying disease, or, as a result of receiving cancer fighting chemotherapy, which may cause immune dysfunction. Previous studies have shown that major immunity in most patients will generally recover up to 6-12 months after chemotherapy. However, profound deficiencies in lymphocyte function may make the patient vulnerable to infection (2, 6-8). Influenza is a form of acute respiratory infections, which, across all age groups, affects 10-20% of the population each year. Most healthy people who are infected with influenza will improve on their own without any progressive sequelae. However, high-risk groups, including infants, older adults, and those with chronic diseases, are at an elevated risk for exacerbating their existing disease, or for developing additional complications. All patients with hematologic or solid cancers treated with chemotherapy are considered to be high risk for manifesting influenza-related co...

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Section: Discussionmentioning

confidence: 99%

Incidence of Influenza Among Childhood Cancer Survivors in South Korea: A Population-based Retrospective Analysis

Heo

Jung

Noh

et al. 2020

In Vivo

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“…The cost of hospitalization included the daily room charge, inpatient physician visits, medications, intravenous fluids, laboratory tests, and one post‐discharge outpatient visit. The cost of an outpatient visit, including laboratory tests and medications, was derived from the data of the NHIR, Taiwan [19] and was consistent with current published costs [12]. From this report, we also obtained the cost of a regular emergency department visit, the cost of treatment for a dying adult, including ambulance transportation and 30 min of critical care in an emergency department, and the cost of influenza vaccine administration [19].…”

Section: Methodsmentioning

confidence: 99%

Cost-effectiveness of influenza immunization in adult cancer patients in Taiwan

Lin

Hsu

et al. 2010

Clinical Microbiology and Infection

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The aim of this study was to investigate the efficacy of the influenza vaccine among cancer patients in Taiwan. We determined the effect of immunization on the following outcomes of disease: hospitalizations, emergency department visits, hospital outpatient visits, physician office visits, and deaths. Cost-effectiveness was analysed from the perspectives of the healthcare system and society. A decision tree was used, with estimates of disease burden and costs based on data from published and unpublished sources. The model followed 34 112 cancer patients aged 20-64 years who were registered by the Taiwan National Cancer Registry in 2002. An influenza immunization programme for the cancer population would prevent 2555 cases of all types of influenza infection, 660 of which would be serious cases involving hospitalization, emergency department visits and death. From the perspective of the healthcare system, the programme would cost US$7.7 million, providing net savings of US$5.4 million. From a societal perspective, the programme would cost US$28.6 million, providing net savings of US$22.3 million. This corresponds to savings of US$2107 and US$6338 per case averted, from healthcare and societal perspectives, respectively, as well as 110 lives saved. Lesser disease burden, greater vaccine efficacy and lower cost of hospitalizations increased cost-effectiveness. Influenza immunization for cancer patients is cost-saving and cost-effective from a healthcare and societal perspective in Taiwan. We highly recommend annual influenza vaccinations for this patient group.

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“…7 The impact of seasonal influenza on patients with impaired immune defenses, such as those with cancer or recipients of hematopoietic stem cell transplantation (HSCT), seasonal influenza has been reported. Complications include higher rates of infection 8 and persistent shedding, 9 progression to lower airway disease, 10 need for mechanical ventilation 11 and mortality. 12e14 However, the consequences of 2009 H1N1 Influenza virus infection in patients who are immunocompromised from cancer or its treatment are not known.…”

Section: Introductionmentioning

confidence: 99%

2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients

Redelman-Sidi

Sepkowitz

Huang

et al. 2010

Journal of Infection

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Epidemiology and outcomes of hospitalization of influenza in the cancer population in Taiwan

Cited by 13 publications

References 18 publications

Incidence of Influenza Among Childhood Cancer Survivors in South Korea: A Population-based Retrospective Analysis

Incidence of Influenza Among Childhood Cancer Survivors in South Korea: A Population-based Retrospective Analysis

Cost-effectiveness of influenza immunization in adult cancer patients in Taiwan

2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients

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