Epidemiology and Outcomes of Symptomatic Cholelithiasis and Cholecystitis in the USA: Trends and Urban–Rural Variations

Li, Suqing; Guizzetti, Leonardo; Ma, Christopher; Shaheen, Abdel Aziz; Dixon, Elijah; Ball, Chad G.; Wani, Sachin; Forbes, Nauzer

doi:10.1007/s11605-023-05604-0

Cited by 11 publications

(3 citation statements)

References 37 publications

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“…In particular, the biggest number of cholecystectomies per 10,000 population in 2019 was performed in Ternopil (17.9), Ivano-Frankivsk (15.3) and Chernihiv (15.1) regions, while the lowest numbers were in Kharkiv (5.5), Donetsk (5.56) and Chernivtsi (5.7) regions. Also, the number of patients hospitalized for cholelithiasis, and the rate of cholecystectomies has geographical disproportions and downtrends in the United States of America (USA) (Li et al. , 2023).…”

Section: Resultsmentioning

confidence: 99%

Management of gallstone disease and chronic liver diseases during the COVID-19 outbreak in Ukraine: an ecological study

Bogomaz,

Natrus,

Ziuz

et al. 2023

IJHG

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PurposeThe purpose of this paper is to estimate the possible impact of the COVID-19 pandemic on the hospitalization and hospital mortality of the patients with gallstone disease and chronic liver diseases (CLD) in the worst pandemic period in Ukraine.Design/methodology/approachA retrospective comparative analysis of annual reports data of all economy subjects, which conducted economic activity in medical practice for 2019 and 2021. Data was accepted from the Ministry of Health of Ukraine, the National Security and Defense Council of Ukraine (NSDC) and the State Statistics Service of Ukraine (SSSU).FindingsThe total hospitalization rates for diffuse liver disease and cholelithiasis significantly decreased during the peak of the COVID-19 pandemic in Ukraine, compared to the values of 2019. At the same time, the rates of in-hospital mortality for these diseases have significantly grown. Also, various proportions of similar trends were described in other countries during the first wave of the pandemic.Originality/valueThis paper highlights the fact that regulatory restrictions and the fear of the population of referring to healthcare facilities considering the high risk of getting an infection had significant disruption to medical care for patients with gallstone disease and CLD. Improving the management of medical resources and strengthening all kinds of institutions in the healthcare system must be thought about if similar challenges appear in the future.

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Section: Resultsmentioning

confidence: 99%

Management of gallstone disease and chronic liver diseases during the COVID-19 outbreak in Ukraine: an ecological study

Bogomaz,

Natrus,

Ziuz

et al. 2023

IJHG

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“…A colelitíase ocorre parte significativa da população mundial e a sua incidência apresentou tendência de crescimento neste século (Li et al, 2023). Conforme dados analisados, a região nordeste exibiu aumento dos óbitos por colecistite próximos a 45% (Gráfico 1).…”

Section: Discussionunclassified

Tendência da mortalidade por colecistite no Nordeste brasileiro, de 2013 a 2022

Sousa,

Araújo,

Rosa

2024

RSD

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A colelitíase comumente permanece assintomática, porém pode ocorrer a obstrução do ducto cístico, gerando sintomas. O objetivo do estudo foi conhecer o perfil epidemiológico dos indivíduos que evoluíram ao óbito por colecistite na região Nordeste, de 2013 a 2022, e compreender os aspectos associados a essa mortalidade. Trata-se de uma pesquisa de cunho epidemiológico, observacional, descritivo, de abordagem quantitativa, que utilizou dados do Departamento de Informações do Sistema Único de Saúde (DATASUS) através do Sistema de Informações sobre Mortalidade (SIM). As variáveis investigadas foram número de óbitos, taxa de mortalidade, sexo, faixa etária, cor/raça, estado civil e escolaridade. A pesquisa constatou um total de 3847 óbitos devido à colecistite na região Nordeste e tendência crescente no período estudado. O estado da Bahia apresentou o maior percentual (20,9%) e os estados com os menores Índices de Desenvolvimento Humano (IDH) exibiram menores taxas de mortalidade. O sexo feminino prevaleceu com 61,3% e a houve predomínio de mortes em faixas etárias elevadas (62,8% para 70 a 79 anos e 80 anos ou mais). Pardos e brancos constituíram 86,23% dos óbitos e os estados civis referentes à casados e viúvos também exibiram os maiores valores (61,27%). Os dados analisados contribuem para a intervenção em saúde, uma vez que o acesso a subsídios informacionais, que determinam os padrões de uma doença em sociedade, permite a criação de políticas públicas direcionadas e efetivas.

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“…Cholelithiasis, also known as gallstone disease, is a common hepatobiliary disorder. The formation of gallstone is the major risk factor for developing cholecystitis [ 1 ]. Cholelithiasis can be primarily subdivided into cholesterol gallstone and pigment gallstones, among which, the cholesterol gallstone is much more commonly seen.…”

Section: Introductionmentioning

confidence: 99%

Plasma campesterol and ABCG5/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses

Mi,

Jiang,

et al. 2024

Hum Genomics

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The causal relationships between plasma metabolites and cholelithiasis/cholecystitis risks remain elusive. Using two-sample Mendelian randomization, we found that genetic proxied plasma campesterol level showed negative correlation with the risk of both cholelithiasis and cholecystitis. Furthermore, the increased risk of cholelithiasis is correlating with the increased level of plasma campesterol. Lastly, genetic colocalization study showed that the leading SNP, rs4299376, which residing at the ABCG5/ABCG8 gene loci, was shared by plasma campesterol level and cholelithiasis, indicating that the aberrant transportation of plant sterol/cholesterol from the blood stream to the bile duct/gut lumen might be the key in preventing cholesterol gallstone formation.

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Epidemiology and Outcomes of Symptomatic Cholelithiasis and Cholecystitis in the USA: Trends and Urban–Rural Variations

Cited by 11 publications

References 37 publications

Management of gallstone disease and chronic liver diseases during the COVID-19 outbreak in Ukraine: an ecological study

Management of gallstone disease and chronic liver diseases during the COVID-19 outbreak in Ukraine: an ecological study

Tendência da mortalidade por colecistite no Nordeste brasileiro, de 2013 a 2022

Plasma campesterol and ABCG5/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses

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