Epidemiology and Pathology of Autonomous Parvoviruses

Truyen, Uwe; Parrish, Colin R.

doi:10.1159/000060331

Cited by 7 publications

(6 citation statements)

References 48 publications

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“…0.0002–0.0027%). However, the abundance of parvoviruses in winter and spring/summer samples (0.05–0.94% of reads in samples from late winter, 0.02–0.03% of reads in spring/summer) were low, except for the juvenile Pacific black duck December 2016 sample (4.77% of reads), which may be due to the age of the birds rather than any seasonal factor, as parvoviruses prefer multiplying host cells for their replication 27 (Table 1 ). Picornaviruses, in contrast, were mainly found during late autumn to late winter months with 1–3 picornaviruses with an abundance of 0.0260–15.8490% [Table 1 ].…”

Section: Resultsmentioning

confidence: 93%

“…However, in the case of animal parvoviruses, very few studies have been conducted to determine their seasonal prevalence, especially from Australia 43 , 44 . The abundance of parvovirus was high in the juvenile Pacific black duck samples compared to their adult counterparts, which suggests that these duck chaphamaparvoviruses prefer juvenile hosts like any other parvovirus 27 . Duck picornaviruses were mainly found during late autumn to late winter months.…”

Section: Discussionmentioning

confidence: 92%

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Metagenomic characterisation of avian parvoviruses and picornaviruses from Australian wild ducks

Vibin,

Chamings,

Klaassen

et al. 2020

Sci Rep

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Ducks can shed and disseminate viruses and thus play a role in cross-species transmission. In the current study, we detected and characterised various avian parvoviruses and picornaviruses from wild Pacific black ducks, Chestnut teals, Grey teals and Wood ducks sampled at multiple time points from a single location using metagenomics. We characterised 46 different avian parvoviruses belonging to three different genera Dependoparvovirus, Aveparvovirus and Chaphamaparvovirus, and 11 different avian picornaviruses tentatively belonging to four different genera Sicinivirus , Anativirus , Megrivirus and Aalivirus . Most of these viruses were genetically different from other currently known viruses from the NCBI dataset. The study showed that the abundance and number of avian picornaviruses and parvoviruses varied considerably throughout the year, with the high number of virus reads in some of the duck samples highly suggestive of an active infection at the time of sampling. The detection and characterisation of several parvoviruses and picornaviruses from the individual duck samples also suggests co-infection, which may lead to the emergence of novel viruses through possible recombination. Therefore, as new and emerging diseases evolve, it is relevant to explore and monitor potential animal reservoirs in their natural habitat.

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Section: Resultsmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 92%

Metagenomic characterisation of avian parvoviruses and picornaviruses from Australian wild ducks

Vibin,

Chamings,

Klaassen

et al. 2020

Sci Rep

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“…Lorsqu'un chat développe cette maladie, le virus se réplique, d'une part, dans les cellules intestinales au niveau des cryptes de la muqueuse, causant de [11,12]. De plus, lors d'infection foetale, ce virus peut être à l'origine d'aplasie cérébelleuse [13].…”

Section: Discussionunclassified

Panleucopénie féline aiguë : à propos d’un cas traité avec succès par l’interféron-ω

Siméon¹,

Mercier²,

Maziére³

et al. 2009

Pratique Médicale et Chirurgicale de l'Animal de Compagnie

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“…Viral persistence is a feature of infection caused by other autonomous parvoviruses (15,48,55,58). Among these, the most detailed pathogenesis studies have been performed with Aleutian disease virus (ADV) (2,9,10,39).…”

Section: Discussionmentioning

confidence: 99%

Persistent Rat Virus Infection in Smooth Muscle of Euthymic and Athymic Rats

Jacoby

Johnson

Paturzo

et al. 2000

J Virol

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Rat virus (RV) infection can cause disease or disrupt responses that rely on cell proliferation. Therefore, persistent infection has the potential to amplify RV interference with research. As a step toward determining underlying mechanisms of persistence, we compared acute and persistent RV infections in infant euthymic and athymic rats inoculated oronasally with the University of Massachusetts strain of RV. Rats were assessed by virus isolation, in situ hybridization, and serology. Selected tissues also were analyzed by Southern blotting or immunohistochemistry. Virus was widely disseminated during acute infection in rats of both phenotypes, whereas vascular smooth muscle cells (SMC) were the primary targets during persistent infection. The prevalence of virus-positive cells remained moderate to high in athymic rats through 8 weeks but decreased in euthymic rats by 2 weeks, coincident with seroconversion and perivascular infiltration of mononuclear cells. Virus-positive pneumocytes and renal tubular epithelial cells also were detected through 8 weeks, implying that kidney and lung excrete virus during persistent infection. Viral mRNA was detected in SMC of both phenotypes through 8 weeks, indicating that persistent infection includes virus replication. However, only half of the SMC containing viral mRNA at 4 weeks stained for proliferating cell nuclear antigen, a protein expressed in cycling cells. The results demonstrate that vasculotropism is a significant feature of persistent infection, that virus replication continues during persistent infection, and that host immunity reduces, but does not eliminate, infection.Rat virus (RV) is a common virus of laboratory rats and the prototype virus for the family Parvoviridae (29, 35). It is one of three parvovirus serotypes which infect rats; the others are H-1 virus (54) and rat parvovirus (4). RV can disrupt research by causing disease or distorting biological responses in laboratory rats (53). These effects have been attributed to the proclivity of autonomous parvoviruses for mitotically active cells (18). RV infection in fetal and infant rats, which have numerous cycling cells, can lead to severe tissue necrosis and clinical morbidity (30, 34). The preference of RV for mitotically active cells is also thought to account for its ability to distort responses dependent on cell proliferation, including suppression of tumor growth (7) and immune responses to transplantable neoplasms (13) and tissue alloantigens (40).The risks to biomedical research from RV are heightened by the persistence of infection after the onset of antiviral immunity. A capacity for persistence was suspected from a early study of RV which demonstrated infectious virus in immune rats (50). We subsequently found that some rats inoculated with RV by the oronasal route at 2 days of age harbored infection for at least 6 months and excreted virus for up to 11 weeks, well after the onset of antiviral immunity (32). Susceptibility to persistent infection appeared to be age dependent, since randomly bred ...

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Epidemiology and Pathology of Autonomous Parvoviruses

Cited by 7 publications

References 48 publications

Metagenomic characterisation of avian parvoviruses and picornaviruses from Australian wild ducks

Metagenomic characterisation of avian parvoviruses and picornaviruses from Australian wild ducks

Panleucopénie féline aiguë : à propos d’un cas traité avec succès par l’interféron-ω

Persistent Rat Virus Infection in Smooth Muscle of Euthymic and Athymic Rats

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