Epidemiology and pathology of oral squamous cell carcinoma in a multi-ethnic population: Retrospective study of 154 cases over 7 years in Qatar

Elaiwy, Orwa; Ansari, Walid El; Alkhalil, Moustafa; Ammar, Adham

doi:10.1016/j.amsu.2020.10.029

Cited by 29 publications

(24 citation statements)

References 38 publications

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“…It is usually found in an older age population, also male sex majority. Young population in reported studies defined for age group between 35-to-45year of age [3,4,7].…”

Section: Resultsmentioning

confidence: 99%

“…Tongue squamous cell carcinoma (TSCC) is the most common oral cancer (OC), approximately 45% of all OC are TSCC. It is the eighth most frequent cancer-related death worldwide and prevalence profound high in Central and Southeast Asian countries [1][2][3][4]. The incidence and mortality rates of OC vary globally and are higher in developing countries.…”

Section: Introductionmentioning

confidence: 99%

“…The incidence and mortality rates of OC vary globally and are higher in developing countries. Tobacco use and alcohol consumption traditionally are the primary risk factors for head and neck cancers [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Head and neck squamous cell carcinoma (SCC) primarily is a disease of adults age 45 and older [6]. However data from developed countries showed that 6% of all OC occurred in young people under the age of 45 years in both men and women, and the incidence of this population is steadily increasing [4,6,7]. It was also demonstrated that younger patients do not show the typical exposures of tobacco and alcohol drinking as they are a well-known risk factors for older adult patients [2,6].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Tongue Squamous Cell Carcinoma in Younger Adult Female with a History of Breast Cancer: A Rare Case Report

Yue¹,

Filbertine²

2021

Advances in Health Sciences Research

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Tongue squamous cell carcinoma (TSCC) is the most common presentation of oral cancer (OC). Risk factor traditionally associated with tobacco smoking and alcohol consumption affecting both sexes starting in four decades. Current case report highlights the associated risk factors from this patient and among younger age population. A 39 years old women with history of 3 years breast cancer (BC) had underwent surgery and chemotherapy, came to Ear, Nose, and Throat (ENT) clinic with pain while swallowing for 2 weeks. Examination shows redness on her right pharyngeal arch and right side of the tongue. During follow up, she presented with persisted swollen tongue. We suspected a tongue mass with inflammation of right palatine tonsil and a differential diagnosis of neoplasm was held. Apart from imaging modalities (endoscopy and head computed tomography scan), biopsy revealed a well differentiated squamous cell carcinoma without lymphovascular invasion, thus was referred to ENT subspecialist for further multidisciplinary treatment approach. To our knowledge, this is the first case of TSCC in patient with history of BC, in younger age population, and no family history. While the reported cases of TSCC in young adult are increasing, however previous studies demonstrated contradictive risk factors. Regardless the possibility of the case in younger adult population, the pathogenesis knowledge in TSCC is sparse. We proposed that our patient was most likely to develop oral SCC by chemotherapy-induced immunosuppression and carcinogenesis, as well as poor oral hygiene status of our patient.

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“…It is usually found in an older age population, also male sex majority. Young population in reported studies defined for age group between 35-to-45year of age [3,4,7].…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tongue Squamous Cell Carcinoma in Younger Adult Female with a History of Breast Cancer: A Rare Case Report

Yue¹,

Filbertine²

2021

Advances in Health Sciences Research

View full text Add to dashboard Cite

show abstract

“…Oral cancer, categorized under head and neck cancer, consists of cancers occurring in the oral cavity. Cancers originated from oral cavity, tongue, lip and mouth accumulatively represents the 8th most common cancer with more than 300,000 cases per annum ( D'Cruz et al, 2018 ; Elaiwy et al, 2020 ). There were roughly about 65,410 head and neck cancers cases recorded in the United States in 2019, which is accountable for 3.7% of new cancers ( Kim and Kim, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicle-Mediated Chemoresistance in Oral Squamous Cell Carcinoma

Law

Khoo

Lim

et al. 2021

Front. Mol. Biosci.

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Oral Squamous Cell Carcinoma (OSCC) remains a cancer with poor prognosis and high recurrence rate. Even with multimodal treatment options available for OSCC, tumor drug resistance is still a persistent problem, leading to increased tumor invasiveness among OSCC patients. An emerging trend of thought proposes that extracellular vesicles (EVs) play a role in facilitating tumor progression and chemoresistance via signaling between tumor cells. In particular, exosomes and microvesicles are heavily implicated in this process by various studies. Where primary studies into a particular EV-mediated chemoresistance mechanism in OSCC are limited, similar studies on other cancer cell types will be used in the discussion below to provide ideas for a new line of investigation into OSCC chemoresistance. By understanding how EVs are or may be involved in OSCC chemoresistance, novel targeted therapies such as EV inhibition may be an effective alternative to current treatment options in the near future. In this review, the current understandings on OSCC drug mechanisms under the novel context of exosomes and microvesicles were reviewed, including shuttling of miRNA content, drug efflux, alteration of vesicular pH, anti-apoptotic signaling, modulation of DNA damage repair, immunomodulation, epithelial-to-mesenchymal transition and maintenance of tumor by cancer stem cells.

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Epidemiology and incidence of oral squamous cell carcinoma in the Iraqi population over 5 years (2014–2018)

Alshami

Al‐Maliky

Alsagban

et al. 2023

Health Science Reports

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Background Oral squamous cell carcinoma is one of the most common and life‐threatening neoplasms worldwide, and is responsible for approximately 90% of all oral malignancies. Aim This study was aimed at providing updated information on oral squamous cell carcinoma in all Iraqi governorates for the 5‐year period from 2014 to 2018, including the annual incidence and demographic variables. Materials and Methods The total number of oral squamous cell carcinoma cases in Iraq, along with associated demographic information (age, sex, and site), for the 5‐year period from 2014 to 2018 was obtained. The statistical analysis consisted of descriptive analysis, including frequency, percentage, and mean ± standard deviation. A χ 2 test was performed to compare frequencies between male and female patients, among age groups, and among different OSCC sites. The χ 2 test was also used to assess the association of each OSCC site with age and sex. The significance threshold was set at p < 0.05, and the confidence interval was set at 95%. The incidence rate of oral squamous cell carcinoma for each year was calculated by dividing the number of OSCC cases per year by the population of Iraq, then multiplying the result by 100,000. Results A total of 722 cases were recorded. Statistically, oral squamous cell carcinoma was found to be more prevalent in males and individuals over 40 years of age. The tongue was the most common site of occurrence. Lip squamous cell carcinoma cases were high in males. The incidence rate of oral squamous cell carcinoma was estimated to be 0.4 per 100,000 people. Conclusion Males and older people are at relatively higher risk of developing oral cancer. The tongue is the most affected site, but any site in the oral cavity may be involved. Further exploration of the causes of oral malignancy in Iraq is necessary to improve prevention strategies.

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Epidemiology and pathology of oral squamous cell carcinoma in a multi-ethnic population: Retrospective study of 154 cases over 7 years in Qatar

Cited by 29 publications

References 38 publications

Tongue Squamous Cell Carcinoma in Younger Adult Female with a History of Breast Cancer: A Rare Case Report

Tongue Squamous Cell Carcinoma in Younger Adult Female with a History of Breast Cancer: A Rare Case Report

Extracellular Vesicle-Mediated Chemoresistance in Oral Squamous Cell Carcinoma

Epidemiology and incidence of oral squamous cell carcinoma in the Iraqi population over 5 years (2014–2018)

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