Epidemiology and pathophysiology of osteoporosis in men

Adler, Robert A.

doi:10.1007/s11914-996-0030-5

Cited by 18 publications

(13 citation statements)

References 55 publications

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“…These values are higher than those reported previously (Brzozowska et al, 2002) and might indicate a better prevention of osteoporosis among women in Switzerland. Still, although male gender and increased body mass index might be protective towards osteoporosis (Felson et al, 1993), the low prevalence of calcium supplements (with or without vitamin D) in men raises some concern, as it has been shown that dietary calcium intake among elderly is below the recommended levels (Gennari, 2001;Marshall et al, 2001;Sharkey et al, 2002;Dumartheray et al, 2006) and that mortality and morbidity after hip fracture are much greater in men (Adler, 2006). Supplemental iron is usually prescribed for anaemia, which is more frequent among premenopausal women (Hercberg et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and characteristics of vitamin or dietary supplement users in Lausanne, Switzerland: the CoLaus study

et al. 2007

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Background and objectives: Vitamin þ mineral supplement (VMS) and dietary supplement (DS) use is widespread in the general population, but the motivations for such use are poorly known. The prevalence and characteristics of VMS and DS users in Lausanne, Switzerland, were thus assessed. Method: Cross-sectional study was performed including 3249 women and 2937 men (CoLaus study). VMS were defined as single or multivitamin-multimineral preparations. DS included omega-3 or omega-6 fatty acids, herbal teas, plant or animal extracts and bacterial (Lactobacillus) preparations. Calcium and iron supplements were assessed separately. Results: Twenty-six percent of the subjects reported using VMS or DS. VMS were the most frequently consumed item (16.8%), followed by DS (10%), calcium (6.6%) and iron (1.8%). Women reported a higher consumption than men. In women, VMS, DS and calcium use increased and iron use decreased with age, whereas in men only VMS and calcium intake increased with age. Multivariate analysis showed female gender, being born in Switzerland, increased age, higher education and increased physical activity to be positively related with VMS and DS. On bivariate analysis, VMS and DS users presented more frequently with arthritis, anxiety, depression and osteoporosis, but on multivariate analysis only positive relationships between DS use and anxiety/depression (odds ratio (OR) ¼ 1.40; 95% confidence interval (CI): [1.16-1.70]) and calcium and osteoporosis (OR ¼ 10.6;.4]) were found. Conclusion: VMS and DS use is common in the population of Lausanne and associated with a better health profile. Calcium supplements are taken to prevent osteoporosis, whereas the rationale for taking other VMS and DS is unclear.

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Section: Discussionmentioning

confidence: 99%

Prevalence and characteristics of vitamin or dietary supplement users in Lausanne, Switzerland: the CoLaus study

et al. 2007

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“…59 The skeletal role of androgens upon cancellous bone is largely mediated by local aromatization into estrogens. 60 Androgen deficiency in men induces cancellous bone loss similar to estrogen deficiency in postmenopausal women. 60 In elderly men with hypogonadism, the resultant testosterone deficiency contributes to osteoporosis.…”

Section: Steroid Hormonesmentioning

confidence: 99%

“…60 Androgen deficiency in men induces cancellous bone loss similar to estrogen deficiency in postmenopausal women. 60 In elderly men with hypogonadism, the resultant testosterone deficiency contributes to osteoporosis. Although treatment of frank androgen deficiency with androgen replacement therapy is beneficial for bone, 61-63 the effect of androgen replacement on fracture incidence remains unknown.…”

Section: Steroid Hormonesmentioning

confidence: 99%

Understanding the Mechanisms of Senile Osteoporosis: New Facts for a Major Geriatric Syndrome

Duque

Troen

2008

J American Geriatrics Society

133

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Knowledge of the underlying mechanisms of osteoporosis in older adults has significantly advanced in recent years. There is an acute loss of bone mineral density in the peri-menopausal period, followed by a more gradual and progressive decline, which is also seen in men. Markedly increased bone resorption leads to the initial fall in bone mineral density. With increasing age, there is also a significant reduction in bone formation. This is mostly due to a shift from osteoblastogenesis to predominant adipogenesis in the bone marrow. This study reviews new evidence on the pathophysiology of senile osteoporosis, with emphasis upon the mechanism of action of current osteoporosis treatments. New potential treatments are also considered, including therapeutic approaches to osteoporosis in elderly people that focus on the pathophysiology and potential reversal of the adipogenic shift in bone.

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“…In addition, testosterone levels naturally decrease with age, and men being eugonadal in early adulthood can develop androgen deficiency in more advanced age (4). Men with severe hypogonadism face the risk of developing osteoporosis, depression, and disturbed metabolism that might lead to metabolic syndrome and type 2 diabetes, as well as cardiovascular diseases (5)(6)(7). In some studies, these conditions were shown to be ameliorated by testosterone replacement (8,9).…”

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confidence: 99%