Epidemiology and Predictors of Short-Term Mortality in Symptomatic Venous Thromboembolism  - A Nationwide Population-Based Study -

Lee, Cheng‐Han; Cheng, Ching Lan; Lin, Li Jen; Tsai, Liang Miin; Yang, Yea Huei Kao

doi:10.1253/circj.cj-10-0992

Cited by 62 publications

(58 citation statements)

References 24 publications

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“…The results agree with the literature, which reports the increased risk of thrombosis and/or thrombus formation with age, e.g., Anderson Jr et al (1991), Oger (2000), Rosendaal (1997), Lee et al (2011) andOrra (2002). When using the method of Wells et al (1995Wells et al ( , 1997, the two patients with thrombosis were rated at least moderate, which was consistent with the occurrence of thrombosis.…”

Section: Discussionsupporting

confidence: 92%

A novel method for predicting the risk of thrombosis and thromboembolism

Leite

Marques

2014

Rev. Bras. Eng. Bioméd.

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Introduction: Thrombosis is a complex disease that is often silent and is characterized by thrombus formation within the blood vessel. It can lead to a venous obstruction in the body, severe sequelae and even death. Thrombus formation occurs when there is reduced blood flow and/or the release of procoagulant substances caused by external factors. In Brazil, the data on this pathology are still underestimated, and its incidence is approximately 0.8 cases/1000 inhabitants per year according to the literature. The aim of this study was to develop and validate a predictive method for the risk of thrombosis or thromboembolism according to various risk factors. Methods: This is an observational and retrospective study based on a convenience sample of records. It was approved by the Institutional Review Board (IRB) of the University Mogi das Cruzes and the Heart Hospital of the São Paulo. The sample was classified according to the risk, and the assessment of concordance was performed by determining the Kappa coefficient and accuracy. Results: Of the observed patients, 23 (46%) were women, and 86% were over 45 years old. The mean age of the patients was 60.8 years. Forty-eight percent of the patients underwent surgery for more than 30 minutes. In this study, the method categorized 29 (58%) patients as moderate risk, 10 as low risk and 11 as high risk. Two cases of thrombotic disease were sufficient for validation. Conclusion: The use of this software as a predictive method was feasible, providing fast filling, immediate scoring, flexibility and an upgrade over previous systems. The software will not substitute for diagnosis, which is a medical competence, but it may help as a warning of risk.

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Section: Discussionsupporting

confidence: 92%

A novel method for predicting the risk of thrombosis and thromboembolism

Leite

Marques

2014

Rev. Bras. Eng. Bioméd.

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“…For HT nonusers, the index date was the date of the first medical visit during 2000-2008. countries. 17, 18 For women, the overall VTE recurrence rate was 10.1% vs. 11.4% (P=0.41) among HT users and nonusers, respectively. Meanwhile, there was no significant difference in the prevalence of HT use (including estrogen and/or progesterone) between VTE recurrent cases and VTE non-recurrent controls.…”

Section: Exposure Definitionmentioning

confidence: 93%

Hormone Therapy and Risk of Venous Thromboembolism Among Postmenopausal Women in Taiwan　– A 10-Year Nationwide Population-Based Study –

Lee

Cheng

Yang

et al. 2015

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp striking decrease in HT use has been noted, many women remain eligible for this treatment to correct postmenopausal climacteric symptoms and to prevent osteoporosis. Cardiovascular disease, including VTE, is an important determinant of the benefit-to-risk profile of HT. 9 Both observational studies 10-13 and clinical trials 2,14 have shown a significant increase in VTE risk among postmenopausal women using HT. However, most of these studies have been conducted in Caucasian women, so the results are not essentially generalizable to other races. According to Japan's guidelines for management and prevention of VTE, estrogen therapy is a weak risk factor of VTE, and there is no recommendation for HT in postmenopausal women. 15 Nakamura et al reported that estrogen or/and HT did not contribute to a higher risk of VTE recurrence, but their sample size was too small to make a definitive conclusion. 16 In our previous studies, the overall crude incidence of VTE was 14.4 events per 100,000 person-years in men and 17.4 events per 100,000 person-years in women, which was much lower (71-117 cases per 100,000 persons) than in Western ormone therapy (HT) can improve quality of life for women with hypo-estrogenic symptoms 1 and is also effective for preventing osteoporotic fractures among current users. 2,3 In contrast, harmful effects of HT include breast cancer and venous thromboembolism (VTE). 4 Furthermore, randomized controlled trials showed that HT might increase the risk of coronary artery disease and stroke. 2,5 Many women are still prescribed estrogen therapy to ameliorate postmenopausal symptoms despite recent data showing that overall health risks may exceed the benefits of long-term HT. 2 Despite evidence showing that oral estrogen activates blood coagulation in postmenopausal women, 6 HT had, until 1996, long been believed to have little effect on the risk of VTE. 7 Recent observational studies, however, have shown consistent associations between current use of HT and an increased risk of VTE in postmenopausal women. These findings have been confirmed in randomized controlled trials. 2,5 Since the publication of the Women's Health Initiative (WHI) results, 2 the medical practice of HT has been dramatically altered. The incidence of venous thromboembolism (VTE) in Asians is lower than in Caucasians, but the risk of VTE associated with hormone therapy (HT) in Taiwanese postmenopausal women has not been determined.

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“…12 In contrast, no seasonal distribution of VTE incidence has been otherwise identified, including in the Taiwanese population. 7 In addition, no relationship between VTE incidence and humidity, temperature, or atmospheric pressure has been confirmed, though the subtropical climate of Taiwan might have contributed to these findings. Another possible cause might be the hospital situation, without seasonal variations, given that approximately half of PE patients develop the disease while in hospital.…”

Section: Article P 1998mentioning

confidence: 94%

“…7 The incidence of VTE and PE among Taiwanese adults was 16.5 and 4.8 per 100,000, respectively. The incidence of VTE was lower in Taiwanese than among Caucasians and AfricanAmericans and was similar to that of other Asians according to comparisons with the reports described above.…”

Section: Article P 1998mentioning

confidence: 96%

“…10 The authors also showed that survivors of VTE have a lower primary hypercoagulable status, including these gene mutations, than non-survivors. 7 However, mutations of FVL and the thrombin gene are rare among African-Americans with VTE, 11 which obscures the contribution of these gene mutations to the incidence of VTE. Thus, in addition to genetic predisposition, differences in lifestyle traits, obesity and psychosocial stress might contribute to the development of VTE.…”

Section: Article P 1998mentioning

confidence: 99%

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Ethnicity of Patients With Venous Thromboembolism

Ikeda

Miyahara

2011

Circ J

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Epidemiology and Predictors of Short-Term Mortality in Symptomatic Venous Thromboembolism - A Nationwide Population-Based Study -

Cited by 62 publications

References 24 publications

A novel method for predicting the risk of thrombosis and thromboembolism

A novel method for predicting the risk of thrombosis and thromboembolism

Hormone Therapy and Risk of Venous Thromboembolism Among Postmenopausal Women in Taiwan　– A 10-Year Nationwide Population-Based Study –

Ethnicity of Patients With Venous Thromboembolism

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Epidemiology and Predictors of Short-Term Mortality in Symptomatic Venous Thromboembolism - A Nationwide Population-Based Study -

Cited by 62 publications

References 24 publications

A novel method for predicting the risk of thrombosis and thromboembolism

A novel method for predicting the risk of thrombosis and thromboembolism

Hormone Therapy and Risk of Venous Thromboembolism Among Postmenopausal Women in Taiwan – A 10-Year Nationwide Population-Based Study –

Ethnicity of Patients With Venous Thromboembolism

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Hormone Therapy and Risk of Venous Thromboembolism Among Postmenopausal Women in Taiwan　– A 10-Year Nationwide Population-Based Study –