Epidemiology and Prospects for Prevention of Pancreatic Cancer

Jiao, Li; Li, Donghui

doi:10.1007/978-0-387-77498-5_1

Cited by 6 publications

(5 citation statements)

References 138 publications

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“…In 2010, pancreatic cancer was the 5th most common cause of cancer death in Australia. The incidence and mortality statistics of pancreatic cancer are similar throughout the world …”

Section: Introductionmentioning

confidence: 99%

“…The incidence and mortality statistics of pancreatic cancer are similar throughout the world. [21] There is little direct scientific evidence linking the prospective application of eucalypt-derived bioactive compounds in the management of pancreatic cancer. In this study, four eucalypt species (A. hispida, A. floribunda, C. citriodora, and C. maculata) belonging to the two least explored genera (Angophora and Corymbia) were studied and their phytochemical profile and anticancer activity against both primary and secondary pancreatic adenocarcinoma cells evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Least Studied Australian Eucalypt Genera: Corymbia and Angophora for Phytochemicals with Anticancer Activity against Pancreatic Malignancies

Bhuyan

Vuong

Bond

et al. 2017

Chemistry & Biodiversity

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While the pharmacological and toxicological properties of eucalypts are well known in indigenous Australian medicinal practice, investigations of the bioactivity of eucalypt extracts against high mortality diseases such as pancreatic cancer in Western medicine have to date been limited, particularly amongst the genera Corymbia and Angophora. Four Angophora and Corymbia species were evaluated for their phytochemical profile and efficacy against both primary and secondary pancreatic cancer cell lines. The aqueous leaf extract of Angophora hispida exhibited statistically higher total phenolic content (107.85 ± 1.46 mg of gallic acid equiv. per g) and total flavonoid content (57.96 ± 1.93 mg rutin equiv. per g) and antioxidant capacity compared to the other tested eucalypts (P < 0.05). Both A. hispida and A. floribunda aqueous extracts showed statistically similar saponin contents. Angophora floribunda extract exerted significantly greater cell growth inhibition of 77.91 ± 4.93% followed by A. hispida with 62.04 ± 7.47% (P < 0.05) at 100 μg/ml in MIA PaCa-2 cells with IC values of 75.58 and 87.28 μg/ml, respectively. More studies are required to isolate and identify the bioactive compounds from these two Angophora species and to determine their mode of action against pancreatic malignancies.

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“…In 2010, pancreatic cancer was the 5th most common cause of cancer death in Australia. The incidence and mortality statistics of pancreatic cancer are similar throughout the world …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Least Studied Australian Eucalypt Genera: Corymbia and Angophora for Phytochemicals with Anticancer Activity against Pancreatic Malignancies

Bhuyan

Vuong

Bond

et al. 2017

Chemistry & Biodiversity

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“…A number of risk factors have been identified for pancreatic cancer, including gender, ethnicity and history of chronic pancreatitis (2). The greatest environmental risk factor for pancreatic cancer is cigarette smoking (2).…”

Section: Introductionmentioning

confidence: 99%

“…The greatest environmental risk factor for pancreatic cancer is cigarette smoking (2). The relative risk for cigarette smoking is between 2 and 3 fold, but can be higher in heavy smokers, suggesting a dose-response association (2).…”

Section: Introductionmentioning

confidence: 99%

“…Components of cigarette smoke likely reach the pancreas through the general circulation, but also may come from the GI tract through reflux. The chemical component(s) of cigarette smoke that are responsible for increasing pancreatic cancer risk are not known, although some evidence supports a role for aromatic amines or N-nitroso compounds (2). The molecular mechanisms of the enhancement of pancreatic cancer by cigarette smoke are not understood.…”

Section: Introductionmentioning

confidence: 99%

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Effect of cigarette smoke exposure and mutant Kras overexpression on pancreatic cell proliferation

et al. 2017

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Abstract. Pancreatic cancer is the fourth leading cause of cancer-associated mortality. The major risk factor for pancreatic cancer is cigarette smoking. Kras mutations are commonly observed in human pancreatic cancers. The present study examined the hypothesis that exposure to cigarette smoke and overexpression of a mutant Kras gene in the pancreas affects pancreatic cell proliferation in mice. Mice overexpressing the mutant Kras gene (KRas G12D ) in the pancreas as well as wild-type mice were exposed to environmental tobacco smoke for 2 weeks. Overexpression of mutant Kras increased cell proliferation in pancreatic ductal, acinar and islet cells. Notably, cigarette smoke exposure decreased cell proliferation in pancreatic ductal and acinar cells, and had no effect in islet cells. Cigarette smoke did not affect pancreatic protein levels of tumor necrosis factor (TNF)α, p53, or cyclin D 1 , but mutant Kras overexpression slightly decreased TNFα and p53 protein levels. Therefore, pancreatic cell proliferation in mice overexpressing mutant Kras is associated with the later development of pancreatic tumors, but effects of cigarette smoke on pancreatic cell proliferation do not provide a good model for human pancreatic carcinogenesis.

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