Epidemiology and risk factors for bronchopulmonary dysplasia in preterm infants born at or less than 32 weeks of gestation

Alonso, Andrea Sucasas; Díaz, Sonia Pértega; Soto, Rebeca Sáez; Ávila-Álvarez, Alejandro

doi:10.1016/j.anpede.2021.03.006

Cited by 18 publications

(17 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The founding of this study showed that GA and intrauterine infection were independent risk factors for BPD which was partially consistent with the study by Alonso et al ( 14 ) on 202 VLBWI in which GA, the application of invasive MV within 1 day after birth, and the presence of nosocomial infection were identified as the main risk factors for the development of BPD.…”

Section: Discussionsupporting

confidence: 92%

Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants

Zhu

Liu

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

ObjectiveThis study aimed to determine the influence of fluid overload on bronchopulmonary dysplasia (BPD) in very low-birth-weight infants (VLBWI) within 1 week after birth.MethodsThis was a retrospective case control study conducted in the Jingzhou Central Hospital. The clinical data of VLBWI (with a birth weight [BW] < 1,500 g and 26 weeks ≤ gestational age [GA] < 32 weeks) who were admitted to the neonatal intensive care unit of this hospital from January 2016 to December 2021 were analyzed retrospectively. A total of 157 cases were enrolled and divided into a BPD group (n = 60) and a non-BPD group (n = 97) according to whether BPD was present. The general condition, fluid intake, and fluid overload of the two groups of neonates within 1 week after birth were compared. The logistic regression was used to assess the association between infant characteristics and BPD. The ROC curve was used to assess how well the 7 day cumulative fluid overload predicted BPD, and to identify an optimal cut off for prediction.ResultsThe comparison of the patients' general condition revealed that the neonates in the BPD group had a younger GA, lower BW, lower 5-min Apgar score, longer duration of invasive mechanical ventilation, and higher incidence of intrauterine infections and administration of surfactants (P < 0.05). The differences in the other indicators were not statistically significant between the two groups. The logistic regression analysis revealed that a younger GA, the presence of intrauterine infection, and a 7-day cumulative fluid overload were the risk factors for the development of BPD. A ROC curve was plotted with the 7-day cumulative fluid overload as the test variable and BPD as the status variable. The area under the curve was 0.75 (95% confidence interval: 0.664–0.826, P = 0.042), with a sensitivity of 76.7% and a specificity of 70.1%, corresponding to a 7-day cumulative fluid overload of 36.2%.ConclusionA younger GA, the presence of intrauterine infection, and a 7-day cumulative fluid overload were risk factors for the development of BPD. A 7 day cumulative fluid overload threshold of 36.2% best predicted the development of BPD.

show abstract

Section: Discussionsupporting

confidence: 92%

Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants

Zhu

Liu

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…Mechanical ventilation is an essential treatment strategy in the management of preterm infants; however, there is increasing recognition that their lungs are particularly susceptible to ventilatory-induced lung injury ( 8 ), and the need for mechanical ventilation is a well-known risk factor for the development of BPD( 76 , 77 ). Early mechanical ventilation in neonatal mice recapitulates the BPD phenotype of abnormal alveolar development with larger, fewer alveoli, increased elastin redistribution throughout the distal airspaces, and increased apoptosis ( 78 – 81 ).…”

Section: Effect Of Postnatal Bpd Risk Factors On Tgf-β Signalingmentioning

confidence: 99%

Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia

Calthorpe

Poulter

Smyth

et al. 2023

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular and neurological morbidity. Transforming growth factor beta (TGF-b) is an important signaling pathway in lung development, organ injury and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-b in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-b signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-b signaling.

show abstract

“…The stage of the microwave module (radiation) works with a non-ionizing signal and with a defined intensity level, this frequency in which it transmits the signal is conducted by a signal shadow that is reduced so that the electromagnetic chord with other mechanisms is not affected and several mechanisms can work at the same time and in the same bandwidth [20]. The operation of the microwave module can be seen in figure 2 by developing its diagram.…”

Section: A Microwave Modulementioning

confidence: 99%

Automatic System for Detecting Pathologies in the Respiratory System for the Care of Patients with Bronchial Asthma Visualized by Computerized Radiography

Meneses-Claudio

Perez-Siguas²,

Matta-Solís³

et al. 2023

IJRITCC

View full text Add to dashboard Cite

COVID-19 is a disease that directly affects the respiratory tract, being harmful in asthmatic patients because this condition causes a lack of oxygen, even to the extent that it requires external equipment to combat drowning. Likewise, it highlights the importance of maintaining a treatment or therapy correctly to prevent your disease from worsening or being exposed to other diseases, putting your health at risk. The diseases that asthmatic patients can acquire can result from pathologies, which have been growing over the years due to lack of equipment or efficient examinations that generate complete information about respiratory conditions about asthmatic patients, therefore, by developing an advanced system, the chances of detecting pathologies prematurely increase considerably, which is an essential tool today. According to the problem exposed, in this research an automatic system of detection of pathologies in the respiratory system was carried out for the care of the patient with bronchial asthma visualized by computerized radiography, so that any pathology can be detected by means of a premature diagnosis in the respiratory system and the doctor can perform a correct treatment on the asthmatic patient. Through the tests carried out by the system, its performance was accurate and efficient, being suitable to be implemented in various hospitals so that the doctor can treat the disease in time, since the system presented a 98.79% efficiency in the detection of pathologies.

show abstract

Epidemiology and risk factors for bronchopulmonary dysplasia in preterm infants born at or less than 32 weeks of gestation

Cited by 18 publications

References 36 publications

Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants

Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants

Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia

Automatic System for Detecting Pathologies in the Respiratory System for the Care of Patients with Bronchial Asthma Visualized by Computerized Radiography

Contact Info

Product

Resources

About