Epidemiology and risk factors: intrahepatic cholangiocarcinoma

Gupta, Amar; Dixon, Elijah

doi:10.21037/hbsn.2017.01.02

Cited by 142 publications

(101 citation statements)

References 26 publications

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“…Incidence of ICC is rapidly increasing worldwide and accounts for 10%-20% of primary hepatic cancers (Gupta and Dixon 2017), and ICC is associated with a poorer 5-yr survival rate than HCC (Lang et al 2007;Rizvi and Gores 2013). We analyzed tumor/nontumor sample pairs from 10 ICC patients by RCseq and ∼40× WGS.…”

Section: A D C Bmentioning

confidence: 99%

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

et al. 2018

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The retrotransposon Long Interspersed Element 1 (LINE-1 or L1) is a continuing source of germline and somatic mutagenesis in mammals. Deregulated L1 activity is a hallmark of cancer, and L1 mutagenesis has been described in numerous human malignancies. We previously employed retrotransposon capture sequencing (RC-seq) to analyze hepatocellular carcinoma (HCC) samples from patients infected with hepatitis B or hepatitis C virus and identified L1 variants responsible for activating oncogenic pathways. Here, we have applied RC-seq and whole-genome sequencing (WGS) to an Abcb4 (Mdr2)−/− mouse model of hepatic carcinogenesis and demonstrated for the first time that L1 mobilization occurs in murine tumors. In 12 HCC nodules obtained from 10 animals, we validated four somatic L1 insertions by PCR and capillary sequencing, including T F subfamily elements, and one G F subfamily example. One of the T F insertions carried a 3 ′ transduction, allowing us to identify its donor L1 and to demonstrate that this full-length T F element retained retrotransposition capacity in cultured cancer cells. Using RC-seq, we also identified eight tumor-specific L1 insertions from 25 HCC patients with a history of alcohol abuse. Finally, we used RC-seq and WGS to identify three tumor-specific L1 insertions among 10 intra-hepatic cholangiocarcinoma (ICC) patients, including one insertion traced to a donor L1 on Chromosome 22 known to be highly active in other cancers. This study reveals L1 mobilization as a common feature of hepatocarcinogenesis in mammals, demonstrating that the phenomenon is not restricted to human viral HCC etiologies and is encountered in murine liver tumors.

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Section: A D C Bmentioning

confidence: 99%

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

et al. 2018

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“…Although not identified in all cases, many risk factors for CCA development, whether infectious or otherwise, indicate a common pathogenesis pathway, the development of chronic biliary inflammation. 11,26,27 Liver infection by flukes Clonorchis sinensis and Opisthorchis viverrinin is an important risk factor in Southeast Asia, particularly in Thailand, where CCA is the main primary liver cancer. According to the International Agency for Research on Cancer, infection with C. sinensis or O. viverrinin with subsequent development of chronic bile duct inflammation is recognized as carcinogen type I and is probably carcinogenic to humans, respectively.…”

Section: Risk Factorsmentioning

confidence: 99%

“…This disease is characterized by chronic inflammation of bile ducts and consequently biliary strictures that could evolve to cirrhosis and the development of CCA, mainly mucinous iCCA. 26,29,30 Moreover, other biliary tract diseases such as congenital biliary tract malformations, hepatolithiasis, and cystic fibrosis have been associated with CCA risk. 11,26,27 Other risk factors such as alcohol liver disease, tobacco smoking, and exposure to the radiopaque medium Thorotrast, 1,2dichloropropane, and dichloromethane have also been associated.…”

Section: Risk Factorsmentioning

confidence: 99%

“…26,29,30 Moreover, other biliary tract diseases such as congenital biliary tract malformations, hepatolithiasis, and cystic fibrosis have been associated with CCA risk. 11,26,27 Other risk factors such as alcohol liver disease, tobacco smoking, and exposure to the radiopaque medium Thorotrast, 1,2dichloropropane, and dichloromethane have also been associated. 11,26,27 Furthermore, viral hepatitis has been proposed as a CCA risk factor, in particular mixed iCCA.…”

Section: Risk Factorsmentioning

confidence: 99%

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Hepatitis C Virus Infection and Cholangiocarcinoma

Navas

Glaser

Dhruv

et al. 2019

The American Journal of Pathology

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Hepatitis C virus (HCV) infection is a global public health problem because it is a main cause of liver cirrhosis and hepatocellular carcinoma. This human oncogenic virus is also associated with the development of non-Hodgkin lymphoma and cholangiocarcinoma (CCA). The association between HCV infection and CCA has been examined in a number of epidemiologic studies. However, in vivo and in vitro results demonstrating the oncogenic mechanisms of HCV in CCA development and progression are insufficient. Here, we review the epidemiologic association of HCV and CCA and recent publications of studies of HCV infection of cholangiocytes and CCA cell lines as well as studies of viral infection performed with liver samples obtained from patients. In addition, we also discuss the preliminary results of in vitro assays of HCV protein expression in CCA cell lines. Finally, we discuss the hypothetical role of HCV infection in CCA development by induction of epithelialemesenchymal transition and up-regulation of hedgehog signaling, and consequently biliary tree inflammation and liver fibrosis. Further studies are required to demonstrate these hypotheses and therefore to elucidate the mechanisms of HCV as a risk factor for CCA.

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“…1,2 ICC accounts for up to 8-10% of all cholangiocarcinomas and 10-20% of all primary liver tumors. 1 Mortality from ICC has risen globally, 2 and recent data have indicated that the occurrence of ICC on cirrhosis is increasing. 1,2 ICC is considered more aggressive than hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Intrahepatic Cholangiocarcinoma and Thermal Ablation: Long-term Results of An Italian Retrospective Multicenter Study

Giorgio¹,

Gatti²,

Montesarchio³

et al. 2019

Journal of Clinical and Translational Hepatology

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Background and Aims: Despite resection being considered the treatment of choice for intrahepatic cholangiocarcinoma (ICC), percutaneous thermal ablation can be an alternative treatment for patients unfit for surgery. Our aim was to compare long-term results of percutaneous sonographically-guided radiofrequency ablation (RFA) with highpowered microwave ablation (MWSA) in treatment of ICC. Methods: Results of 71 ICC patients with 98 nodules treated with RFA (36 patients) or MWSA (35 patients) between January 2008 and June 2018 in 5 Interventional Ultrasound centers of Southern Italy were retrospectively reviewed. Cumulative overall survival curves were calculated with the Kaplan-Meyer method and differences with the log-rank test. Eleven possible factors affecting survival were analyzed. Results: Overall survival of the entire series was 88%, 65%, 45% and 34% at 12, 36, 60 and 80 months, respectively. Patients treated with MWSA survived longer than patients treated with RFA (p < 0.005). The MWSA group with ICC nodules #3 cm or nodules up to 4 cm survived longer than the RFA group (p < 0.0005). In patients with nodules >4 cm, no significant difference was found. Disease-free survival and progression-free survival were better in the MWSA group compared to the RFA group (p < 0.005). Diameter of nodules and MWSA were independent factors predicting a better survival. No major complications were observed. Conclusions: MWSA is superior to RFA in treating ICC unfit for surgery, achieving better long-term survival in small (#3 cm) ICC nodules as well as nodules up to 4 cm of neoplastic tumors and should replace RFA. Citation of this article: GiorgioA, Gatti P, Montesarchio L, Santoro B, Dell'Olio A, Crucinio N, et al. Intrahepatic cholangiocarcinoma and thermal ablation: long-term results of an Italian retrospective multicenter study.

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Epidemiology and risk factors: intrahepatic cholangiocarcinoma

Cited by 142 publications

References 26 publications

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

Hepatitis C Virus Infection and Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma and Thermal Ablation: Long-term Results of An Italian Retrospective Multicenter Study

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