Epidemiology and risk of colorectal cancer in patients with a history of Helicobacter pylori infection: a population-based study

Abstract

Background Numerous modifiable risk factors have been associated with colon cancer. Helicobacter pylori ( H. pylori ) is the most common bacterial infection worldwide and the strongest known risk factor for gastric cancer. We aim to assess whether the risk of colorectal cancer (CRC) is higher in patients with a history of H. pylori infection. Methods A validated multicenter and research platform database of more than 360 hospitals was queried. Patients aged 18-65 years were included in our cohort. We excluded all patients who had previously had a diagnosis of inflammatory bowel disease or celiac disease. Univariate and multivariate regression analyses were used to calculate CRC risk. Results A total of 47,714,750 patients were selected after application of the inclusion and exclusion criteria. The 20-year-period prevalence rate of CRC in the United States population from 1999 to September 2022 was 370 of 100,000 individuals (0.37%). According to multivariate analysis, the risk of CRC was higher in smokers (odds ratio [OR] 2.52, 95% confidence interval [CI] 2.47-2.57), obese patients (OR 2.26, 95%CI 2.22-2.30), those with irritable bowel syndrome (OR 2.02, 95%CI 1.94-2.09), or type 2 diabetes mellitus (OR 2.89, 95%CI 2.84-2.95), and patients who had a diagnosis of H. pylori infection (OR 1.89, 95%CI 1.69-2.10). Conclusion We provide the first evidence from a large population-based study demonstrating an independent association between a history of H. pylori infection and CRC risk.

Non‐alcoholic steatohepatitis is independently associated with a history of gestational diabetes mellitus

“…Moreover, our study is limited by the fact that the definition of NASH and GDM could have been heterogeneous across different United States centers. Despite its limitations, Explorys platform has been validated as a database in several different fields including gastroenterology and endocrinology 11,12,24–26 . It is also an excellent research tool that provides clinicians with fruitful resources to investigate disease epidemiology and burden on a large population scale.…”

“…Despite its limitations, Explorys platform has been validated as a database in several different fields including gastroenterology and endocrinology. 11,12,[24][25][26] It is also an excellent research tool that provides clinicians with fruitful resources to investigate disease epidemiology and burden on a large population scale.…”

Prevalence and Risk Factors Associated with Upper Gastrointestinal Malignancies in Post-Menopausal Patients on Hormone Replacement Therapy: A Population-Based Study

“…The Institutional Review Board is not required because Explorys is a platform that complies with the Health Insurance Portability and Accountability Act (HIPAA). The use of this database has been approved in a number of specialties, including gastroenterology, hematology, and cardiology [7][8][9][10][11].…”

Effects of Helicobacter pylori infection on intestinal microbiota, immunity and colorectal cancer risk

“…Finally, the up-to-date greatest retrospective population-based study from the USA reported an independent positive association between the history of H. pylori infection status and CRC development with an OR of 1.89. However, as the H. pylori status was determined based on serological testing, the authors could not differentiate between active or past infection and thus explore the effects of eradication therapy on CRC risk (Boustany et al, 2023).…”