Epidemiology and survival of childhood cancer in Turkey

Kebudi, Rejin; Alkaya, Dilek Uludağ

doi:10.1002/pbc.28754

Cited by 25 publications

(12 citation statements)

References 17 publications

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“…The pooled estimate in 2010-20 was 6% (0-20, I²=98%) for LICs, 34% (21-49, I²=99%) for LMICs, 47% (38-56, I²=96%) for UMICs, and 70% (60-80, I²=96%) for HICs (table 2; appendix p 8). Globally, the pooled estimate improved significantly, from 22% [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] in 1980-89 to 44% [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] in 2010-20 (p=0•017).…”

Section: Resultsmentioning

confidence: 99%

“…The globe salvage rates of advanced intraocular stage retinoblastoma were pooled and stratified by income level. Higher globe salvage rates for advanced intraocular disease were associated with higher income level, with UMICs improving from 31% in 2000-09 to 42% (33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51) in 2010-20 and HICs improving from 27% in 2000-09 to 57% (42-72; table 2) in 2010-20. Sparse data were available in LICs and a widening disparity is seen compared with LMICs.…”

Section: Resultsmentioning

confidence: 99%

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Global retinoblastoma survival and globe preservation: a systematic review and meta-analysis of associations with socioeconomic and health-care factors

Wong

Choy

Zhang

et al. 2022

The Lancet Global Health

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Background Despite advancements in globe-preserving treatments, improvements in retinoblastoma outcomes are inconsistent across income levels and geographical locations. We aimed to investigate trends in global retinoblastoma survival and globe preservation during the past 40 years. We also examined associated socioeconomic and health-care factors and global survival disparity. MethodsWe did a systematic review and meta-analysis by screening articles in any language in nine databases (PubMed, Embase, ScienceDirect, Web of Science, OpenGrey, Global Burden of Disease, Global Health Data Exchange, Global Index Medicus, and International Agency for the Prevention of Blindness) published between Jan 1, 1981, and Oct 8, 2021. We screened for articles that described retinoblastoma overall survival or globe salvage, or both. All reported studies were subsequently stratified into four periods: 1980-89, 1990-99, 2000-09, and 2010-20. Indicators on socioeconomic and health-care factors were extracted from the World Bank and WHO. Ophthalmology-related indicators were further parsed from the International Agency for the Prevention of Blindness. Between-study heterogeneities by income level were assessed by mixed-effect meta-analysis. Associations of retinoblastoma outcome with socioeconomic and health-care factors and factors for survival prediction were investigated by multivariable linear regressions. This study is registered with PROSPERO, number CRD42020221556. Findings Our search identified 14 621 articles, of which 314 studies were included for analysis after screening, including 38 130 patients from 80 regions globally presenting during 1980-2020. 255 articles were entered for timetrend meta-analysis, covering 29 106 patients from 73 countries. Both overall survival (from 79% [95% CI 74-84] to 88% [83-93]; p=0•017) and globe salvage rate (from 22% [14-32] to 44% [36-52]; p=0•0003) improved significantly over the four decades. Wide disparities were observed between higher-income and lower-income countries. Overall survival, globe salvage, and globe salvage for advanced intraocular disease correlated positively with income level. Higher overall survival was associated with lower Gini index (p=0•0001) and with populations that had smaller percentages living in rural areas (p=0•0005). Higher globe salvage was associated with better health-care financing and accessibility (p=0•030). Overall survival (p=0•0024) and globe salvage (p=0•022) were both associated positively with education level. Survival gaps were observed in sub-Saharan Africa and southeast and southwest Asia.Interpretation Retinoblastoma treatment outcomes have improved globally over the past four decades but large disparities persist between higher-income and lower-income countries, with some areas having major survival gaps. Targeted health-care policy making with increased health-care financing and accessibility are needed in low-income and lower-middle-income countries to improve retinoblastoma outcomes worldwide.Funding Health and Medical Research Fund (H...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Global retinoblastoma survival and globe preservation: a systematic review and meta-analysis of associations with socioeconomic and health-care factors

Wong

Choy

Zhang

et al. 2022

The Lancet Global Health

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“…The incidence is less than one case per 100,000 persons in the United States, whereas in endemic areas, such as in the southern regions of China, Singapore, and Malasia its incidence is> 15–50 cases per 100,000 persons 5 . In our center, NPC constitutes 3.2% of all childhood malignancies 6 …”

Section: Introductionmentioning

confidence: 75%

“…5 In our center, NPC constitutes 3.2% of all childhood malignancies. 6 Treatment strategy has been adopted from guidelines in adults, which mainly consists of radiotherapy (RT) to the nasopharynx and involved lymph nodes of the neck, and a moderate dose of radiation to uninvolved cervical lymph nodes and surrounding tissue. 7,8 Combined RT with chemotherapy has been reported to reduce locoregional or systemic relapse, and long-term survival has increased to more than 80% in most pediatric series.…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal carcinoma in children: Multimodal treatment and long‐term outcome of 92 patients in a single center over a 28‐year period

Kebudi

Buyukkapu

Görgün

et al. 2021

Pediatric Blood & Cancer

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Objectives:The aim of the study was to evaluate the long-term outcome and late effects in pediatric patients with nasopharyngeal carcinoma (NPC) treated with neoadjuvant chemotherapy (NACT), followed by radiotherapy (RT).Methods: Ninety-two children (65 male, 27 female) diagnosed with NPC between 1989 and 2017 in the Istanbul University, Institute of Oncology were evaluated retrospectively. NACT consisted of three cycles of cisplatin-containing regimen every 3 weeks, followed by RT. Results:The median age was 13 years (5-18 years). Most had locoregionally advanced disease (stage III/IVA/IVB) and five had distant metastases at presentation. At a median follow-up of 108 months (3-332 months), 5-and 10-year overall survival rates and event-free survival rates were 87.5%, 79.7% and 82.1%, 78.9%, respectively. Three patients with distant metastasis are long-term survivors. Thirteen patients relapsed at a median of 8 months (2-23 months). Hypothyroidism (36%) and xerostomia (25%) were the most frequent long-term treatment-related toxicities. Nine second malignancies developed in eight patients, eight in the irradiated field at a median of 14 years (range 5-26 years), five of whom are long-term survivors after curative surgery.Conclusions: Three courses of cisplatin-containing NACT, followed by RT lead to high survival and locoregional control rate in advanced stage NPC in children. Patients with distant metastasis should also be treated with curative intent by systemic chemotherapy and locoregional radiotherapy. Patients should be followed closely for recurrences and long-term morbidities including second malignancies, which may be treated with curative surgeries if diagnosed early.

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“… 4 Through the new developments in diagnosis and treatment methods, mortality and morbidity rates in childhood cancers have decreased compared to previous years. 5 The most critical reasons for this situation can be listed as new imaging methods, the histopathological definition of new cancer types, genetic mutations detected in cancerous tissue, surgical methods, targeted therapies in chemotherapy, new chemotherapy agents, and developments in the field of radiotherapy. Cancers in children differ from adults as they have a higher growth rate and are more aggressive.…”

Section: Introductionmentioning

confidence: 99%

Any Concern About Delays in the Diagnosis of Childhood Cancers During the COVID-19 Pandemic?

Koç

Tekkeşin

Haccaloğlu

et al. 2023

Turk Arch Pediatrics

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Objective: The lockdown precautions during the COVID-19 pandemic led to concerns about the delayed diagnosis of malignancies. This study aimed to compare the duration of complaints at home and the presence of metastasis at diagnosis during the pre-pandemic and pandemic period in children with cancer. Materials and Methods: All children diagnosed with cancer and followed up in our clinic between 2017 and 2022 were included. Patients with a diagnosis of acute/chronic leukemia were excluded. Age, gender, cancer type, duration of complaints, and presence of metastasis at diagnosis of the children were recorded. The duration of complaints and presence of metastasis at diagnosis were compared statistically before and after March 11, 2020, the start point of the COVID-19 pandemic in our country. Results: A total of 161 patients diagnosed with cancer were analyzed retrospectively; 61% of patients were males and 39% were females. These patients were diagnosed with brain tumors (23.6%), lymphomas (23%), neuroblastoma (13.7%), rhabdomyosarcomas (10.6%), Ewing’s sarcoma (4.3%), osteosarcoma (3.7%), Wilm's tumor (3.7%), and germ cell tumors (3.1%). The duration of complaint was longer during the pandemic than before the pandemic (median: 45 days vs. 30 days) ( P < .05). The presence of metastases at diagnosis was 45.3% in the pre-pandemic period, while it was 40% during the pandemic with no statistical difference ( P > .5). Conclusion: We concluded that the duration of complaint before diagnosis was longer during the pandemic, while this delay did not affect the metastasis rate at diagnosis in children with cancer. The high rates of distant metastases in newly diagnosed patients both before and during the pandemic suggest that more studies are needed to diagnose these patients earlier.

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Epidemiology and survival of childhood cancer in Turkey

Abstract: Introduction: The aim of this study is to evaluate demographics, clinical data, and survival rates of children with cancer over 22 years, and to compare the outcomes, before and after a national health reform was performed.

Cited by 25 publications

References 17 publications

Global retinoblastoma survival and globe preservation: a systematic review and meta-analysis of associations with socioeconomic and health-care factors

Global retinoblastoma survival and globe preservation: a systematic review and meta-analysis of associations with socioeconomic and health-care factors

Nasopharyngeal carcinoma in children: Multimodal treatment and long‐term outcome of 92 patients in a single center over a 28‐year period

Any Concern About Delays in the Diagnosis of Childhood Cancers During the COVID-19 Pandemic?

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