Epidemiology and Survival of Hepatocellular Carcinoma in Turkey: Outcome of Multicenter Study

Alacacıoğlu, Ahmet; Somali, İşıl; Şımşek, İlkay; Astarcıoğlu, İbrahim; Özkan, Metin; Camcı, Celaletdin; Alkış, Necati; Karaoğlu, Aziz; Tarhan, Oktay; Ünek, Tarkan; Yılmaz, Uğur

doi:10.1093/jjco/hyn082

Cited by 43 publications

(52 citation statements)

References 12 publications

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“…Chronic infection with hepatitis often results in cirrhosis and enhances the probability of developing HCC, with no identified etiologic factors in majority of cases [19]. Since, viral load is considered as a strong predictor the disease progression in chronic hepatitis, identifying the status of circulating biomarkers in correlation to viral load might provide crucial clinical implications in disease management.…”

Section: Discussionmentioning

confidence: 99%

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections

et al. 2011

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The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections. Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however, role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma.

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Section: Discussionmentioning

confidence: 99%

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections

et al. 2011

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“…The incidence of HCC shows geographical variability, it is most frequent in southeast Asia and subSahara Africa that have more than 15 cases per 100000 population per year, less frequent in western countries (Beasley et al, 1981;Parkin, 2000;. According to Ministry of Health report that was published in 2003, the HCC incidence of in Turkey was 0.83/100000 (Alacacioglu et al, 2008). In Asia and Africa, high incidence rate of HCC have been associated both high endemic hepatitis B carrier rates as well as mycotoxin contamination of foodstuffs, stored grains, drinking water, and soil (Yue, 1995;Ueno et al, 1996;Fattovich et al,1997).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Characteristics of Hepatocellular Carcinoma in Turkey

Doğan¹,

Yalçın²,

Koca³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…[14] Benzer diğer çalışmalarda hastaların ortanca yaşam süresi 14 ay ve 19 ay olarak tespit edilmiş-tir. [15,16] Ortalama takip süresi 10.3 ay ve genel sağ kalım ortancası 5.5 ay olarak bulundu. Bizim çalış-mamızda ortanca yaşam süresi diğer çalışmalardan daha düşük çıkmıştır.…”

Section: Discussionunclassified

“…[18] Alacacioglu ve ark.nın yaptığı ça-lışmada cerrahi yapılanlarda prognoz diğer gruplara göre daha iyi tespit edilmiştir. [16] ABD'de yapılan bir çalışmada en iyi yaşam süresi 45 ay ile, cerrahi ile sağlanmış; aynı çalışmada lokal tedavi ile ortanca yaşam süresi 14 ay iken, tedavi almayan ve KT alanlarda kısa, sırasıyla iki ve dört ay olarak saptanmıştır. [14] Bizim çalışmamızda hastaların %34.7'si tedavisiz izlenmiş, %41.5'i KT almış, %15'ine lokal tedavi yapılmış, %8.8'ine de cerrahi yapılmıştır.…”

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Clinical features and prognostic factors of hepatocellular carcinoma patients; single center experience

Alanlı¹

2013

TJ Oncol

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OBJECTIVESWe aimed to evaluate the etiologic, demographic factors, clinical features and also prognostic factors which effect the survival of hepatocellular cancer (HCC) patients. METHODSWe retrospectively analyzed 213 HCC patients who were diagnosed at medical oncology clinic. RESULTSFourth (18.8%) chronic alcoholic, 142 (66.7%) hepatitis B, and 26 (12.2%) patients were hepatitis C. Median overall survival was 5.5 months (95% CI: 3.5-7.5). We detected statically significant effect of ECOG performance status, Child-Pugh score, portal venous thrombosis, levels of albumin, bilirubin, AST and AFP, presence of cirrhosis and the choice of treatment modality on overall survival. Assessment of response to first-line chemotherapy, 65 (91.5%) patients had progressive disease, two (2.8%) patients had stable disease, four (5.6%) patients had a partial response. CONCLUSIONViral hepatitis is the major leading etiological factors of HCC in our country. Despite all efforts, shorter life spans and cytotoxic therapies are not effective in this disease.Key words: Hepatocellular cancer; prognostic factors; survival. AMAÇHepatoselüler kanser (HSK) tanısı almış olan hastaların etiyolojik, demografik, klinik özelliklerin ve sağkalıma etki eden prognostik faktörlerin incelenmesi amaçlandı. GEREÇ VE YÖNTEMTıbbi Onkoloji Kliniği'ne başvuran HSK tanılı 213 hasta geriye dönük olarak incelendi. BULGULARKırk (%18.8) hastada alkol öyküsü, 142 (%66.7) hastada hepatit B, 26 (%12.2) hastada ise hepatit C öyküsü mevcuttu. Ortanca genel sağkalım 5.5 ay (%95 GA: 3.5-7.5) olarak bulundu. Genel sağkalım üzerinde; ECOG performans durumu, Child-Pugh skoru, portal ven trombozu, AFP düzeyi, siroz varlığı, albümin, bilirubin, AST düzeyleri ile tedavi seçiminin istatiksel anlamlı etkisi gözlendi. Birinci basamak kemoterapi yanıt değerlendirilmesinde; 65 (%91.5) hastada progresif hastalık, 2 (%2.8) hastada kararlı hastalık, 4 (%5.6) hastada parsiyel yanıt saptandı. SONUÇGelişmekte olan ülkelerde olduğu gibi ülkemizde de HSK etiyolojisinde viral hepatitler önemli rol oynamaktadır. Tüm çabalara rağmen bu hastalıkta yaşam süreleri kısadır ve sitotoksik tedaviler etkili değildir.Anahtar sözcükler: Hepatoselüler karsinom; prognoz; sağkalım.

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Epidemiology and Survival of Hepatocellular Carcinoma in Turkey: Outcome of Multicenter Study

Cited by 43 publications

References 12 publications

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections

Clinicopathological Characteristics of Hepatocellular Carcinoma in Turkey

Clinical features and prognostic factors of hepatocellular carcinoma patients; single center experience

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