Epidemiology and Survival of Systemic Sclerosis-Systemic Lupus Erythematosus Overlap Syndrome

Abstract

Patients with SSc-SLE are younger at diagnosis, more frequently have PAH, and less frequently have cutaneous manifestations of SSc. They should be monitored for ILD, renal crisis, and digital ulcers.

Successful pembrolizumab treatment in a patient with metastatic urothelial carcinoma and underlying overlap syndrome involving systemic sclerosis and systemic lupus erythematosus

“…5 SSc-SLE overlap syndrome patients are typically female, Asian, tend to be younger than pure SSc patients at diagnosis, and more frequently have pulmonary fibrosis than those with pure SSc. 6 Throughout the course of pembrolizumab treatment, our case did not develop any skin lesions, renal crises, or interstitial lung disease.…”

Characterizing Disease Manifestations and Treatment Patterns Among Adults with Systemic Sclerosis: A Retrospective Analysis of a US Healthcare Claims Population

“…Although antibiotics were the most common treatment received, it was unclear, because of the claims nature of the study, whether they were prescribed to treat infection or bacterial overgrowth. It is known that patients with SSc can have overlap with other diseases, as shown in a recent study reporting a prevalence of 6.8% for overlap with SLE [28], and some patients in this analysis could have had mixed connective tissue disease without a full SSc diagnosis whereas others could have had true overlap syndrome. This could explain hydroxychloroquine being the most commonly initiated IMT among patients with SSc manifestations.…”

Scleroderma-associated thrombotic microangiopathy in overlap syndrome of systemic sclerosis and systemic lupus erythematosus

“…There were no significant differences in the incidences of SRC, interstitial lung disease, and digital ulcers. [ 4 ] According to the Classification Criteria for SSc 2013 ACR/EULAR (total score >9), this patient was definitively diagnosed with a total score of 12 (sclerodactyly of the fingers: 4, fingertip pitting scars: 3, pulmonary arterial hypertension and/or interstitial lung disease: 2 and Raynaud phenomenon: 3). [ 7 ] Meanwhile, based on positivity for ANA and anti-Sm antibodies, a mild decrease in C3, and kidney injury, SLE was also diagnosed, along with histologic lesions typical of LN V observed on renal biopsy.…”

“…Approximately 6.8% to 14.7% of SSc patients have overlapping systemic lupus erythematosus (SLE), called SSc-SLE overlap syndrome. [ 1 , 4 , 5 ] We report a rare case of severe SSc-SLE overlap syndrome combined with SSc-TMA and multiple organ injury in an elderly male.…”