Epidemiology and survival outcomes of sinonasal verrucous carcinoma in the United States

Alonso, José Eugenio Lozano; Han, Albert Y; Kuan, Edward C.; Suh, Jeffrey D.; John, Maie A. St.

doi:10.1002/lary.26790

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…13,[33][34][35] Indeed, HNVC characteristically has a markedly limited propensity for regional or distant metastasis, and enlarged cervical lymph nodes on physical examination are almost always reactive in nature. 13,34,36,37 Metastatic spread of HNVC remains especially uncommon as evidenced by a review of 101 patients with oral cavity VC treated surgically that reported no cases with adverse pathological features such as perineural invasion (PNI) and lymphovascular invasion (LVI). 18 Survival is thus favorable; the 5-year OS in our cohort was 71% which aligns well with existing literature.…”

Section: Discussionmentioning

confidence: 99%

“…The local confinement of HNVC and its relatively benign histopathologic features, such as minimal cytological atypia and an intact basement membrane contribute to its late or potentially absent metastatic potential 13,33‐35 . Indeed, HNVC characteristically has a markedly limited propensity for regional or distant metastasis, and enlarged cervical lymph nodes on physical examination are almost always reactive in nature 13,34,36,37 . Metastatic spread of HNVC remains especially uncommon as evidenced by a review of 101 patients with oral cavity VC treated surgically that reported no cases with adverse pathological features such as perineural invasion (PNI) and lymphovascular invasion (LVI) 18 .…”

Section: Discussionmentioning

confidence: 99%

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Elective Neck Dissection for cT1‐4 N0M0 Head and Neck Verrucous Carcinoma

Patel

Vedula

Haleem

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveTo investigate the survival benefit of elective neck dissection (END) over neck observation in cT1‐4 N0M0 head and neck verrucous carcinoma (HNVC).Study DesignRetrospective cohort study.SettingThe 2006 to 2017 National Cancer Database.MethodsPatients with surgically resected cT1‐4 N0M0 HNVC were selected. Linear, binary logistic, Kaplan‐Meier, and Cox proportional hazards regression models were utilized.ResultsOf 1015 patients satisfying inclusion criteria, 223 (22.0%) underwent END. The majority of patients were male (55.4%) and white (91.0%) with disease of the oral cavity (67.6%) classified as low grade (90.0%) and cT1‐2 (81.8%). The minority of ENDs (4.0%) detected occult nodal metastases. The rate of END increased from 2006 to 2017 for both cT1‐2 (16.3% vs 22.0%, p = .126, R2 = 0.405) and cT3‐4 (41.7% vs 70.0%, p = .424, R2 = 0.232) disease but these trends were not statistically significant. Independent predictors of undergoing END included treatment at an academic facility (adjusted odds ratio [aOR]: 1.75, 95% confidence interval [CI]: 1.19‐2.55), cT3‐4 disease (aOR: 3.31, 95% CI: 2.16‐5.07), and tumor diameter (aOR: 1.09, 95% CI: 1.01‐1.19) (p < 0.05). The 5‐year overall survival (OS) of patients treated with and without END was 71.3% and 70.6%, respectively (p = .661). END did not significantly reduce the 5‐year hazard of death (adjusted hazard ratio: 1.25, 95% CI: 0.91‐1.71, p = .172). END did not significantly improve 5‐year OS in univariate and multivariate analyses stratified by several patient, facility, tumor, and treatment characteristics.ConclusionEND does not confer an appreciable survival benefit in HNVC, even after stratifying univariate and multivariate analyses by several patient, facility, tumor, and treatment characteristics.Level of EvidenceLevel 4.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Elective Neck Dissection for cT1‐4 N0M0 Head and Neck Verrucous Carcinoma

Patel

Vedula

Haleem

et al. 2023

Otolaryngol.--head neck surg.

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“… 3 Other reported locations in the head and neck region affected by verrucous carcinoma are nasal cavity, paranasal sinuses, nasopharynx, oesophagus and temporal bone. 12 , 13 , 14 Verrucous carcinoma on the skin and mucosa of the anogenital region and extremities are described in the literature as well. 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

Oral verrucous carcinoma: a diagnostic and therapeutic challenge

Kristofelc¹,

Zidar

Strojan

2023

Radiology and Oncology

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Background Verrucous carcinoma is a low-grade variant of squamous cell carcinoma with specific morphologic, cytokinetic and clinical features. Despite low mitotic activity and slow growth, it can infiltrate adjacent tissues in advanced stages but does not metastasize. The most frequently affected site is the oral cavity. The following article provides latest updates in the etiology, clinical presentation, diagnostics and treatment options in oral verrucous carcinoma and discusses the existing dilemmas linked to this unique malignancy. Conclusions Oral verrucous carcinoma must be differentiated from conventional squamous cell carcinoma due to its less aggressive behaviour with a more favourable prognosis. Close communication between clinician and pathologist is mandatory for making a correct diagnosis. Primary surgery with negative surgical margins seems to be the most successful treatment. However, management recommendations are not uniform since they are mostly based on case reports and small retrospective case series. Prospective and pooled multi-institutional studies are therefore needed.

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Head and neck verrucous carcinoma

Wang

Huang

2020

Medicine

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Verrucous carcinoma is a rare variant of squamous cell carcinoma. The oral cavity, genitals, larynx, esophagus, and skin are usually affected, and the head and neck regions are the most affected areas. Few studies reported about head and neck verrucous carcinoma (VC) in the literature. Therefore, we conducted an extensive population-based study about the VCs to use population-based data to further investigate the incidence, treatment, and survival of head and neck verrucous carcinoma. Patients from Surveillance, Epidemiology, and End Results database (SEER) between 1973 and 2015 were brought into our study. The data of VCs and other head and neck malignancies (OHNMs) patients were extracted for analysis. We compared characteristics of patients with VC with those of patients with OHNMs. Results were obtained for 2039 cases of VC and 394,739 cases of OHNM. Compared to patients with OHNM, patients with VC were more often female (36.6% vs 31.1%; P < .001), younger (median age 62 vs 67 years; P < .001), and had a smaller tumor size (P < .001). VC cases were of lower histological grade and SEER stage (P < .001). The incidence of VC was 0.075 per 100,000 and decreased over time (annual change −1.855%, P < .001), whereas the incidence of OHNM showed no change. The primary treatment method for VC was surgery, with other treatments showing no significant therapeutic effect. VC is rare, with a decreasing incident trend. The outcome is better compared with OHNM patients. Surgery could significantly improve VC patients’ prognosis.

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Epidemiology and survival outcomes of sinonasal verrucous carcinoma in the United States

Abstract: 4. Laryngoscope, 128:651-656, 2017.

Cited by 4 publications

References 31 publications

Elective Neck Dissection for cT1‐4 N0M0 Head and Neck Verrucous Carcinoma

Elective Neck Dissection for cT1‐4 N0M0 Head and Neck Verrucous Carcinoma

Oral verrucous carcinoma: a diagnostic and therapeutic challenge

Head and neck verrucous carcinoma

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