Epidemiology and treatment of adenoid cystic carcinoma of the minor salivary glands: A meta-analytic study

Martínez-Rodríguez, Natalia; Leco-Berrocal, Isabel; Rubio-Alonso, Luis; Arias-Irimia, Oscar; Martínez-González, José-Maria

doi:10.4317/medoral.17200

Cited by 39 publications

(26 citation statements)

References 24 publications

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“…Histologically they have a basaloid epithelium clustered in nests in a hyaline stroma. ACC can be categorized into three growth patterns, cribriform, tubular, and solid patterns [48]. The most common histologic subtype is the cribriform type (44%), characterized by a "Swiss cheese" pattern of vacuolated areas.…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

Current Thinking on Malignant Salivary Gland Neoplasms

Arrangoiz¹

2013

JCTR

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Abstract:Malignant salivary gland neoplasms are rare, representing approximately 3% to 7% of all head and neck cancers. Contrasting from the more common mucosal head and neck cancers, which, in general, are ascribed to excessive tobacco, alcohol use, and more recently to viral infection, specific carcinogenic factors for malignant salivary gland growths have not been as clearly identified. Histologically, they represent a heterogeneous group of tumors. Forty histologic types of epithelial tumors of the salivary glands have been reported; some are exceedingly rare and may be the topic of only a few case reports. Salivary tumors can arise in the major salivary glands or in one of the minor salivary glands (predominantly mucus secreting glands), which are distributed throughout the upper aerodigestive. Most patients who develop malignant salivary gland tumors are in the sixth or seventh decade of life. FNA should be considered as part of the diagnostic evaluation but due to its varying sensitivities and specificities imaging modalities such as ultrasound, CT scans, and MRI should also be used as diagnostic adjuncts. Surgery is the primary modality for management of these tumors, nontraditional surgical approaches and instrumentation, as well as facial nerve monitoring, can be selectively utilized to try and decrease the morbidity associated with these surgical procedures. Adjuvant treatment is primarily achieved with radiation therapy. Chemotherapy continues to have a palliative role in the management of salivary gland tumors; however, research in this field is trying to identify a therapeutic role for chemotherapy in order to improve overall survival.

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Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

Current Thinking on Malignant Salivary Gland Neoplasms

Arrangoiz¹

2013

JCTR

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“…Since majority of the patients in this study underwent RT we were unable to evaluate the relationship between OS, recurrence and RT. The role of chemotherapy for adenoid cystic carcinoma is still controversial [24]. In conclusion ACC is relatively rare and it may result in recurrence even many years post-diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Review and Survival Characteristics of Adenoid Cystic Carcinoma

Binesh

Akhavan

Masumi

et al. 2014

Indian J Otolaryngol Head Neck Surg

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To study the clinical characters, the outcomes of treatments and the factors affecting treatment results of adenoid cystic carcinomas at Shahid Sadoughi Hospital and Shahid Ramazanzadeh radiotherapy center, Yazd, Iran. The clinical data of 31 patients with adenoid cystic carcinoma of any anatomic site diagnosed over an 8 year period (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012), were investigated retrospectively. Data regarding patients' characteristics, pathological features and follow-up were obtained from patients records. Survival rate, local recurrence and distant metastasis were analyzed using Kaplan-Meier method. Prognosis factors were analyzed by Log-rank test and Cox regression. The study included31 patients with adenoid cystic carcinoma. The mean age at presentation was 50.2 ± 24.8 years. There were 11 (35.5 %) males and 20 (64.5 %) females with a female predilection (M:F = 0.55:1). Parotid gland was the most common site (8/31, 25.7 %) followed by submandibular gland (7/31, 22.6 %). Perineural invasion was detected in 67.7 % of the cases. Positive surgical status was reported in 48.4 % of the specimens. Metastasis was detected in 25.8 % of the patients and the most common site of distant metastasis was lung. Overall survival rates at 2, 5, and 7 years were 95, 75, and 57 % respectively. Margin status showed significant effect on survival (P value = 0.01). Positive surgical margin is an important factor affecting the prognosis of the patients with adenoid cystic carcinoma. Surgery with negative surgical margin is the first choice of treatment for the patients with adenoid cystic carcinoma. Our findings show that the prognosis of patients with adenoid cystic carcinoma in our center is fair.

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“…40 The solid pattern of ACC is believed to be the most aggressive form with poor prognosis. 39 Solid ACC is characterized histopathologically by tumor nests or islands completely filled with basaloid cells without cystic spaces. multicystic ameloblastoma (SMA) with only 11 cases reported in the literature so far.…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

An Insight into the Histopathology of Oral Neoplasms with Basaloid Morphology and a Working Classification

Bajpai

Pardhe

2017

PJP

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Basal cell tumors (BCT) are tumors usually derived from pluripotential stem cell compartments of the basal layer of epidermis and/or oral epithelium. BCTs are infrequent entities in the oral cavity and are not discussed separately in general and oral pathology. A literature review did not reveal any classification of tumors with basaloid morphology. This paper is an attempt to categorize the oral neoplasms with basaloid morphology and discuss their differential diagnoses in detail. A review of the literature was carried out to rule out the frequency of different oral BCTs reported in the literature. Additionally, a simple working classification of oral BCTS has been proposed. We hope that this classification will be helpful for oral and general pathologists and students.

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Epidemiology and treatment of adenoid cystic carcinoma of the minor salivary glands: A meta-analytic study

Cited by 39 publications

References 24 publications

Current Thinking on Malignant Salivary Gland Neoplasms

Current Thinking on Malignant Salivary Gland Neoplasms

Clinicopathological Review and Survival Characteristics of Adenoid Cystic Carcinoma

An Insight into the Histopathology of Oral Neoplasms with Basaloid Morphology and a Working Classification

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