Epidemiology and treatment-related concerns of gout and hyperuricemia in Korean

Abstract

Gout is the most common form of inflammatory arthritis that affects mainly middle-aged men, and there is clear evidence of an association between hyperuricemia and the risk for gout. Increasing prevalence of gout and hyperuricemia has been reported in many countries. The prevalence of gout and hyperuricemia are constantly increasing in Korea with the patients at risk for developing a variety of comorbidities. Although there have been studies on the association between gout or serum uric acid level and several neurodegenerative diseases, cancer, and cardiovascular mortality, the causal relationship between gout and these comorbidities are still unclear. The associations of substantial economic burden with hyperuricemia, gout attack, and suboptimal treatment are well known. Gout is a disease that requires lifelong management including lifestyle modification. However, gout is poorly managed worldwide although effective urate-lowering drugs exist. In this review, we addressed epidemiological studies and treatment-related problems in the Korean population with gout or hyperuricemia to obtain the best clinical outcomes and reduce their medical burden.

Association Between Remnant Cholesterol and Risk of Hyperuricemia: A Cross-Sectional Study

“…It is not only an early and primary cause of gout, but modern research has also identified it as a significant risk factor for diseases such as diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases, as well as an increased risk of mortality 2 3 4 5 6 . In recent years, the incidence of hyperuricemia has surged globally, imposing substantial medical and economic burdens worldwide 2 7 .…”

Effects of Smilax China L. extracts on Hyperuricemia chicken model via inhibiting xanthine oxidase activity

“…Based on the survey findings, the overall prevalence of HUA in Korea surged from 5.1% to 11.4% between 2004 and 2016. In parallel, Japan saw an increase in total prevalence from 10.8% to 13.4% spanning from 2008 to 2017 ( Ahn, 2023 ). The rising incidence of HUA is now identified as a burgeoning public health issue on a global scale.…”