Epidemiology, clinical features, and outcomes of strongyloidiasis in Taiwan from 1988 to 2020: A case series and literature review

Chen, Yung-An; Hsu, Heng-Ming; Wang, Hsuan; Lan, Hung-Hsue; Huang, Sung‐Hsi; Hung, Chien‐Ching; Su, Kang‐Yi

doi:10.1016/j.jmii.2022.06.007

Cited by 2 publications

(2 citation statements)

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“…Reported symptoms associated with severe lung involvement included dyspnea, cough, wheezing, chest pain, hoarseness and hemoptysis. In a case series from Taiwan, a Strongyloides -endemic region, respiratory presentation was common, with dyspnea in 47% of patients, cough in 37% and hemoptysis in 4% of patients [19 ▪ ]. Solid organ transplant recipients are at high risk for severe strongyloidiaisis.…”

Section: Strongyloides and Lung Involvementmentioning

confidence: 99%

“…The use of corticosteroids in chronic disease such as chronic obstructive pulmonary disease (COPD) has also been associated with severe strongyloidiasis [24–26]. In a recent case series from Taiwan, COPD or asthma were associated with an increased risk of SHS/disseminated strongyloidiasis [19 ▪ ]. Chronic strongyloidiasis may mimic and be misdiagnosed as asthma or COPD.…”

Section: Strongyloides and Lung Involvementmentioning

confidence: 99%

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Strongyloidiasis-related lung involvement: too much of a bad thing

Barkati

Greenaway

Libman

2023

Current Opinion in Infectious Diseases

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Purpose of reviewStrongyloidiasis is a soil-transmitted helminthiasis, a neglected tropical disease that affects 300–900 million individuals globally. Strongyloides stercoralis is associated with cutaneous, respiratory, and gastrointestinal clinical manifestations. Chronicity is due to an autoinfective cycle, and host immunosuppression can lead to severe and fatal disease. Lung involvement is significant in severe strongyloidiasis, and Strongyloides has a complex association with a number of lung diseases, which will be discussed in this review.Recent findingsThe treatment of chronic lung diseases such as asthma and chronic obstructive pulmonary disease with corticosteroids is an important risk factor for Strongyloides hyperinfection syndrome (SHS)/disseminated strongyloidiasis. The use of corticosteroids in the treatment of coronavirus disease 2019 (COVID-19) and potentially COVID-19-induced eosinopenia are risk factors for severe strongyloidiasis. Recent findings have demonstrated a significant immunomodulatory role of Strongyloides in both latent and active pulmonary tuberculosis associated to an impaired immune response and poor outcomes in active pulmonary tuberculosis.SummaryStrongyloides lung involvement is a common finding in severe infection. Prompt recognition of Strongyloides infection as well as prevention of severe disease by screening or presumptive treatment are important goals in order to improve Strongyloides outcomes in at-risk population.

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Section: Strongyloides and Lung Involvementmentioning

confidence: 99%

Section: Strongyloides and Lung Involvementmentioning

confidence: 99%