Epidemiology, clinical pattern and impact of species-specific molecular diagnosis on management of leishmaniasis in Belgium, 2010–2018: A retrospective study

Vandeputte, Martin; Henten, Saskia van; Griensven, Johan van; Huits, Ralph; Esbroeck, Marjan Van; Auwera, Gert Van der; Cnops, Lieselotte; Bottieau, Emmanuel

doi:10.1016/j.tmaid.2020.101885

Cited by 15 publications

(13 citation statements)

References 26 publications

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“…The immigrants were often established in Spain but had recently travelled to their countries of origin. Infections were acquired to a similar extent in the Old and New World (11 and 9, respectively), unlike in other studies, which usually report a predominance of Old World cases (Bart et al., 2013; Di Muccio et al., 2015; Giavedoni et al., 2015; Pérez‐Ayala et al., 2009; Vandeputte et al., 2020). Patient characteristics in terms of age, origin or destination matched those reported for the immigrant population in Spain and the profile of the Spanish traveller in several studies on imported diseases (Instituto Nacional de Estadística, 2020; Jaén‐Sánchez et al., 2016; Valerio et al., 2005; Zamarrón Fuertes et al., 2010).…”

Section: Discussionmentioning

confidence: 62%

“…Confirmed imported cases represented 39% of the analysed strains from the last decades, which constitutes an important increase, in agreement with other studies in Spain (Giavedoni et al., 2015; Riera et al., 2016). An increasing tendency of imported leishmaniasis has been observed around the world as a result of globalisation, even affecting non‐endemic countries (Bart et al., 2013; Di Muccio et al., 2015; Söbirk et al., 2018; Stark et al., 2008; Vandeputte et al., 2020). According to data from the World Tourism Organization, the number of international tourist arrivals worldwide in the studied period rose from 277 million in 1981 to 1,407 million in 2018 (World Turism Organization, 2020).…”

Section: Discussionmentioning

confidence: 99%

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Autochthonous and imported tegumentary leishmaniasis in Catalonia (Spain): Aetiological evolution in the last four decades and usefulness of different typing approaches based on biochemical, molecular and proteomic markers

Fernández-Arévalo

Ballart

Muñoz-Basagoiti

et al. 2021

Transbounding Emerging Dis

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Leishmaniasis is a transmissible disease caused by Leishmania protozoa. Spain is endemic for both visceral and cutaneous leishmaniasis, the autochthonous aetiological agent being Leishmania infantum. Around the world, the L. donovani complex is associated with visceral symptoms, while any species of the Leishmania or Viannia subgenera affecting human can produce tegumentary forms. In a context of growing numbers of imported cases, associated with globalisation, the aim of this study was to analyse the aetiological evolution of human tegumentary leishmaniasis in a region of Spain (Catalonia). Fifty‐six Leishmania strains, isolated from 1981 to 2018, were analysed using MLEE, gene sequencing (hsp70, rpoIILS, fh and ITS2) and MALDI‐TOF. The utility of these different analytical methods was compared. The results showed an increase in leishmaniasis over the two last decades, particularly imported cases, which represented 39% of all cases studied. Leishmania infantum, L. major, L. tropica, L. braziliensis, L. guyanensis and L. panamensis were identified. The combination of molecular and enzymatic methods allowed the identification of 29 different strain types (A to AC). Strain diversity was higher in L. (Viannia), whilst the different L. major types were relatable with geo‐temporal data. Among the autochthonous cases, type C prevailed throughout the studied period (39%). Minor types generally appeared within a short time interval. While all the techniques provided identical identification at the species complex level, MALDI‐TOF and rpoIILS or fh sequencing would be the most suitable identification tools for clinical practice, and the tandem hsp70‐ITS2 could substitute MLEE in the epidemiological field.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Autochthonous and imported tegumentary leishmaniasis in Catalonia (Spain): Aetiological evolution in the last four decades and usefulness of different typing approaches based on biochemical, molecular and proteomic markers

Fernández-Arévalo

Ballart

Muñoz-Basagoiti

et al. 2021

Transbounding Emerging Dis

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“…As far as we know from literature, this is the first case of complex facial CL successfully treated with IL meglumine antimoniate in monotherapy in Belgium 3 . Although spontaneous resolution can be observed in CL, skin lesions can be very disfiguring.…”

Section: Report Of a Casementioning

confidence: 81%

Intralesional injections of meglumine antimoniate to treat complex facial leishmania infantum acquired in Spain: a case report

Mostmans

Gysel

Nest³

et al. 2022

Acad Dermatol Venereol

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“…Delayed diagnosis has also been observed in other case series. [19][20][21] Diagnostic delay has also been observed in endemic settings such as Spain. 20 Although the numbers are small in our study, it appears that there is a difference in morphology at initial presentation between Old World and New World cutaneous leishmaniasis.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous leishmaniasis in travellers and migrants: a 10-year case series in a Canadian reference centre for tropical diseases

Lemieux

Lagacé

Billick

et al. 2022

cmajo

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Cutaneous and mucosal leishmaniasis are protozoan infections transmitted by the bite of female sandflies. This tropical disease affects 700 000 to 1 million new individuals annually. 1 Close to 20 species of Leishmania, belonging to 2 main subgenera (Leishmania and Viannia), are involved in human leishmaniasis. Cases of cutaneous leishmaniasis mainly occur in the Americas (New World leishmaniasis), as well as in the Mediterranean basin, the Middle East and Central Asia (Old World leishmaniasis).The clinical presentation of cutaneous leishmaniasis depends on various factors, including the acquired species, strains and virulence factors, as well as host characteristics, such as age, gender and immune status. 2,3 The lack of awareness of this disease among physicians in nonendemic countries, as well as varied clinical manifestations, may result in delayed diagnosis. 4

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Epidemiology, clinical pattern and impact of species-specific molecular diagnosis on management of leishmaniasis in Belgium, 2010–2018: A retrospective study

Cited by 15 publications

References 26 publications

Autochthonous and imported tegumentary leishmaniasis in Catalonia (Spain): Aetiological evolution in the last four decades and usefulness of different typing approaches based on biochemical, molecular and proteomic markers

Autochthonous and imported tegumentary leishmaniasis in Catalonia (Spain): Aetiological evolution in the last four decades and usefulness of different typing approaches based on biochemical, molecular and proteomic markers

Intralesional injections of meglumine antimoniate to treat complex facial leishmania infantum acquired in Spain: a case report

Cutaneous leishmaniasis in travellers and migrants: a 10-year case series in a Canadian reference centre for tropical diseases

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