Epidemiology, Clinico-radiological Profile and Management of Hepatocellular Carcinoma in a Tertiary Care Center in Nepal

Deo, Rajeeb Kumar; Chitalkar, Prakash; Malla, Srijan; Kc, Indu; Karki, Binod; Thapa, Rajkumar

doi:10.3126/mjsbh.v20i1.32256

Cited by 3 publications

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“…It is the presence of the signs that constitutes the only diagnostic circumstance. In the present study, these circumstances of cancer diagnosis are dominated by abdominal pain, asthenia and weight loss, confirming the results reported by Somé et al [16] in Burkina Faso and Déo et al [17] in Nepal.…”

Section: Discussionsupporting

confidence: 93%

Profile of people living with cancer followed in the palliative care unit of Parakou, Benin in 2021

ALASSANI¹,

DOVONOU²,

SAKE³

et al. 2023

World J. Adv. Res. Rev.

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Introduction: Cancer is a global public health problem. This study focused on the the profile of people living with cancer in Parakou. Study method: This was a cross-sectional, descriptive and analytical study which enrolled people living with cancer followed in the palliative heath care of the internal medicine unit at the Regional University Health Center of Borgou who had given their consent. The variables of the study were: sociodemographic data, nutritional status, comorbidities, circumstances of cancer screening and their location. Data analysis was performed using Epi Data 3.1 software. Results: The study population consisted of 264 people with cancer. A male predominance was observed with a sex ratio of 2.66. The average age was 47.51 years ±13.20. Alcohol consumption was observed in 15.2%. Arterial hypertension was found in 63.6% of subjects. On the nutritional level, malnutrition and weight loss were observed respectively in 68.2% and 98.1% of patients. Abdominal pain, asthenia and weight loss were the main circumstances for cancer screening and were present in 37.1%, 27.6% and 16.7% of participants respectively. Liver cancer was found in the majority (72%) of the participants. Viral hepatitis B was the most common cause with 98.3% Conclusion: cancer affects young adults and is often detected at an advanced stage. The main site is the liver and infection with the hepatitis B virus is found in most of the cases.

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Section: Discussionsupporting

confidence: 93%

Profile of people living with cancer followed in the palliative care unit of Parakou, Benin in 2021

ALASSANI¹,

DOVONOU²,

SAKE³

et al. 2023

World J. Adv. Res. Rev.

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“…Abnormal physiological effects, unhealthy habits, dietary mix and lifestyle, and other healing factors are ignored, causing hepatitis attacks [ 7 ]. For example, Chen Haiyan found in “Influencing Factors of Creating Healthy Behaviors and Preventive Measures for Secondary Hospitalization of Patients with Diffuse Hepatitis” that the second hospitalized patient had bad habits, living habits, and poor mentality [ 8 ]. Depending on the individual behavior of creating a healthy lifestyle for these patients, radical adherence to treatment may reduce seizures or reduce seizure levels [ 9 ].…”

Section: State-of-the-art Technologymentioning

confidence: 99%

The Application of Focused Care Model in the Management of Hepatitis B Patients in a Tertiary Care Hospital and the Impact on Patients’ Quality of Life

Zhang

Wang

Shan

et al. 2022

Computational and Mathematical Methods in Medicine

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Chronic hepatitis B is one of the common infectious diseases in the world, with a wide epidemic range and strong contagiousness, which is difficult to completely eradicate. From July 2020 to April 2022, 142 patients with hepatitis B who were admitted to tertiary hospitals were selected and randomly divided into 2 cases, with 71 cases per case. The control group adopts a conventional model, and the observation group implements a nursing model based on the control group. The management capacity and quality of life before and after the two groups of care were compared. 94 patients with chronic hepatitis B who were admitted to the hospital from July 2020 to April 2022 were selected, and 47 cases were divided into the control group and observation group according to the admission time. The control group is given a conventional model, and the observation group is given a nursing model on the basis of the control group. Both groups of patients observed anxiety self-assessment scale (SAS), depression self-assessment scale (SDS), short life span scale (SF-36) scores, and treatment conditions before and after the intervention, to explore the application of nursing model in the management of hepatitis B patients in tertiary hospitals and its impact on patient quality of life. Based on study’s precare outcomes, there was no statistically significant difference between the self-administered scale (PIH) score and the quality of life measurement summary scale (QOL-BREF) score ( P > 0.05 ) between the two groups. After one month of care, both groups had lower PIH scores than before care, and QOL-BREF scores were higher than before care ( P < 0.05 ). After one month of treatment, the PIH score of the observation group was significantly reduced, and the QOL-BREF score after one month of treatment was significantly higher than that of the control group ( P < 0.05 ). The SAS and SDS scores in the observation group were lower than those in the control group, and the quality of life scores and treatment compliance were higher than those in the control group, and the difference was statistically significant ( P < 0.05 ). Conclusions. The nursing model can effectively improve the management and quality of life of hepatitis B patients. It also had a significant positive effect on the therapeutic capacity and quality of life of patients with hepatitis B and improved patient compliance behavior and quality of life.

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Assessment of clinico-epidemiological profile of Hepatocellular carcinoma in the last two decades

et al. 2023

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Background Hepatocellular carcinoma represents 85%—90% of primary liver tumors; it represents the 2nd leading cause of cancer-related death all over the world. There is a growing incidence of HCC worldwide and similarly, the incidence of HCC has almost doubled over the last decade in Egypt. Aim of the work To assess clinico-epidemiological character of HCC in the last two decades and to compare between the first and second decade regarding these characters. Patients and methods This retrospective study included 497 HCC patients’ data collected from Clinical Oncology and Nuclear Medicine Department from 1999 to 2019, HCC patients were classified into 1st decade (from 1999 to 2009) and 2nd decade (2010 – 2019). Diagnosis of HCC was based on clinical, laboratory, (AFP), and radiological examinations (The abdominal US and triphasic CT scan). Results The study revealed that the average age of HCC cases was 57 years, the majority of these were males (88%), residents in rural areas (70%), about one-fourth of them, were smokers (26.4%), DM was present in 14% of these while only 7% were hypertension. Thirty presents (30%) of them were represented by ascites and (20%) by hepatic encephalopathy of different grades. The majority of HCC patients (92.2%) have HCV Abs positive. HBS Ag was positive in 2.4% while mixed infection (HCV Abs + ve and HBS Ag + ve) was in 2% of patients only. The median level of AFP was 300 ng/ml. The severity of underlying chronic liver disease was assessed by the Child–Pugh score the mean score was 7.5 (from 6–11) and the MELD score (the mean score was 18.8 (from 6–29). Regarding tumor characteristics, HCC mass was located in the Right lobe of the liver in (63.8%), in the left lobe in (26.6%) and both lobes were affected in 9.6%. A single focal hepatic lesion was detected in about 60% of patients, 3 focal lesions in about 20%, and two focal lesions or multifocal HCC in the remaining percent. The median size of the largest tumor’s diameter was 5 cm by the US and 5.3 cm by the triphasic CT. PVT, vascular invasion, LN, and distant metastasis were detected in (35.6%), (40%), (40%) and (54%) of patients respectively. In less than one-third of HCC cases, the tumors were within Milan criteria (30%). Conclusion The 1st decade showed a significantly higher frequency of patients presented with marked splenomegaly and splenectomy, while the second decade showed a significantly higher frequency in patients who reside in rural areas. Higher frequency of DM, advanced hepatic encephalopathy grade III/ IV, and unfortunately more aggressive tumors with PVT, vascular invasion, LN metastasis, and distant metastasis were detected in the 2nd decade.

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Epidemiology, Clinico-radiological Profile and Management of Hepatocellular Carcinoma in a Tertiary Care Center in Nepal

Cited by 3 publications

References 0 publications

Profile of people living with cancer followed in the palliative care unit of Parakou, Benin in 2021

Profile of people living with cancer followed in the palliative care unit of Parakou, Benin in 2021

The Application of Focused Care Model in the Management of Hepatitis B Patients in a Tertiary Care Hospital and the Impact on Patients’ Quality of Life

Assessment of clinico-epidemiological profile of Hepatocellular carcinoma in the last two decades

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