Epidemiology, etiology and pathogenesis of eosinophilic esophagitis. The latest data

Кайбышева, В. О.; Mikhaleva, Liudmila M.; Никонов, Е. Л.; Shapovalyants, S. G.

doi:10.17116/dokgastro2019802150

Cited by 4 publications

(4 citation statements)

References 200 publications

(251 reference statements)

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“…В этом клиническом случае были применены все Стеноз пищевода у ребенка с эозинофильным эзофагитом: диагностика и положительная динамика на фоне консервативной терапии * Лохматов М. М. 1,2 , Макарова С. Г. 1,3 , Фисенко А. П.…”

Section: резюмеunclassified

“…Также данный цитокин может приводить к гипертрофии гладкомышечных клеток пищевода, способствуя нарушениям его моторной функции. IL-13 вызывает ремоделирование тканей за счет отложений коллагена в стенке пищевода, ангиогенеза, гипертрофии гладкомышечных клеток [2,3].…”

Section: Introductionunclassified

“…В настоящее время большинство исследований свидетельствует о, хотя и медленном, но прогрессирующем течении данного заболевания [1,2,5]. Так, в недавнем мультицентровом исследовании, включавшем 721 пациента (в том числе 117 детей) было показано, что во время естественного течения ЭоЭ происходит прогрессирование воспалительного фенотипа в фибростенотический.…”

Section: Introductionunclassified

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Esophageal stenosis in a child with eosinophilic esophagitis: diagnosis and positive dynamics against the background of conservative therapy

Лохматов

Макарова

Фисенко

et al. 2022

jour

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Introduction. Currently, eosinophilic esophagitis (EoE) is a big and urgent problem for modern pediatrics. Its pathogenesis is associated with the formation of stenoses and strictures of the esophagus during a long course of the disease without treatment, which leads to serious disorders in the nutrition of children. In widespread practice, X-ray contrast examination of the esophagus is used, however, it is also necessary to perform esophagogastroduodenoscopy (EGDS) with taking multiple biopsies with morphological examination to verify the diagnosis. Materials and methods. Boy Y. 12 years, was admitted in March 2021 with complaints of difficulty in swallowing solid food, as well as poor weight gain. From the anamnesis of the disease, it is known that the phenomena of dysphagia were noted from the preschool period. Symptoms have progressed over the past year. EGDS was performed. A biopsy was taken: 6 fragments of the esophagus, 2 fragments from each third. Results. Diagnosed with eosinophilic esophagitis, complicated by esophageal stenosis. Chronic gastritis, Helicobacter pylori-not associated, incomplete remission. Chronic duodenitis, incomplete remission. Protein-energy malnutrition, mild. Appropriate treatment was prescribed. An allergological examination of the child was carried out and recommendations for nutrition were given. Against the background of the therapy, the child’s condition with pronounced positive dynamics - the appetite improved, the phenomena of dysphagia were completely stopped. When the child was re-hospitalized a month later, there was an increase in body weight (900 g) and growth (3 cm). Conclusions. The high efficiency of complex conservative therapy has been shown. The prescribed conservative treatment made it possible to avoid dilatation and bougienage of the esophagus. In this case, all three components of EoE treatment were applied: elimination diet, proton pump inhibitors, and topical corticosteroids. In the future, it is necessary to observe the allergist, taking into account the data obtained on multiple sensitization with a decision on the question of further treatment.

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Section: резюмеunclassified

Section: Introductionunclassified

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Esophageal stenosis in a child with eosinophilic esophagitis: diagnosis and positive dynamics against the background of conservative therapy

Лохматов

Макарова

Фисенко

et al. 2022

jour

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“…Eosinophilic esophagitis (EoE) is an immune-mediated disease of the esophagus that manifests with dysphagia and is characterized by the predominantly eosinophilic infiltration of the esophageal mucosa (>15 eosinophils in high power field, eos/hpf) [1][2][3][4][5]. EoE is a chronic disease arising in predisposed individuals that often harbor one or several atopic conditions: bronchial asthma, atopic rhinitis, atopic dermatitis, eczema, etc.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Severity and the Remission Criteria in Eosinophilic Esophagitis

Maslenkina,

Mikhaleva,

Mikhalev

et al. 2023

Biomedicines

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Eosinophilic esophagitis (EoE) is an immune-mediated disease that manifests with dysphagia and is characterized by the predominantly eosinophilic infiltration of the esophageal mucosa. Several instruments have been developed to assess the symptoms of EoE: the Daily Symptom Questionnaire (DSQ), EoE Activity Index (EEsAI), Pediatric EoE Symptom Severity (PEESSv2), etc. The use of the EREFS is a gold standard for endoscopic diagnosis. The EoE histologic scoring system (EoEHSS) was elaborated for the assessment of histological features in EoE. However, the remission criteria are not clearly defined and vary greatly in different studies. Gastroenterologists establish the severity of EoE mainly based on endoscopic findings. At the same time, EoE requires a multidisciplinary approach. The recently developed Index of Severity of Eosinophilic Esophagitis (I-SEE) that is built on symptoms, endoscopic findings, and histological features is promising.

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Early IgE production is associated with accumulation of CD11b+ classical dendritic cells and CD11b+CD11c- macrophages in subcutaneous adipose tissue

et al. 2022

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In view of increased incidence of IgE-mediated diseases in Russia and worldwide, the efforts of various research groups are focused on studying the mechanisms that trigger the process of switching B-lymphocytes to IgE synthesis upon human exposure to harmless allergens, including the role of various antigen-presenting cells (APCs) in this process. However, the role of distinct APCs upon long-term penetration of low antigen doses via the tissue barriers, is yet poorly understood, as well as specific features of these events upon entrance of the antigen through the subcutaneous adipose tissue which contains tissueassociated lymphoid clusters (TALC).The aim of this work was to determine the relationship between the local accumulation of various APCs in the subcutaneous adipose tissue and development of early IgE production in a clinically relevant experimental model of allergy with long-term administration of low allergen doses. In this experimental model, specific IgE synthesis is induced, with minimal concomitant IgG production, thus mimicking the situation observed in patients with clinically sound allergies. BALB/c mice were immunized for 4 weeks subcutaneously in the withers area or intraperitoneally with low (100 ng) or high (10 μg) doses of the model allergen (ovalbumin). Blood samples were taken weekly from mice for ELISA testing, to determine the production of specific antibodies. Provocation tests were performed with high dose of the allergen, and adipose tissue samples were taken from the site of antigen injection for flow cytometric assays, in order to evaluate the contents of various APC subpopulations. Specific IgE production was induced mainly by subcutaneous injection of the antigen at low doses (100 ng) into the area of withers. When using this experimental regimen, we observed accumulation of classical CD11b+ cells in adipose tissue at the withers site, but not in the peritoneal adipose tissue, in absence of CD11b- classical, inflammatory or plasmacytoid, dendritic cells. These findings coincided in time with increased production of specific IgE on days +14 to +21. Accumulation of CD11b+CD11c- macrophages and their CD206+ M2 subpopulations at early terms (days +7 and +21) was also observed only after subcutaneous injection of the antigen into the withers area. The high-dose antigen injection (10 μg) which mediated IgG1 production to greater extent than production of IgE, led to earlier accumulation of CD11b+ classical dendritic cells (on day 7th), and to the absence of macrophage accumulation at later stages (day 21th). Thus, the early start of specific IgE production upon low-dose injection of the antigen into the subcutaneous adipose tissue may be associated with its presentation by CD11b+ classical dendritic cells in the presence of CD11b+CD11c- macrophages.

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Epidemiology, etiology and pathogenesis of eosinophilic esophagitis. The latest data

Cited by 4 publications

References 200 publications

Esophageal stenosis in a child with eosinophilic esophagitis: diagnosis and positive dynamics against the background of conservative therapy

Esophageal stenosis in a child with eosinophilic esophagitis: diagnosis and positive dynamics against the background of conservative therapy

Assessment of the Severity and the Remission Criteria in Eosinophilic Esophagitis

Early IgE production is associated with accumulation of CD11b+ classical dendritic cells and CD11b+CD11c- macrophages in subcutaneous adipose tissue

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