Epidemiology, etiology, and treatment of chronic leg ulcer: Experience with sixty patients

Rahman, GA; Adigun, IA; Fadeyi, Abayomi

doi:10.4103/1596-3519.62615

Cited by 56 publications

(49 citation statements)

References 8 publications

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“…2 The prevalence of vascular ulcers in the US is estimated at 500,000 to 600,000 which increases with age. 3 A study in the UK showed wound prevalence of 3.55 per 1000 population. 4 The majority of wounds were surgical/trauma (48%), leg/foot (28%) and pressure ulcers (21%).…”

Section: Introductionmentioning

confidence: 99%

Vacuum assisted wound healing: can it prove to be cost- effective?

Samant

Sarang

2018

Int Surg J

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Background: In search for a faster and effective method Negative pressure wound therapy (NPWT) also known as Vacuum assisted wound closure (VAC) has emerged to be a promising technology over the years. This study was carried out to determine the clinical efficacy and cost effectiveness of Vacuum assisted closure (VAC) therapy compared to conventional wound therapy.Methods: A prospective randomised study using VAC was performed on cases with chronic non healing wounds using a low cost negative pressure therapy unit. The negative pressure used in the vacuum assisted closure of the wounds was provided by the wall mounted centralised suction apparatus which provided a constant average pressure of 125 mm of Hg (range being 110-200 mm Hg).Results: The rate of wound healing which was exhibited by reduction in size of the wound by more than 1 cm at the end of the first 5 days was higher in the cases (82%) as compared to the control (18%) group. By end of 15 days size reduction of >3 cm was seen almost 85% of the patients treated with NPWT. The total cost incurred in the first group undergoing VAC for a period of 15 days per patient was Rs.750 ($11.16) as against the second group undergoing conventional wound dressing which was Rs.700 ($10.41) for the same period per patient. The cost- benefit analysis of the two groups statistically revealed a p value of <0.05 under 95% confidence limits, thus proving vacuum assisted closure, though slightly expensive than the conventional dressing, to be a better and cost effective modality, taking into consideration the faster wound healing rates.Conclusions: In this study NPWT appeared to exhibit better wound healing and is thus a promising alternative to the conventional management and has a potential to be replicable across many hospitals with financial constraints in the low and middle income countries.

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Section: Introductionmentioning

confidence: 99%

Vacuum assisted wound healing: can it prove to be cost- effective?

Samant

Sarang

2018

Int Surg J

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“…Constructive remodeling can be performed using such natural ECM scaffolds and vegetal/animal stem cells since, the cells can be delivered to the site of infraction and once delivered the cells help wound dressing process. The development of niche mimicking biomaterials and hybrid biomaterial can further advance directed differentiation without specific induction [5] [6]. .…”

Section: Introductionmentioning

confidence: 99%

Special Nanoskin-ACT-Biological Membranes from Deep Wounds

Mualla¹,

Nabooda²,

Salman³

et al. 2018

JBNB

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Bacterial cellulose (BC) is established as a newest biomaterial, and it can be used for medical and odontology applications. In addition, it has called attention for uses such as membrane for wound care and tissue engineering. In this work, the bacterial cellulose fermentation process is modified by the addition of natural materials before the bacteria are inoculated. In vivo behavior using natural ECM for regenerative medicine is presented and completed wound healing process is 3 months.

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“…According to the literature, about 0.5% of the adult population in the western countries still suffers from this pathology, and there is no favorable dynamics. Blood supply disorders are among prevailing reasons for the leg ulcers 1 . Martorell's syndrome (MS)(also known as a hypertensive ischemic leg ulcer, or hypertonic lower leg ulcers), firstly described in 1945, is a rare disease associated with progressive extremity ulcers.…”

Section: Introductionmentioning

confidence: 99%

Hypertensive ulcer of lower extremity (Martorell's syndrome): clinical case with the treatment improvement

Igor

Vasyl

Andrii

et al. 2017

Bangladesh J Med Sci

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Introduction. Martorell's syndrome (MS) is a rare disease associated with chronic progressive hypertension which complicates ulcer defects on the extremities. It requests individual approach to treatment with antihypertensive medications, which help to reduce pathogenesis of the ulceration development. Therefore the aim of this study was to find new treatment methods of this disease. Case presentation. A 83-year-old female Ukrainian patient presented with an ulcer on the right calf, which was extremely painful at night. After all examination it was diagnosed: stage 2 hypertension, high risk, Martorell's syndrome, right lower limb trophic ulcer of the hypertonic genesis. For the treatment of MS we used the combination therapy, which included tissue suturing on the whole area of the ulcer and auto-dermoplasty with PRP applications. After that was noted intense regenerative processes and recovery of the patient. Conclusions. Chronic leg ulcers are rarely caused by Martorell's syndrome. It requires the complex approach to the treatment under obligatory antihypertensive therapy with its further prolongation. The complex therapy improved by the platelet-rich auto plasma activates the therapeutic effect, which results in intensive healing of the ulcer and faster improvement in pain relief. The platelet-rich auto plasma may become an economic method of treatment the ulcers of any genesis.

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Epidemiology, etiology, and treatment of chronic leg ulcer: Experience with sixty patients

Abstract: Most patients benefited from debridement with or without split thickness skin graft or flap.

Cited by 56 publications

References 8 publications

Vacuum assisted wound healing: can it prove to be cost- effective?

Vacuum assisted wound healing: can it prove to be cost- effective?

Special Nanoskin-ACT-Biological Membranes from Deep Wounds

Hypertensive ulcer of lower extremity (Martorell's syndrome): clinical case with the treatment improvement

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