Epidemiology—Found in Translation

Spitz, Margaret R.; Caporaso, Neil E.; Freedman, Andrew

doi:10.1158/2159-8274.cd-11-0042

Cited by 2 publications

(1 citation statement)

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“…Such hypotheses can be evaluated in existing observational cohort studies with long-term follow-up for a large number of participants and many possible cancer outcomes, eventually moving to clinical trials. (10,11)…”

Section: Conceptual Modelmentioning

confidence: 99%

Opportunities for Translational Epidemiology: The Important Role of Observational Studies to Advance Precision Oncology

Marrone

Schilsky

Liu

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Within current oncology practice several genomic applications are being use to inform treatment decisions with molecularly targeted therapies in breast, lung, colorectal, melanoma and other cancers. This commentary introduces a conceptual framework connecting the full spectrum of biomedical research disciplines, including fundamental laboratory research, clinical trials, and observational studies in the translation of genomic applications into clinical practice. The conceptual framework illustrates the contribution that well-designed observational epidemiological studies provide to the successful translation of these applications, and characterizes the role observational epidemiology plays in driving the dynamic and iterative bench-to-bedside, and bedside-to-bench translation continuum. We also discuss how the principles of this conceptual model, emphasizing integration of multidisciplinary research, can be applied to the evolving paradigm in “precision oncology” focusing on multiplex tumor sequencing, and we identify opportunities for observational studies to contribute to the successful and efficient translation of this paradigm.

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Section: Conceptual Modelmentioning

confidence: 99%