Epidemiology, management and survival outcomes of primary cutaneous melanoma: a ten-year overview

Aubuchon, M M F; Bolt, Lars J.J.; Janssen‐Heijnen, M.L.G.; Verleisdonk-Bolhaar, S T H P; Marion, A van; Berlo, C.L.H. van

doi:10.1080/00015458.2016.1242214

Cited by 30 publications

(26 citation statements)

References 26 publications

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“…Further functional and mechanistic characterization demonstrated that SLNCR1 increases melanoma invasion by transcriptionally upregulating matrix metalloproteinase 9 (MMP9) in cooperation with the brain‐specific homeobox protein 3a (Brn3a) and the androgen receptor (AR) . This study may partially why males have higher incidence of melanoma metastases and exhibit an overall lower survival …”

Section: Deregulated Lncrnas In Melanomamentioning

confidence: 96%

Long non‐coding RNAs in melanoma

Zheng

Tse

et al. 2018

Cell Proliferation

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Melanoma is the most lethal cutaneous cancer with a highly aggressive and metastatic phenotype. While recent genetic and epigenetic studies have shed new insights into the mechanism of melanoma development, the involvement of regulatory non-coding RNAs remain unclear. Long non-coding RNAs (lncRNAs) are a group of endogenous non-protein-coding RNAs with the capacity to regulate gene expression at multiple levels. Recent evidences have shown that lncRNAs can regulate many cellular processes, such as cell proliferation, differentiation, migration and invasion. In the melanoma, deregulation of a number of lncRNAs, such as HOTAIR, MALAT1, BANCR, ANRIL, SPRY-IT1 and SAMMSON, have been reported. Our review summarizes the functional role of lncRNAs in melanoma and their potential clinical application for diagnosis, prognostication and treatment.

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Section: Deregulated Lncrnas In Melanomamentioning

confidence: 96%

Long non‐coding RNAs in melanoma

Zheng

Tse

et al. 2018

Cell Proliferation

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“…Cutaneous melanoma is a very aggressive cancer whose incidence has rapidly increased worldwide. The prognosis is generally poor given the propensity of melanoma cells to spread to distant sites while evading immune system control [ 1 ]. The relevant events that favour the immune escape of melanoma cells include the variable antigenic profile of the tumor cells, the enrolment of suppressor cells, the release of soluble factors within the microenvironment and the propagation of signals driven by melanoma microRNAs (miRNAs) [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Exosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity

et al. 2018

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Exosomes (Exo) are small vesicles produced by melanoma cells and the accessory cells of the tumor microenvironment. They emerge via both classical and direct pathways and actively participate in tumor colonisation of distant tissues. The proteins, nucleic acids, cytokines and growth factors engulfed by Exo are transferred to recipient cells, where they drive numerous functions required for the tumor escape from immune system control and tumor progression. By positively or negatively modulating immune cell properties, Exo provoke immune suppression and, in turn, defective dendritic cell (DC) functions. Together, these effects limit the cytotoxicity of T-cells and expand both T-regulatory and myeloid-derived suppressor populations. They also hinder perforin and granzyme production by natural killer cells. Finally, Exo also control the organotropism of melanoma cells. The distinct phenotypic properties of Exo can be exploited both for diagnostic purposes and in the early identification of melanoma patients likely to respond to immunotherapy. The potential therapeutic application of Exo derived from DCs has been demonstrated in vaccination trials, which showed an increase in anti-melanoma activity with respect to circulating tumor cells. However, additional studies are required before Exo can be effectively used in diagnostic and therapeutic applications in melanoma.

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“…In patients with a local primary melanoma, metastasis is an important prognostic factor. For primary melanomas, histopathological staging is usually a prognostic indicator (de Giorgi et al, ; Hayes et al, ; Tsao et al, ; Aubuchon et al, ; Hwang et al, ). However, cell transmission often occurs in melanoma tumors initially classified histologically as a non‐metastatic primary tumor.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐378 regulates epithelial–mesenchymal transition and metastasis of melanoma by inhibiting FOXN3 expression through the Wnt/β‐catenin pathway

Sun

et al. 2019

Cell Biology International

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MicroRNAs (miRNAs) participate in the development and progression of melanoma. However, while dysregulation of microRNA-378 (miR-378) has been seen in various cancer types, its clinical importance and function in melanoma is poorly elucidated. In this work, miR-378 expression in melanoma and in adjacent non-cancerous tissue was evaluated with quantitative real time polymerase chain reaction (qRT-PCR). A series of assays (wound healing, Transwell and nude mouse subcutaneous tumor model) were used to investigate the implications of abnormal miR-378 regulation on melanoma cell migration and invasion in vitro, and on tumorigenicity in vivo. Prediction and conformation of the miR-378 target gene was undertaken using bioinformatic analysis and luciferase reporter system. Expression of miR-378 was often increased in melanoma, and shown to potentiate its migration, invasion and tumorigenicity. miR-378 acted, at least partially, through inhibition of the potential target FOXN3 and via Wnt/β-catenin pathway activation. The findings indicate that miR-378 triggers melanoma development and progression. This microRNA could be a novel diagnostic and prognostic biological marker, and provide utility for targeted treatment of melanoma.

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Epidemiology, management and survival outcomes of primary cutaneous melanoma: a ten-year overview

Cited by 30 publications

References 26 publications

Long non‐coding RNAs in melanoma

Long non‐coding RNAs in melanoma

Exosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity

MicroRNA‐378 regulates epithelial–mesenchymal transition and metastasis of melanoma by inhibiting FOXN3 expression through the Wnt/β‐catenin pathway

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