Epidemiology: Mathematical modelling of pseudorabies virus (Syn. Aujeszky's disease virus) outbreaks aids eradication programmes: A review

Nes, A. van

doi:10.1080/01652176.2001.9695070

Cited by 9 publications

(7 citation statements)

References 31 publications

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“…For this reason, management procedures could be more relevant in infectious disease control for less contagious diseases. Our conclusion is based on pseudorabies transmission inside each farm, and it cannot be extrapolated to pseudorabies transmission between herds where other factors, such as the herd size, are relevant [13]. Anyway, this conclusion needs to be checked against other pig diseases using modelling approaches.…”

Section: Discussionmentioning

confidence: 95%

“…Mathematical models can help us to understand the factors influencing the epidemiology of infectious diseases and to design more efficient control strategies. The Susceptible-Infectious-Recovered (SIR) model was initially used for modelling pseudorabies epidemiology at farm and regional levels [13]. The SIR model is a stochastic and equation-based model where animals are sorted into population groups where any animal has the same chance of catching the pathogen from an infected animal due to the homogeneous mixing in the population.…”

Section: Discussionmentioning

confidence: 99%

“…The chances of an individual becoming infected decrease as the density of vaccinated animals in a population increases [12]. In pig medicine, the prevalence of Aujeszky's disease has been reduced in many countries by vaccination strategies combined with the elimination of infected animals, and the available vaccines are well-known and highly efficacious [11,13].…”

Section: Introductionmentioning

confidence: 99%

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Vaccination Is a Suitable Tool in the Control of Aujeszky’s Disease Outbreaks in Pigs Using a Population Dynamics P Systems Model

Colomer

Margalida

Fraile

2020

Animals

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Aujeszky’s disease is one of the main pig viral diseases and results in considerable economic losses in the pork production industry. The disease can be controlled using preventive measures such as improved stock management and vaccination throughout the pig-rearing period. We developed a stochastic model based on Population Dynamics P systems (PDP) models for a standard pig production system to differentiate between the effects of pig farm management regimes and vaccination strategies on the control of Aujeszky’s disease under several different epidemiological scenarios. Our results suggest that after confirming the diagnosis, early vaccination of most of the population (>75%) is critical to decrease the spread of the virus and minimize its impact on pig productivity. The direct economic cost of an outbreak of Aujeszky’s disease can be extremely high on a previously uninfected farm (from 352–792 Euros/sow/year) and highlights the positive benefits of investing in vaccination measures to control infections. We demonstrate the usefulness of computational models as tools in the evaluation of preventive medicine programs aimed at limiting the impact of disease on animal production.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vaccination Is a Suitable Tool in the Control of Aujeszky’s Disease Outbreaks in Pigs Using a Population Dynamics P Systems Model

Colomer

Margalida

Fraile

2020

Animals

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“…The disease was first reported in cattle in 1813 [ 2 ] and became endemic in European swine farms in the 1940s. A highly virulent PRV strain was reported in parts of the United States in the 1960s [ 3 , 4 ]. Highly virulent PRV strains were also reported in China during the same period, which caused significant economic losses to the pig industry [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Yunnan Variants of the Pseudorabies Virus and Their Pathogenicity in Rats

Song,

Ye,

Zhang

et al. 2024

Viruses

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Porcine pseudorabies has long existed in China and is a serious threat to the Chinese farming industry. To understand the prevalence and genetic variation of the porcine pseudorabies virus (PRV) and its pathogenicity in Yunnan Province, China, we collected 560 serum samples across seven Yunnan Province regions from 2020 to 2021 and detected anti-gE antibodies in these samples. Sixty-one clinical tissue samples were also collected from pigs with suspected PRV that were vaccinated with Bartha-K61. PRV-gE antibodies were found in 29.6% (166/560) of the serum samples. The PRV positivity rate in clinical tissue samples was 13.1% (8/61). Two isolates, PRV-KM and PRV-QJ, were obtained. The identity of the gB, gD, and gE genes between these isolates and the Chinese mutants exceeded 99.5%. These isolates and the classical Fa strain were used to infect 4-week-old rats intranasally to assess their pathogenicity. All infected rats showed the typical clinical and pathological features of PRV two days post-infection. The viral loads in the organs differed significantly among the infected groups. Viruses were detected in the saliva and feces at 12 h, while blood changes were noted at 24 and 48 h in PRV-infected rats. These results show that mutant PRV strains are prevalent in Bartha-K61-vaccinated pigs in Yunnan Province, China. Moreover, rats shed PRV in their saliva and feces during early infection, indicating the need for rodent control in combatting PRV infections in Yunnan Province, China.

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“…Latently infected pigs are healthy virus carriers and act as potentially sources to shed and spread infectious virus to naïve individuals (Enquist, 1994;van Nes, 2001). Although PRV can be detected in neural tissues from latently infected animals by qPCR or recovered from tissue explants by virus isolation, it cannot be detected in ante-mortem diagnostic specimens using routine diagnostic procedures Tanaka and Mannen, 2014).…”

Section: Prv Diagnosticmentioning

confidence: 99%

Contemporary diagnostic approaches for pseudorabies (Aujeszky's disease) virus based on swine oral fluid specimens

Cheng¹

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Epidemiology: Mathematical modelling of pseudorabies virus (Syn. Aujeszky's disease virus) outbreaks aids eradication programmes: A review

Cited by 9 publications

References 31 publications

Vaccination Is a Suitable Tool in the Control of Aujeszky’s Disease Outbreaks in Pigs Using a Population Dynamics P Systems Model

Vaccination Is a Suitable Tool in the Control of Aujeszky’s Disease Outbreaks in Pigs Using a Population Dynamics P Systems Model

Isolation and Characterization of Yunnan Variants of the Pseudorabies Virus and Their Pathogenicity in Rats

Contemporary diagnostic approaches for pseudorabies (Aujeszky's disease) virus based on swine oral fluid specimens

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