Epidemiology of acute asthma: IgE antibodies to common inhalant allergens as a risk factor for emergency room visits

Pollart, Susan M.; Chapman, Martin D.; Fiocco, Guy P.; Rose, Gail; Platts‐Mills, Thomas A.E.

doi:10.1016/0091-6749(89)90100-0

Cited by 320 publications

(119 citation statements)

References 27 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…These were followed by sensitivity to indoor allergens, which included the house dust mites (16%), cockroach allergen (14%) and cat allergen (12%). It is interesting to note that these findings are consistent with a report by Pollart et al 5 from a case control study in Virginia, where the relative risk of asthma was estimated to be 10-fold in the presence of elevated IgE to at least one of the following: ryegrass, ragweed, mite, cockroach or cat allergens. The same panel of allergens, which were reported by Pollart et al, were detected as significant in this study, except for ragweed, which was replaced by Bermuda grass.…”

Section: Discussionsupporting

confidence: 81%

“…4 However, Pollart et al have demonstrated that the presence of specific IgE antibodies to allergens was an important risk factor for acute asthma in adults. 5 Many other reports have also shown a correlation of atopic status with asthma severity in young adults. [6][7][8][9][10][11] The aim of this study was to determine the frequency of sensitization to inhalant and food allergens in adult asthmatic patients with a history of allergy in Riyadh.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The Frequency of IgE Antibodies Specific to Inhalant and Food Allergens in Adult Asthmatic Patients in Riyadh, Saudi Arabia

Gad-El-Rab

1999

Ann Saudi Med

View full text Add to dashboard Cite

The number of studies examining the influence of allergies on the natural history of asthma in adults is relatively few. Most of these patients are thought to have intrinsic asthma and, therefore, allergy evaluation is not performed as a routine investigation. However, recent studies have provided some evidence that allergy may play a role in adults with asthma. It has been shown that the frequency of immediate skin test reactivity in these patients was high, ranging from 58% to 80%.1,2 A recent study by Lin et al. demonstrated that 48.1% of adult asthmatic patients have immediate skin test reactivity to at least one of the 25 common allergens tested.3 On the other hand, Inouye et al. showed that the intensity of skin test reactivity in adults was not associated with increased severity of asthma. 4 However, Pollart et al. have demonstrated that the presence of specific IgE antibodies to allergens was an important risk factor for acute asthma in adults.5 Many other reports have also shown a correlation of atopic status with asthma severity in young adults. 6-11The aim of this study was to determine the frequency of sensitization to inhalant and food allergens in adult asthmatic patients with a history of allergy in Riyadh. Such information has never been reported before in this region. The types of allergens to which the patients reacted and the optimal number that can be used as a screening panel for allergy evaluation were presented and discussed. Patients and MethodsThe study group included 100 consecutive adult asthmatic patients referred to the Allergy Clinic at King Khalid University Hospital for evaluation of possible allergic factors. Since not all the patients with asthma in the hospital have allergy evaluation routinely, this referral was based on a suggestive medical history. This included patients who suspect an association between exposure to certain provoking factors or ingestion of certain foods and precipitation or aggravation of their symptoms. Their ages ranged between 19 to 65 years and the male to female ratio was 2:1. The diagnosis of asthma was based on a compatible clinical history and the presence of variable airflow obstruction as demonstrated by an improvement in FEV1 of greater than 15% after bronchodilator. CAP RAST AssayBlood samples were obtained from the patients and the serum separated and stored at -70°C until assayed. The samples were tested for the presence of specific IgE antibodies to inhalant and food allergens by the new Pharmacia CAP System RAST FEIA (Uppsala, Sweden), which has already been shown to be very sensitive. The panel of inhalant and food allergens included in the test appear in Tables 1 and 2. The patient's serum was added to the allergen of interest, which was covalently coupled to immunoCAP. After washing away nonspecific IgE, enzymelabelled antibodies against IgE were added to form a complex. After incubation, unbound enzyme anti-IgE was washed away and the bound complex was then incubated with a developing agent. After stopping the reaction, the fluorescence...

show abstract

Section: Discussionsupporting

confidence: 81%

mentioning

confidence: 99%

The Frequency of IgE Antibodies Specific to Inhalant and Food Allergens in Adult Asthmatic Patients in Riyadh, Saudi Arabia

Gad-El-Rab

1999

Ann Saudi Med

View full text Add to dashboard Cite

show abstract

“…In this study we found a significant association, though we measured atopy in adulthood. Outdoor allergens in adults have been related with epidemic and endemic presentations of emergency room admissions for asthma [23,24]. This suggests that seasonal allergens might have an important role in asthma during adulthood, as we found in the analysis of the independent association of common aeroallergens with bronchial responsiveness [25].…”

Section: Discussionmentioning

confidence: 68%

Risk factors for asthma in young adults. Spanish Group of the European Community Respiratory Health Survey

Sunyer¹,

Antó²,

Kogevinas³

et al. 1997

Eur Respir J

View full text Add to dashboard Cite

We assessed the association of asthma prevalence in young adults with susceptibility factors and environmental exposures, taking into account the age at asthma onset.A random sample of the general population, aged 20-44 yrs, in five areas of Spain (Albacete, Barcelona, Galdakao, Huelva, and Oviedo) was selected in the frame of the European Community Respiratory Health Survey (ECRHS). Overall, 2,646 subjects (response rate = 60.9%) responded to a respiratory questionnaire and 1,797 (41.4%) finalized a bronchial challenge.Atopy to perennial (odds ratio (OR) = 10.2, 95% confidence interval 4.2-25) and seasonal allergens (11.5, 4.6-28), parental asthma (4.5, 2.5-8.4), and birth order (OR for no older siblings in comparison to having more than two = 3.2, 1.2-9.1) were associated with current asthma whatever the age of asthma onset. Past asthma was associated to a lesser extent with atopy (OR around 3.5 to both perennial and seasonal allergens). Lower respiratory tract infections before the age of 5 yrs (LRTI), having had a pet in childhood, and being born in a younger cohort were associated with asthma starting before the age of 15 yrs, but not after. Male gender was more frequent in childhood asthma and female gender in adulthood.In addition to the known risk factors of asthma (atopy to perennial allergens, parental asthma) we provide evidence for an association of asthma (whatever the age of onset) with sensitization to seasonal allergens, and having less than three older siblings; and for an association of childhood asthma with lower respiratory tract infections. Eur Respir J 1997; 10: 2490-2494 The role of many risk factors involved in the onset of asthma and exacerbation remains, in part, controversial. The production of specific immunoglobulin E (IgE) antibodies in response to environmental allergens (atopy) has been strongly associated with asthma [1]. Allergen exposure in sensitized children is known to initiate an immediate and late cellular airway reaction and bronchial obstruction [2]. However, though asthma is strongly associated with atopy, it only occurs in a proportion of atopics [3]. It is unclear to what extent asthma relates to the type of allergen (due to a different potency, such as the supposed supremacy of Dermatophagoides pteronyssinus [4,5]) rather than to the level of allergen in the environment (as occurred in places without D. pteronyssinus [6]). In addition, viral infections in early life may protect [7] or, in contrast, enhance [8] the sensitization process. In adulthood, high exposures to new allergens, such as occupational allergens [9], may mimic the sensitization process occurring in early life. Other factors in adulthood, such as exposure to irritants [10] have been proposed as contributors to the persistence of asthma at that age.Asthma is a chronic episodic disease initiated in childhood in many subjects [11]. Although the overall features of asthma are similar in children and adults, there are numerous distinctions [12]. Thus, the study of risk factors involved in asthma...

show abstract

“…Studies investigating the association between mite allergen exposure and asthma in children have produced confl icting results. For example, in children with at least one atopic parent, Sporik et al [4] showed an increased risk of asthma at 11 years of age with exposure to high concentrations of mite allergens (> 10 μg/g dust), however, these results were not confi rmed by later studies [26][27][28]. The prospective study following a large birth cohort that included both low-risk and high-risk children has been reported by the Multicenter Allergy Study Group [28].…”

Section: Ijomeh 2007;20(2) 123mentioning

confidence: 44%

“…The observed increase in indoor allergen exposure, particularly house-dust mites (HDM), is one of the candidate risk factors that is potentially involved. HDM exposure during early childhood may lead to allergic sensitivity, airway infl ammation and asthma in children [4][5][6][7][8][9][10]. Some authors hypothesize that the content of HDM allergen exceeding 2.0 μg/g dust may be regarded as a risk level of sensitization [4,6].…”

Section: Introductionmentioning

confidence: 99%

Risk of Wheezing Associated with House-dust Mite Allergens and Indoor Air Quality Among Three-year-old Children. Kraków Inner City Study

Jeedrychowski

Maugeri²,

Zembala³

et al. 2007

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Objectives: The aim of the study was to describe the distribution of house-dust mite (HDM) allergens in homes of threeyear-old children and to test the hypothesis whether the content of HDM allergens exceeding 2 μg/g of dust may be regarded as a risk level possibly affecting respiratory health in early childhood. Materials and Methods: House-dust samples were collected in 275 dwellings from mattresses, children's bedrooms and kitchen fl oors. In the laboratory, dust samples were analyzed for Der f 1 and Der p 1 using monoclonal antibody enzyme-linked immunosorbent assays (ELISA). At the time of the house-dust collection, mothers were interviewed on the household characteristics and their children's respiratory health. Respiratory outcome variables included wheezing or whistling in the chest irrespective of respiratory infections. The number of the wheezing episodes and their duration in days over the last 6 months were recorded in the questionnaire. In the multivariate Poisson regression analysis on the association between the occurrence of wheezing and exposure, a set of potential confounders, such as child's gender, maternal education, maternal allergy, older siblings, presence of moulds, house dampness, and environmental tobacco smoke (ETS) was taken into account. Results: The adjusted incidence rate ratios (IRR) of wheezing ascribed to a higher HDM level (> 2.0 μg/g dust) were 1.84 (95% CI: 1.45-2.34) for duration of wheezing and 1.56 (95% CI: 0.88-2.75) for episodes. Of the confounders taken into consideration, the presence of moulds had the strongest impact on the risk of wheezing (IRR = 4.24; 95% CI: 3.08-5.84). Conclusion: The data support the view that exposure to a higher level of HDM allergens increases the burden of respiratory diseases in the early childhood and the effect is independent of maternal atopy, ETS, and moulds in homes.

show abstract

Epidemiology of acute asthma: IgE antibodies to common inhalant allergens as a risk factor for emergency room visits

Cited by 320 publications

References 27 publications

The Frequency of IgE Antibodies Specific to Inhalant and Food Allergens in Adult Asthmatic Patients in Riyadh, Saudi Arabia

The Frequency of IgE Antibodies Specific to Inhalant and Food Allergens in Adult Asthmatic Patients in Riyadh, Saudi Arabia

Risk factors for asthma in young adults. Spanish Group of the European Community Respiratory Health Survey

Risk of Wheezing Associated with House-dust Mite Allergens and Indoor Air Quality Among Three-year-old Children. Kraków Inner City Study

Contact Info

Product

Resources

About