Epidemiology of alopecia areata in the Hispanic/Latinx community: A cross-sectional analysis of the All of Us database

Joshi, Tejas P; Garcia, Danielle; Gedeon, Francesca; Hinson, Darien; Strouphauer, Emily; Okundia, Fyona; Tschen, Jaime A.

doi:10.1016/j.jaad.2023.02.054

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…We also observed an association between rs3104394 in MTCO3P1 with alopecia areata only in the AMR population (P AFR = 0.01, P AMR = 1.27 × 10 −11 , P EUR = 7.66 × 10 −6 ). Although there is no information available about the relationship between the MTCO3P1 gene and alopecia, a cross sectional analysis of the NIH All of US cohort found that alopecia areata is more prevalent in Hispanic/Latinx individuals, suggesting potential genetic factors contributing to the development of this condition ( 17 ).…”

Section: Resultsmentioning

confidence: 99%

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

Verma,

Huffman,

Rodriguez

et al. 2024

Science

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One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and understand the genetic causes of health disparities. We present genome-wide associations for 2068 traits from 635,969 participants in the Department of Veterans Affairs Million Veteran Program, a longitudinal study of diverse United States Veterans. Systematic analysis revealed 13,672 genomic risk loci; 1608 were only significant after including non-European populations. Fine-mapping identified causal variants at 6318 signals across 613 traits. One-third ( n = 2069) were identified in participants from non-European populations. This reveals a broadly similar genetic architecture across populations, highlights genetic insights gained from underrepresented groups, and presents an extensive atlas of genetic associations.

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Section: Resultsmentioning

confidence: 99%

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

Verma,

Huffman,

Rodriguez

et al. 2024

Science

View full text Add to dashboard Cite

show abstract

“…We also identified a novel association of rs3104394 in MTCO3P1 with alopecia areata reached experiment-wide significance only in AMR (P AFR = 0.01, P AMR = 1.27 x 10 -11 , P EUR = 7.66 x 10 -6 ). Although there is no information available about the relationship between the MTCO3P1 gene and alopecia, a cross-sectional analysis of the NIH 'All of Us' cohort found that alopecia areata is more prevalent in the Hispanic/Latinx community, suggesting potential genetic factors contributing to the development of this condition (31).…”

Section: Multi-population Meta-analysis Improves the Power To Detect ...mentioning

confidence: 99%

Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program

Verma

Huffman

Rodríguez

et al. 2023

Preprint

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Genome-wide association studies (GWAS) have underrepresented individuals from non-European populations, impeding progress in characterizing the genetic architecture and consequences of health and disease traits. To address this, we present a population-stratified phenome-wide GWAS followed by a multi-population meta-analysis for 2,068 traits derived from electronic health records of 635,969 participants in the Million Veteran Program (MVP), a longitudinal cohort study of diverse U.S. Veterans genetically similar to the respective African (121,177), Admixed American (59,048), East Asian (6,702), and European (449,042) superpopulations defined by the 1000 Genomes Project. We identified 38,270 independent variants associating with one or more traits at experiment-wide (P < 4.6x10-11) significance; fine-mapping 6,318 signals identified from 613 traits to single-variant resolution. Among these, a third (2,069) of the associations were found only among participants genetically similar to non-European reference populations, demonstrating the importance of expanding diversity in genetic studies. Our work provides a comprehensive atlas of phenome-wide genetic associations for future studies dissecting the architecture of complex traits in diverse populations.

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Epidemiology of alopecia areata in the Hispanic/Latinx community: A cross-sectional analysis of the All of Us database

Cited by 2 publications

References 3 publications

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program

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