Epidemiology of and Risk Factors for Harmful Anti-Infective Medication Errors in a Pediatric Hospital

Modi, Anjali; Germain, Ellen; Soma, Vijaya L; Munjal, Iona; Rinke, Michael L.

doi:10.1016/j.jcjq.2018.03.001

Cited by 1 publication

(1 citation statement)

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“…In a study conducted by Modi et al ., 63% of the reported 338 medication errors in a pediatric hospital were related to the usage of β-lactam antimicrobial drugs and 6% were related to both macrolide and glycopeptide group. [37] In pediatric clinical practice in Iran, infectious diseases of children are mostly diagnosis clinically, and empirical treatment is started before pathogen identification. Paying enough attention to identifying the responsible pathogens for the illness in bacterial infections in different age groups affects drug selection and may have further impacts on drug dose selection, dose intervals, and oral or injection usage in the pharmacotherapy infections in the pediatric population.…”

Section: Discussionmentioning

confidence: 99%

The responsibility of clinical pharmacists for the safety of medication use in hospitalized children: A Middle Eastern experience

et al. 2019

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Objective: We aimed to detect and report the frequency of occurrence of drug-related problems (DRPs) in a Middle Eastern University Children's Hospital (Isfahan, Iran) and classify them in terms of their nature and cause to clarify the responsibility of clinical pharmacists for the safe utilization of medications in hospitalized children. Methods: In this cross-sectional study which was carried out in Imam Hossein Children's University Hospital affiliated with Isfahan University of Medical Sciences (Isfahan, Iran) from September 2017 to May 2018, DRPs during the hospitalization of pediatric patients in three medical wards, the pediatric intensive care unit, and two neonatal intensive care units were detected and identified concurrently with the treatment process using Pharmaceutical Care Network of Europe data gathering form for DRPs v. 8.01. All cases were verified and validated in a professional focus group before documentation. Findings: We detected 427 DRPs in 201 out of 250 randomly included hospitalized children in which 86% of them were directly reported by the hospital's clinical pharmacist. The highest frequency of DRPs (47.3%) was observed in the age range of 1 month–2 years. Safety of treatment was the most frequently reported as the nature of the problem (43.5%), followed by effectiveness issues (36.8%). The most frequent cause of DRPs was dose selection issues (34.2%), followed by drug-type selection (25.5%), and unavailability of appropriate dosage forms (13.6%). Ninety-eight interventions were proposed by the clinical pharmacist, in which 59.2% of them were accepted. Conclusion: This study confirms the necessity for the active role of clinical pharmacists before, during, and after drug therapy in hospitalized pediatric patients for the safety and proper utilization of drugs in this vulnerable population.

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Section: Discussionmentioning

confidence: 99%