Epidemiology of ankylosing spondylitis in rochester, minnesota, 1935–1973

Abstract

The Mayo Clinic records linkage facility for residents of Rochester, Minnesota, Yielded 102 cases of ankylosing spondylitis (AS) diagnosed from 1935 through 1973. The incidence did not change significantly over the 39 years. Three times as many males as females were affected. In contrast to another recent report, survivorship of males with AS was not different from that of the general population, whereas survivorship of females with AS was reduced. The overall prevalence was 129/100,000.

Cardiovascular Manifestations of Rheumatologic Diseases

“…The prevalence of ankylosing spondylitis is Ϸ1 to 2 per 1000 among whites with a 3:1 to 4:1 male predominance. 1,105,106 Onset of clinical features usually begins in the third to fourth decades. Roughly 90% of affected individuals are HLA-B27 positive, with racial prevalences of ankylosing spondylitis varying according to HLA-B27 frequency (lower in blacks and higher in American Indians).…”

Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis: A randomized, controlled trial

“…Approximately 350,000 people in the US have AS (1). Traditional therapies, including diseasemodifying antirheumatic drugs (DMARDs), nonsteroidal antiinflammatory drugs (NSAIDs), and corticosteroids, do not adequately control disease activity in most patients (2).…”

Ankylosing spondylitis and sarcoidosis —Coincidence or association? Case report and review of the literature

“…Based on epidemiological data there is no reason to assume an association of the two entities each having a relatively high prevalence. The prevalence of ankylosing spondylitis is reported as 1 per 1000 population (10), and the prevalence of sarcoidosis varies from 0.04 in Spain to 64 per 1000 population in Sweden (11). Therefore, based on pure coincidence, prevalence data for the two disorders are to be expected in the order of 0.00004 to 0.064 per 1000, the numbers being even higher if association of the two diseases is assumed.…”