Epidemiology of antimalarial-induced pruritus in Africans

Ajayi, A. A.; Oluokun, A; Sofowora, Olaniyi Alaba; Akinleye, Akintunde

doi:10.1007/bf00558141

Cited by 42 publications

(47 citation statements)

References 4 publications

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“…The results showed a peak of pruritus in R + subjects between 6 to 30 h after taking the chloroquine tablets, consistent with the report of Ajayi et al [4]. The duration of pruritus was about 2 days, especially in the subjects who complained of intolerable pruritus, again consistent with the data of Ajayi et al [4].…”

supporting

confidence: 93%

“…The duration of pruritus was about 2 days, especially in the subjects who complained of intolerable pruritus, again consistent with the data of Ajayi et al [4]. 10 ~AA Those with pruritus lasting for about 2 day represented 56% of the total subjects (100 out of 176).…”

supporting

confidence: 84%

“…The ratio of R + to NR in the Ajayi et al data is similar to the frequency of the haemoglobin S gene in this area [5,6]. It was an interesting proposition therefore, to determine if the presence of the HbS gene, which is known to protect against malaria [7], had any connection with chloroquine-induced pruritus in Africans, who are known to be susceptible to the nasty pruritus [4] and to the sickle cell gene.…”

mentioning

confidence: 66%

“…Ajayi et al [4] collected extensive data on antimalarialinduced pruritus in Africans. Sixty one of their large sample (n = 1,100) 61% were found to have chloroquineinduced pruritus.…”

mentioning

confidence: 99%

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Chloroquine-induced pruritus and sickle cell gene trait in Africans: Possible pharmacogenetic relationship

Ogunranti

Aguiyi

Roma

et al. 1992

Eur J Clin Pharmacol

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supporting

confidence: 93%

supporting

confidence: 84%

mentioning

confidence: 66%

“…Ajayi et al [4] collected extensive data on antimalarialinduced pruritus in Africans. Sixty one of their large sample (n = 1,100) 61% were found to have chloroquineinduced pruritus.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Chloroquine-induced pruritus and sickle cell gene trait in Africans: Possible pharmacogenetic relationship

Ogunranti

Aguiyi

Roma

et al. 1992

Eur J Clin Pharmacol

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“…5-HT has also been reported to induce hyperalgesia (Lin et al 2011;Oliveira et al 2007;Taiwo and Leving 1992); however, the present results indicate that 5-HT evokes behavioral responses that are more closely associated with itch rather than pain. Chloroquine, which induces itch in humans (Ajayi et al 1989), also elicited facial scratching but not wiping. Curiously, chlo- …”

Section: Discussionmentioning

confidence: 99%

Facial injections of pruritogens or algogens elicit distinct behavior responses in rats and excite overlapping populations of primary sensory and trigeminal subnucleus caudalis neurons

Klein

Carstens

2011

Journal of Neurophysiology

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Klein A, Carstens MI, Carstens E. Facial injections of pruritogens or algogens elicit distinct behavior responses in rats and excite overlapping populations of primary sensory and trigeminal subnucleus caudalis neurons. J Neurophysiol 106: 1078 -1088. First published June 8, 2011 doi:10.1152/jn.00302.2011In the present study, we investigated whether intradermal cheek injection of pruritogens or algogens differentially elicits hindlimb scratches or forelimb wipes in Sprague-Dawley rats, as recently reported in mice. We also investigated responses of primary sensory trigeminal ganglion (TG) and dorsal root ganglion (DRG) cells, as well as second-order neurons in trigeminal subnucleus caudalis (Vc), to pruritic and algesic stimuli. 5-HT was the most effective chemical to elicit dose-dependent bouts of hindlimb scratches directed to the cheek, with significantly less forelimb wiping, consistent with itch. Chloroquine also elicited significant scratching but not wiping. Allyl isothiocyanate (AITC; mustard oil) elicited dose-dependent wiping with no significant scratching. Capsaicin elicited equivalent numbers of scratch bouts and wipes, suggesting a mixed itch and pain sensation. By calcium imaging, ϳ6% of cultured TG and DRG cells responded to 5-HT. The majority of 5-HT-sensitive cells also responded to chloroquine, AITC, and/or capsaicin, and one-third responded to histamine. Using a chemical search strategy, we identified single units in Vc that responded to intradermal cheek injection of 5-HT. Most were wide dynamic range (WDR) or nociceptive specific (NS), and a few were mechanically insensitive. The large majority additionally responded to AITC and/or capsaicin and thus were not pruritogen selective. These results suggest that primary and second-order neurons responsive to pruritogens and algogens may utilize a population coding mechanism to distinguish between itch and pain, sensations that are behaviorally manifested by distinct hindlimb scratching and forelimb wiping responses.

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