Epidemiology of Asthma

Asia is the world's most dynamic area. Asthma is a major chronic disease in Asia, like other continents. However, unlike childhood asthma, the epidemiological burden of asthma in Asian adults has been unclear. Here we reviewed the currently available literatures on the epidemiology of adult asthma in the Asian community populations. Adult asthma prevalence was generally lower in Asian than in Europe, but the increasing trends suggested the disease burden to rise in the near future. However, for better understanding, it may be essential to prepare for the Asian multinational network for the standardization and collaboration of research.

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“…Reference label indicates the first author and publication year [9, 10, 11, 12, 13, 14, 19, 28, 38, 39, 44, 51, 57]. …”

Section: Figmentioning

confidence: 99%

Epidemiology of adult asthma in Asia: toward a better understanding

Song

Kang

Chang

et al. 2014

Asia Pacific Allergy

106

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“…In Japan of 1993, Asthma Prevention and Management Guidelines (JGL) was first developed by Japanese Society of Allergology 20-22. Like GINA JGL has been produced with the concept that asthma is an inflammatory disease of the airway, and its treatment is aimed at prevention and control of airway inflammation.…”

Section: Asthma Management Guidelinesmentioning

confidence: 99%

Evolution of Asthma Concept and Effect of Current Asthma Management Guidelines

Makino

Sagara

2010

Allergy Asthma Immunol Res

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Concept of asthma has changed from symptom-complex or airway hypersensitivity to airway inflammation and airway remodeling. Based on this concept asthma management guidelines (JGL) has been developed in Japan. Death from asthma has decreased drastically since the publication of the guidelines, although it is still high in elderly population. Further works are expected for "zero-death" from asthma and for tighter control of airway inflammation and resultant airway remodeling.

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Alpha‐1‐antitrypsin and complement component C7 are involved in asthma exacerbation

Nishioka

Uchida

Meno³

et al. 2008

Proteomics Clinical Apps

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Asthma is the most common chronic disorder in childhood and asthma exacerbation is an important cause of childhood morbidity and hospitalization. Allergic responses are known to be biased toward T-helper type 2 in asthmatics; however, the pathogenesis of asthma is not simple, and our understanding of the disease mechanism remains incomplete. The aim of the present study was to identify protein expression signatures that reflect acute exacerbation of asthma. Plasma was taken twice from pediatric asthmatic patients, once during asthma exacerbation and once during a stable period. Plasma was also taken from healthy children as a control. The protein profiles of plasma during asthma exacerbation were analyzed by 2-DE and 49 spots were differentially expressed during asthma exacerbation. Thirty-eight of the spots were successfully identified by MALDI-TOF MS. Proteins up- or down-regulated during asthma exacerbation were involved in responses to stress and pathogens, in the complement and coagulation cascades, and in acute-phase responses. Among the differentially expressed proteins, up-regulation of alpha-1-antitrypsin and complement component C7 was confirmed by nephelometry and ELISA. Our present results suggest that protease inhibitors and complement components may be involved in asthma exacerbation, and plasma level of alpha-1-antitrypsin may be a potential biomarker for asthma.

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Epidemiology of Asthma

Cited by 7 publications

References 4 publications

Epidemiology of adult asthma in Asia: toward a better understanding

Epidemiology of adult asthma in Asia: toward a better understanding

Evolution of Asthma Concept and Effect of Current Asthma Management Guidelines

Alpha‐1‐antitrypsin and complement component C7 are involved in asthma exacerbation

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