Epidemiology of birth defects in teenage pregnancies: Based on provincial surveillance system in eastern China

Chen, Xinning; Lou, Haifeng; Chen, Lijin; Muhuza, Marie Parfaite Uwimana; Chen, Danqing; Zhang, Mengjie

doi:10.3389/fpubh.2022.1008028

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…Epidemiological surveys show a brief increase in the incidence of gastroschisis in North and South America and many European countries ( 29 ). There are still few studies on gastroschisis in China, and in 2022, a study on the incidence in the Chinese population showed that the incidence of gastroschisis in the offspring of patients under 20 years of age was 10.62 per 10,000 live births; however, the incidence of gastroschisis in the offspring of parents between the ages of 25 and 29 years was 1.51 per 10,000 live births ( 11 ). The same findings suggest that the offspring of pregnant adolescents are at high risk of gastroschisis ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

“…In a study on birth defects in the Chinese population, the incidence of gastroschisis in the offspring of patients under 20 years of age was 10.62 per 10,000 live births; however, the incidence of gastroschisis in the offspring of parents between the ages of 25 and 29 years was 1.51 per 10,000 live births ( 11 ). Additionally, the prevalence of gastroschisis has increased, from 3.6 per 10,000 live births in 1995–2005 to 4.9 per 10,000 live births in 2006–2012 ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

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Case Report: foetal gastroschisis with ideal pregnancy outcomes under multidisciplinary treatment management

Liu,

Qian,

et al. 2024

Front. Pediatr.

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BackgroundGastroschisis has increased in recent years, however, complicated gastroschisis is associated with higher mortality, as well as higher health care costs and disease burdens from short- and long-term complications.Case introductionA woman aged 25 years old at 37 + 1 weeks gestation (gravida 2; para 0) was admitted to the hospital because of foetal gastroschisis. Targeted quaternary ultrasound performed at our hospital showed that 34 mm of the abdominal wall was interrupted continuously, an intestinal echo with a range of approximately 88 × 50 mm was seen bulging outwards the local area close to the intestinal wall showed a 34 × 23 m anecho, and the foetus was measuring 2 weeks smaller than expected. After MDT including the maternal-foetal medicine, ultrasound, paediatric surgery, neonatal intensive care unit (NICU), and anaesthesiology departments, caesarean section was performed at 37 + 2 weeks. A baby boy was delivered, the small intestine, large intestine and stomach were seen outside of the abdomen, the abdominal cavity was excluded from the defect on the right side of the umbilical cord, the mesentery was shortened, and the intestinal tube had obvious oedema After paediatric surgical discussion, silo bag placement and delayed closure was performed, the placement process was smooth. One week following silo placement, the abdominal contents had been fully reduced below the fascia following daily partial reductions of the viscera,and the second stage of the operation was performed under general anaesthesia. The newborn was successfully discharged from the hospital 20 days after the operation and was followed up, with good growth, normal milk intake and smooth bowel movements.ConclusionsThe diagnosis and treatment of complicated gastroschisis needs to be carried out under multidisciplinary team treatment. Delivery by cesarean section after 37 weeks is feasible.Immediate postpartum surgery is possible, and the choice of surgical modality is determined by the child's condition, emphasizing that it should be performed without adequate sedation under anaesthesia. A standardized postoperative care pathway appropriate to risk should be developed to optimize nutritional support and antibiotic use, and standardized enteral feeding practices should be sought with long-term follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Case Report: foetal gastroschisis with ideal pregnancy outcomes under multidisciplinary treatment management

Liu,

Qian,

et al. 2024

Front. Pediatr.

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“…Congenital anomalies not only seriously affect the survival and quality of life of children but also cause great pain and heavy economic burden on families and society ( Boyd et al, 2008 ; Heaney, Tomlinson & Aventin, 2022 ). Owing to environmental pollution, deficiencies in maternal nutrition, radiation exposure, poor lifestyle habits, and advanced maternal age, China has a high incidence of birth defects ( Chen et al, 2022 ; Ghazi et al, 2021 ; Tan, Sethi & Sulaiman, 2022 ; Zhang et al, 2020 ) of approximately 5.6%, equivalent to approximately 900,000 new birth defects every year ( Li & Di, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The status and influencing factors of abnormal fetal pregnancy outcomes in 265 cases in China: a retrospective study

Ruan,

Zhong,

Mai

et al. 2024

PeerJ

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Background With the advancement of prenatal diagnosis technology, the detection rate of fetal abnormalities continues to increase, imposing a significant burden on both society and families. A retrospective analysis of essential information about pregnant women, such as their pregnancy history and delivery details, is crucial for understanding the primary factors that influence pregnancy outcomes in women with fetal abnormalities. This analysis is of great significance for improving the level of pregnancy management and outcomes in pregnant women with fetal abnormalities. Objective To retrospectively analyze the pregnancy outcomes of women with fetal abnormalities and explore the factors that influence these outcomes. Methods Pregnant women’s pregnancy outcomes were collected from the medical information system and through telephone follow-ups. The chi-square test and logistic regression were used to analyze the factors influencing pregnancy outcomes. Results Among 265 pregnant women diagnosed with fetal abnormalities, 190 chose to continue the pregnancy, while 75 chose to terminate it. Pregnant women with multiple fetal abnormalities (OR = 3.774, 95% CI [1.640–8.683]) were more likely to choose termination of pregnancy (TOP), and pregnant women who were advised to terminate their pregnancy or make a careful choice were more likely to terminate the pregnancy (OR = 41.113, 95% CI [11.028–153.267]). Conclusion The number of organs involved in fetal abnormalities and treatment recommendations were identified as the primary factors influencing pregnancy outcomes. Improving awareness of maternal health care during pregnancy, early pregnancy screening technology, and a multidisciplinary diagnosis and treatment approach are of great significance in assisting pregnant women in making informed decisions and improving fetal prognosis.

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“…Sufficiency during pregnancy is important for normal fetal development [ 18 ]. Folate deficiency is associated with adverse outcomes including maternal anemia, neural tube defects, and birth defects [ 19 , 20 ]. However, because folic acid in natural foods is easily broken down during cooking and processing, the amount of folic acid alone is insufficient for pregnant women due to this loss.…”

Section: Introductionmentioning

confidence: 99%

Serum Folate, Red Blood Cell Folate, and Zinc Serum Levels Are Related with Gestational Weight Gain and Offspring’s Birth-Weight of Adolescent Mothers

Sámano,

Martínez-Rojano,

Chico-Barba

et al. 2024

Nutrients

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Background: Gestational weight gain below or above the Institute of Medicine recommendations has been associated with adverse perinatal and neonatal outcomes. Very few studies have evaluated the association between serum and red blood cell folate concentrations and gestational weight gain in adolescents. Additionally, zinc deficiency during pregnancy has been associated with impaired immunity, prolonged labor, preterm and post-term birth, intrauterine growth restriction, low birth weight, and pregnancy-induced hypertension. Objective: The purpose of our study is to evaluate the association between serum concentrations of zinc, serum folate, and red blood cell folate, with the increase in gestational weight and the weight and length of the newborn in a group of adolescent mothers from Mexico City. Results: In our study, 406 adolescent-neonate dyads participated. The adolescents’ median age was 15.8 years old. The predominant socioeconomic level was middle-low (57.8%), single (57%), 89.9% were engaged in home activities, and 41.3% completed secondary education. Excessive gestational weight gain was observed in 36.7% of cases, while insufficient gestational weight gain was noted in 38.4%. Small for gestational age infants were observed in 20.9% of the sample. Low serum folate (OR 2.1, 95% CI 1.3–3.3), decreased red blood cell folate (OR 1.6, 95% CI 1.0–2.6), and reduced serum zinc concentrations (OR 3.3, 95% CI 2.1–5.2) were associated with insufficient gestational weight gain. Decreased serum zinc levels (OR 1.2, 95% CI 1.2–3.4) were linked to an increased probability of delivering a baby who is small for their gestational age. Conclusions: Low serum folate, red blood cell folate, and serum zinc concentrations were associated with gestational weight gain and having a small gestational age baby. Both excessive and insufficient gestational weight gain, as well as having a small gestational age baby, are frequent among adolescent mothers.

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Epidemiology of birth defects in teenage pregnancies: Based on provincial surveillance system in eastern China

Cited by 7 publications

References 37 publications

Case Report: foetal gastroschisis with ideal pregnancy outcomes under multidisciplinary treatment management

Case Report: foetal gastroschisis with ideal pregnancy outcomes under multidisciplinary treatment management

The status and influencing factors of abnormal fetal pregnancy outcomes in 265 cases in China: a retrospective study

Serum Folate, Red Blood Cell Folate, and Zinc Serum Levels Are Related with Gestational Weight Gain and Offspring’s Birth-Weight of Adolescent Mothers

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