Epidemiology of bloodstream infections caused by methicillin-resistant Staphylococcus aureus at a tertiary care hospital in New York

Yasmin, Mohamad; Hage, Halim El; Obeid, Rita; Haddad, Hanine El; Zaarour, Mazen; Khalil, Ayman

doi:10.1016/j.ajic.2015.08.005

Cited by 16 publications

(8 citation statements)

References 39 publications

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“…Similarly, Bradley et al14 reported that 12% of patients who newly acquire MRSA are hospitalized with an MRSA infection in the subsequent 18 months. Our study also correlates with the results of Yasmin et al4 who reported that the majority of CO-MRSA bacteremia cases were due to skin and soft tissue infections. Yasmin et al4 also found that having a central line within the previous 30 days was an independent risk factor with a calculated OR of 80 (95% CI, 2–3014).…”

Section: Discussionsupporting

confidence: 92%

“…Staphylococcus aureus bacteremia (SAB) is the second-most common cause of community-onset (CO) bacteremia, affecting 15–40 per 100,000 population per year 1,2. It is associated with a 20% mortality rate3,4 with higher mortality linked to the presence of methicillin resistance, comorbid conditions, intensive care unit admission, and prior exposure to antibiotics 5. Three-quarters of SAB are CO bacteremia, with the majority being secondary to skin and soft tissue infections.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of Community-Onset Staphylococcus aureus Bacteremia

Yarovoy

Monte

Knepper

et al. 2019

WestJEM

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Introduction Staphylococcus aureus bacteremia (SAB) is the second-most common cause of community-onset (CO) bacteremia. The incidence of methicillin-resistant S. aureus (MRSA) has recently decreased across much of the United States, and we seek to describe risk factors for CO-MRSA bacteremia, which will aid emergency providers in their choice of empiric antibiotics. Methods This is a retrospective cohort study of all patients with SAB at a 500-bed safety net hospital. The proportion of S. aureus isolates that were MRSA ranged from 32–35% during the study period. Variables of interest included age, comorbid medical conditions, microbiology results, antibiotic administration, duration of bacteremia, duration of hospital admission, suspected source of SAB, and Elixhauser comorbidity score. The primary outcome was to determine risk factors for CO-MRSA bacteremia as compared to methicillin-susceptible S. aureus (MSSA) bacteremia in patients admitted to the hospital through the emergency department. Results We identified 135 consecutive patients with CO-SAB. In comparison to those with MSSA bacteremia, patients with MRSA bacteremia were younger (odds ratio [OR] 0.5, 95% confidence interval [CI], 0.4–0.7) with higher Elixhauser comorbidity scores (OR 1.4, 95% CI, 1.1–1.7). Additionally, these patients were more likely to have a history of MRSA infection or colonization (OR 8.9, 95% CI, 2.7–29.7) and intravenous drug use (OR 2.4, 95% CI, 1.0–5.7). Conclusion SAB continues to be prevalent in our urban community with CO-MRSA accounting for almost one-third of SAB cases. Previous MRSA colonization was the strongest risk factor for current MRSA infection in this cohort of patients with CO-SAB.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Epidemiology of Community-Onset Staphylococcus aureus Bacteremia

Yarovoy

Monte

Knepper

et al. 2019

WestJEM

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“…Because MRSA is an important pathogen and indicates a higher risk of contracting S. aureus infection [ 14 ], it was necessary to analyze the variation in MRSA infection frequency in key hospital departments during the same 7-year period. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Drug-resistance dynamics of Staphylococcus aureus between 2008 and 2014 at a tertiary teaching hospital, Jiangxi Province, China

et al. 2017

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BackgroundTo understand the relationship between the Staphylococcus aureus infection rate and the reasonable usage of antibiotics, which will help in the effective control of MRSA infection.MethodsAll data were obtained by the application of the nosocomial infection surveillance network. Drug resistance, departmental sources, and isolated sites as well as infection rate variations of S. aureus were analyzed in the 7-year period in key departments.ResultsBetween 2008 and 2014, 2525 strains of S. aureus isolates, mainly from sputum, skin/soft tissue, bloodstreams were collected from several hospital departments including respiratory, burn, brain surgery, orthopedics, ICU, and emergency. During these periods, the resistance rate of S. aureus to most drugs, including oxacillin, tetracycline, erythromycin, clindamycin, gentamicin, and ciprofloxacin, showed a tendency to decrease. The resistance to sulphamethoxazole/trimethoprim showed the opposite trend (P = 0.075) and there were no S. aureus strains resistant to linezolid and vancomycin. The MRSA infection rate was different across crucial hospital departments, with the burns department and ICU maintaining a high infection level. Over the 7-year period, both the brain surgery and the emergency departments had an expected upward trend (P < 0.05), while the orthopedic department showed a clear downward trend (P < 0.05) in MRSA infection rate.ConclusionHospitals should continue to maintain the current pattern of antibiotic administration, while more effective measures should be taken to reduce the high MRSA infection rate in some important hospital departments.

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“…Staphylococcus aureus (S. aureus) is a major pathogen of human infection that causes diseases ranging from minor skin infections to severe bacteremia, necrotizing pneumonia, and lifethreatening sepsis (1)(2)(3), and thus is a major global threat to human health. S. aureus can colonize multifarious body regions, including the anterior nares (4), skin (5), intestinal tract (6), oropharynx (7), and so on.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Characterization, and Drug Resistance of Staphylococcus Aureus in Feces From Pediatric Patients in Guangzhou, China

Gao

Yao

et al. 2020

Front. Med.

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Background: Staphylococcus aureus (S. aureus) is a major pathogen of human infections. Its fecal carriage serves as a risk factor for nosocomial transmission and disease development. However, the rate of S. aureus fecal carriage among Chinese children has not yet been reported. Therefore, we sought to investigate the prevalence, characterization, and drug resistance of S. aureus isolated from pediatric patients' feces in Southern China. Methods: Fecal samples (2059) from pediatric patients in three centers in Guangzhou were cultured. From which, 412 S. aureus isolates were identified via selective mediums and automated VITEK Mass Spectrometer analysis. Antibiotic susceptibility was determined and DNA sequencing of seven housekeeping genes were used for multilocus sequence typing analysis. Results: The fecal carriage rates were 20.0% for S. aureus and 4.5% for methicillin-resistant S. aureus (MRSA). Moreover, S. aureus fecal carriage was positively correlated with outpatient status and gastroenteritis diagnosis. Moreover, age-related patterns were observed with respect to prevalence of S. aureus. Besides, a total of 76 sequence types (STs) were identified, including 25 newly assigned STs and 28 clonal complexes (CCs). ST188, ST6, and ST15 were the most prevalent methicillin-sensitive S. aureus (MSSA) clones, while ST59 and ST45 were the major MRSA clones. S. aureus isolates also exhibited high rates of penicillin (84.2%), erythromycin (38.8%), and clindamycin (35.9%) resistance. Specifically, all ST30 and ST338 isolates were resistant to erythromycin and clindamycin, 61% of ST7 were resistant to tetracycline, and 84% of ST45 exhibited resistance and intermediate resistance to rifampicin. Also, CC59 (ST338 and ST59) and CC45 exhibited different antibiotic resistance patterns. Conclusion: These results demonstrate the colonization dynamics and molecular epidemiology of S. aureus in child feces in Southern China. Further, they suggest an urgency for strengthening the surveillance programs in China and provide important information for the prevention and treatment of S. aureus infection.

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Epidemiology of bloodstream infections caused by methicillin-resistant Staphylococcus aureus at a tertiary care hospital in New York

Cited by 16 publications

References 39 publications

Epidemiology of Community-Onset Staphylococcus aureus Bacteremia

Epidemiology of Community-Onset Staphylococcus aureus Bacteremia

Drug-resistance dynamics of Staphylococcus aureus between 2008 and 2014 at a tertiary teaching hospital, Jiangxi Province, China

Prevalence, Characterization, and Drug Resistance of Staphylococcus Aureus in Feces From Pediatric Patients in Guangzhou, China

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