Epidemiology of bone and soft-tissue sarcomas

Beckingsale, Thomas B.; Shaw, C.

doi:10.1016/j.mporth.2017.03.005

Cited by 15 publications

(16 citation statements)

References 14 publications

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“…Occupational exposures that are associated with an increased sarcoma risk include herbicides [3,15,16], phenoxyacetic acid [3], and dioxins from industrial waste incinerators [2]. However, these associations were not observed in some studies in the United States and Sweden [4,17]. Many of the occupational risk factors are not fully established/confirmed because dose dependence has not been observed [2,4,18].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Incidence and Geographic Distribution of Bone and Soft Tissue Sarcomas in Canada: A National Population-Based Study

Alkazemi,

Ghazawi,

Lagacé

et al. 2023

Current Oncology

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Sarcomas are a heterogeneous group of mesenchymal malignancies with various genetic and environmental risk factors. This study analyzed the epidemiology of sarcomas to gain insight into the incidence and mortality rates of these cancers in Canada, as well as to elucidate their potential environmental risk factors. Data for this study were obtained from le Registre Québécois du Cancer (LRQC) and from the Canadian Cancer Registry (CCR) for the period from 1992 to 2010. Mortality data were obtained from the Canadian Vital Statistics (CVS) database for the period from 1992 to 2010 using the International Classification of Diseases for Oncology, ICD-O-3, ICD-9, or ICD-10 codes, for all subtypes of sarcomas. We found that the overall sarcoma incidence in Canada decreased during the study period. However, there were select subtypes with increasing incidence. Peripherally located sarcomas were found to have lower mortality rates compared to axially located sarcomas, as expected. Clustering of Kaposi sarcoma cases in self-identified LGBTQ+ communities and in postal codes with a higher proportion of African-Canadian and Hispanic populations was observed. Forward Sortation Area (FSA) postal codes with a lower socioeconomic status also had higher Kaposi sarcoma incidence rates.

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Section: Introductionmentioning

confidence: 99%

Investigation of the Incidence and Geographic Distribution of Bone and Soft Tissue Sarcomas in Canada: A National Population-Based Study

Alkazemi,

Ghazawi,

Lagacé

et al. 2023

Current Oncology

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“…Tumors that derive from peripheral nerves by convention are also classified as sarcomas, despite their embryological origin in the neural crest. Their great variety is due to the tissues in which they originate, with diverse clinical and biological behavior (Beckingsale and Shaw 2017 ). In Spain, the incidence rate of sarcomas is 18 to 20 cases per million in children, of which 6.5% are STS (Sarcomas en la Infancia 2020 ), with 2.000 total cases/year (Acciones and para que el Gobierno actúe sobre el Sarcoma (plan 2019 – 2020 )).…”

Section: Introductionmentioning

confidence: 99%

“…In the United States (U.S.), 13,130 new STS were diagnosed (7240 males and 5510 females) in 2020 (Key Statistics for Soft Tissue Sarcomas 2019 ). Both sexes are equally affected; the incidence is higher in females in the 45–49 age group, due to gynecological tumors (Beckingsale and Shaw 2017 ; López-Pousa et al 2016 ). Liposarcoma and leiomyosarcoma are the most frequent STS (Francis et al 1996 ; Stiller et al 2013 ; Corey et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical value of baseline 18F-FDG PET/CT in soft tissue sarcomas

Marlés

Fernández

García-Sandoval

et al. 2021

European J Hybrid Imaging

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Background The use of 18F-FDG Positron emission tomography/Computed tomography (PET/CT) in the initial staging of many cancers is clearly established. Most soft tissue sarcoma (STS) has a high affinity for 18F-FDG, which is why 18F-FDG PET/CT has been proposed as a non-invasive method, useful in diagnosis and follow-up. The standardized uptake value values (SUV), the volume-based metabolic parameters MTV (metabolic tumor volume), and TLG (total lesion glycolysis) determine tumor viability and provide its total volume and the total activity of metabolically active tumor cells. The histological grade is the most important predictor of metastases and mortality associated with STS, and a significant relationship between the metabolic parameters of 18F-FDG PET/CT and the histological grade has been described. Methods A retrospective study was conducted on STS patients, who had histological grade according to the FNCLCC (Fédération Nationale des Centres de Lutte Contre Le Cancer) criteria, as well as a baseline PET/CT. SUV (SUVmax, SUVmean, and SUVpeak), MTV, and TLG were quantified. A T-student test was performed to establish the relationship between the metabolic biomarkers and the histological grade. Their usefulness as predictors of the histological grade was verified using receiver operator characteristic (ROC) curves. A survival function study was performed using the Kaplan–Meier method. To assess the prognostic utility of the metabolic biomarkers we use the Log-Rank method. Results The SUV values were useful to discriminate high-grade STS. We found a significant relationship between the histological grade and the SUV values. SUVmax, SUVpeak, MTV, and TLG were predictors of overall survival (OS). There were no significant differences in the OS for the SUVmean, or in the disease-free survival (DFS) for SUVmax, SUVmean, SUVpeak, MTV, and TLG. Conclusions The SUVmax, SUVmean, and SUVpeak values correlate with the HG and are useful to discriminate high-grade from low-grade STS. Patients with high SUVmax, SUVpeak, MTV, and TLG have a significantly lower OS.

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“…Soft tissue sarcomas (STSs) are a diverse group of malignant tumours that originate from mesenchymal tissues. Although their incidence is rising [ 1 ] STSs remain relatively rare, with only 13,100 new cases diagnosed annually in the European Union, equating to just 1% of all new adult cancer diagnoses [ 2 , 3 ]. STSs are classified into two groups based on their genomic characteristics [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Circulating Nucleic Acid Characteristics of Non-Metastatic Soft Tissue Sarcoma Patients

Eastley

Sommer

Ottolini

et al. 2020

IJMS

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Soft tissue sarcomas (STS) are rare, malignant tumours with a generally poor prognosis. Our aim was to explore the potential of cell free DNA (cfDNA) and circulating tumour DNA (ctDNA) analysis to track non-metastatic STS patients undergoing attempted curative treatment. The analysed cohort (n = 29) contained multiple STS subtypes including myxofibrosarcomas, undifferentiated pleomorphic sarcomas, leiomyosarcomas, and dedifferentiated liposarcomas amongst others. Perioperative cfDNA levels trended towards being elevated in patients (p = 0.07), although did not correlate with tumour size, grade, recurrence or subtype, suggesting a limited diagnostic or prognostic role. To characterise ctDNA, an amplicon panel covering three genes commonly mutated in STSs was first trialled on serial plasma collected from nine patients throughout follow-up. This approach only identified ctDNA in 2.5% (one in 40) of the analysed samples. Next custom-designed droplet digital PCR assays and Ion AmpliSeq™ panels were developed to track single nucleotide variants identified in patients’ STSs by whole exome sequencing (1–6 per patient). These approaches identified ctDNA in 17% of patients. Although ctDNA was identified before radiologically detectable recurrence in two cases, the absence of demonstrable ctDNA in 83% of cases highlights the need for much work before circulating nucleic acids can become a useful means to track STS patients.

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Epidemiology of bone and soft-tissue sarcomas

Cited by 15 publications

References 14 publications

Investigation of the Incidence and Geographic Distribution of Bone and Soft Tissue Sarcomas in Canada: A National Population-Based Study

Investigation of the Incidence and Geographic Distribution of Bone and Soft Tissue Sarcomas in Canada: A National Population-Based Study

Clinical value of baseline 18F-FDG PET/CT in soft tissue sarcomas

The Circulating Nucleic Acid Characteristics of Non-Metastatic Soft Tissue Sarcoma Patients

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