Epidemiology of candiduria and Candida urinary tract infections in inpatients and outpatients: results from a 10-year retrospective survey

Gajdács, Márió; Dóczi, Ilona; Ábrók, Marianna; Lázár, Andrea; Burián, Katalin

doi:10.5173/ceju.2019.1909

Cited by 50 publications

(42 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Usually, candiduria is typically asymptomatic and rare in healthy patients, but it is more common in hospitalized patients and especially those in intensive care units (ICU). 1,2 As our previous study indicated, the candiduria incidence rate is as high as 1.61% in hospitalized patients and 22.89% in ICU patients. 3 Diabetes, urinary catheter, female gender, antibiotics, major abdominal surgery and ICU admission are considered as the important risk factors for candiduria.…”

Section: Introductionmentioning

confidence: 93%

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

He¹,

Su²,

Bi³

et al. 2021

IDR

View full text Add to dashboard Cite

Background: Since urine cultures are only guaranteed for patients with obvious urinary symptoms in most cases, most of candiduria episodes are ignored in clinic. Objective: This study aimed to design a screening protocol to improve diagnostic efficiency of candiduria, and provide information of Candida species and drug susceptibility. Methods: All patients, who were admitted to the intensive care unit (ICU) of our hospital during December 1, 2018 and October 1, 2019, were enrolled in this study. Urinalysis was performed every three days for each subject from the first day of ICU admission. Urine specimens were sampled for fungal culture with either condition: (1) yeast-like cell counting (YLCC) ≥200; (2) positive YLCCs were observed in two consecutive tests, and at least one YLCC ≥100. Results: The screening protocol dramatically improved the candiduria diagnostic rate of ICU patients from 2.28% to 17.27%. However, compared to the historical control, the screening protocol has no time-saving advantage in candiduria diagnosing. Higher percentage of C. albicans in screening protocol-identified candiduria patients was observed, although there was no statistical difference. Our results indicated that female gender, pneumonia, diabetes and infarction/hemorrhage patients were more prone to develop candiduria. Non-candiduria patients showed a better tendency for survival and shorter ICU stay length. Multisite colonization was common in the surveyed candiduria patients, who were up to 70.83% showed Candida positive cultures in sputum. Conclusion: The screening protocol established in the study was a convenient and practical tool for early warning and feasible management of candiduria and IC.

show abstract

Section: Introductionmentioning

confidence: 93%

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

He¹,

Su²,

Bi³

et al. 2021

IDR

View full text Add to dashboard Cite

show abstract

“…Усиление колонизации мочевых путей грибами происходит при наличии мочевого дренажа, конкремента в мочевых путях и после антибактериальной терапии [4,10,12,16,35]. Однако влияние антибактериальной терапии как единственного фактора риска усиления колонизации грибами Candida у женщин с неосложненной ИМП не подтвердилось в исследовании R.M.…”

Section: факторы риска кандидоза мочевыводящих путейunclassified

“…Пребывание больного в отделении реанимации и интенсивной терапии является независимым фактором риска развития мочевой инфекции, вызванной Candida spp. [4,16,35]. По данным W. Hu et al, у пациентов в возрасте старше 65 лет с кандидурией повышенный индекс коморбидности Чарлсона, снижение уровня преальбумина и повышение уровня С-реактивного белка должны рассматриваться как дополнительные факторы риска повышенной летальности [16].…”

Section: факторы риска кандидоза мочевыводящих путейunclassified

See 1 more Smart Citation

Risk factors of the fungal urinary tract infections

2021

View full text Add to dashboard Cite

The role of fungi as causative agents of infections is growing. In in-patients, especially at intensive care units, fungal infections might cause serious problems. Studies conducted over recent years shows an increase of fungi detection in urine in in-patients from 5,01 up to 10,63%. Most often, the appearance of fungi in the urine connected with contamination or colonization of the urinary tract. However, in immunocompromised patients, this could be the part of urinary tract infection and even of disseminated fungal process. Candida is the most common cause of fungal urinary tract infections. At the same time, the presence of Candida in urine (candiduria) not always comes with clinical signs of urethritis, cystitis and pyelonephritis. Detection of noCandida albicans agents in urine is increasing, new Candida species revealed are resistant to antifungal drugs so risk of complications is increasing. Recent researches reveal new mechanisms of how Candida interacts with the bacteria that cause urinary infections. The main mechanisms of Candida virulence factors are dimorphism, adhesion proteins — Als1-7,9 and Gls, invasion enzymes — phospholipase, Als3 and Ssa1, as well as enzymes that neutralize reactive oxygen species. The most significant risk factors of fungal urinary tract infection are the presence of a urinary catheter, diabetes mellitus, immunosuppression and previous antibiotic intake. The study of the formation process of the cellular and immune response to Candida makes it possible to identify the main links in the pathogenesis of urinary tract candidiasis, as well as the main role of immunosuppression in the development of the disease.

show abstract

“…It is possible to clinically group patients whose urine presents Candida species: Patients with asymptomatic candiduria (previously healthy, outpatients), patients with asymptomatic candiduria (predisposed inpatients), patients with symptomatic candiduria (UTI), and clinically unstable patients with candiduria [9,10]. Once the presence of Candida in the urine is confirmed, careful clinical evaluation should be performed to detect symptoms or suggestive signs of other conditions, such as diabetes mellitus, genitourinary structural abnormalities, decreased renal function, and metabolic syndromes [9][10][11]. For patients with persistent candiduria, treating certain clinical conditions or removing risk factors is usually sufficient to eliminate the presence of Candida in the urine and no antifungal treatment is required [9].…”

Section: Fungal Urinary Tract Infectionmentioning

confidence: 99%

Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by Candida spp.

Poloni

Rotta

2020

JoF

View full text Add to dashboard Cite

Fungi are pathogenic agents that can also cause disseminated infections involving the kidneys. Besides Candida, other agents like Cryptococcus spp. can cause urinary tract infection (UTI), as well as other non-yeast fungi, especially among immunocompromised patients. The detection and identification of fungi in urine samples (by microscopy and culture) plays an essential role in the diagnosis of fungal UTI. However, variable cutoff definitions and unreliable culture techniques may skew analysis of the incidence and outcome of candiduria. The sediment analysis plays a key role in the identification of fungal UTI because both yeasts and pseudohyphae are easily identified and can be used as a clinical sign of fungal UTI but should not be overinterpreted. Indeed, urine markers of the immune response (leukocytes), urine barriers of tissue protection (epithelial cells), and urine markers of kidney disease (urinary casts) can be found in urine samples. This work explores the manifestations associated with the fungal UTI from the urinalysis perspective, namely the urinary findings and clinical picture of patients with fungal UTI caused by Candida spp., aspects associated with the immune response, and the future perspectives of urinalysis in the diagnosis of this clinical condition.

show abstract

Epidemiology of candiduria and Candida urinary tract infections in inpatients and outpatients: results from a 10-year retrospective survey

Cited by 50 publications

References 25 publications

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

Risk factors of the fungal urinary tract infections

Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by Candida spp.

Contact Info

Product

Resources

About