Epidemiology of Chlamydia trachomatis endocervical infection in a previously unscreened population in Rome, Italy, 2000 to 2009

Marcone, Valentina; Recine, Nadia; Gallinelli, C.; Nicosia, R; Lichtner, Miriam; Degener, Anna Marta; Chiarini, F.; Calzolari, E; Vullo, Vincenzo

doi:10.2807/ese.17.25.20203-en

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…Table S2 (ESM1) shows the detailed characteristics of the selected studies with Ct infection risk estimates in HPV-positive women. Among the 19 selected studies, 9 articles estimate the risk of Ct infection in HPV-positive women without classifiable genotypes (Fogue et al 2018;Enthumathi et al 2015;Panatto et al 2015;Marcone et al 2012;Finan et al 2006;Ta ´bora et al 2005;Baldwin et al 2004;da Silva et al 2004;Tamim et al 2002), 4 consider Ct infection risk in women with HR-HPV infection (Harder et al 2016;Aghaizu et al 2014;Yin et al 2013;Oh et al 2009), 3 consider Ct infection risk among women with infection by HR-HPV and LR-HPV (Safaeian et al 2010;Pereira et al 2010;Franceschi et al 2007), one evaluates the Ct infection risk among women infected with nonclassifiable HPV genotypes, HR-HPV and LR-HPV, single and multiple infection (Molano et al 2003), one considers the Ct infection risk in women with history of non-classifiable HPV genotypes infection (Hwang et al 2014) and one estimates Ct infection risk among women with HR-HPV multiple infections (Quino ´nez-Calvache et al 2016). We classified the studies considering the HPV prevalence (Bruni et al 2010) in the study location: 10 studies were categorized as ''low prevalence countries'' (Harder et al 2016;Panatto et al 2015;Aghaizu et al 2014;Enthumathi et al 2015;Hwang et al 2014;Yin et al 2013;Marcone et al 2012;Oh et al 2009;Finan et al 2006;Tamim et al 2002) and 7 as ''high prevalence countries'' (Fogue et al 2018;Quino ´nez-Calvache e...…”

Section: Selected Studiesmentioning

confidence: 99%

“…Thirteen are cross-sectional studies (Fogue et al 2018;Harder et al 2016;Enthumathi et al 2015;Panatto et al 2015;Aghaizu et al 2014;Yin et al 2013;Marcone et al 2012;Pereira et al 2010;Oh et al 2009;Franceschi et al 2007;Finan et al 2006;Ta ´bora et al 2005;Baldwin et al 2004), 3 are cohort studies (Quino ´nez-Calvache et al 2016;Hwang et al 2014;Molano et al 2003), 2 are case-control studies (da Silva et al 2004;Tamim et al 2002) and 1 is a nested case-control study (Safaeian et al 2010). Ten studies were published until 2010 (Tamim et al 2002;Molano et al 2003;Baldwin et al 2004;da Silva et al 2004;Ta ´bora et al 2005;Finan et al 2006;Franceschi et al 2007;Oh et al 2009;Pereira et al 2010;Safaeian et al 2010) and 9 after 2010 (Marcone et al 2012;Yin et al 2013;Hwang et al 2014;Aghaizu et al 2014;Panatto et al 2015;Enthumathi et al 2015;Quino ´nez-Calvache et al 2016;Harder et al 2016;Fogue et al 2018). Eight studies investigated the risk of chlamydia in HPV-positive women aged less than 36 years …”

Section: Selected Studiesmentioning

confidence: 99%

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Association between human papillomavirus and chlamydia trachomatis infection risk in women: a systematic review and meta-analysis

Naldini

Grisci

Chiavarini

et al. 2019

Int J Public Health

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Objectives Human papillomavirus (HPV) and chlamydia trachomatis (Ct) infection lead to severe consequences for women's health. This meta-analysis summarizes the evidence on HPV infection risk in women with chlamydia and chlamydia risk in HPV-positive women. Methods Medline, Web of Science and Scopus were systematically searched for eligible publications until May 2018. Eligibility criteria included: assessment of HPV/Ct infection; cohort, case-control, cross-sectional study design; and reported risk estimation with its 95% CI for HPV infection in Ct-positive women and/or Ct infection in HPV-positive women. On the PRISMA guidelines, meta-analysis was performed using random effect model. Results Forty-eight studies met the eligibility criteria. Among women with chlamydia, the odds ratio (OR) of HPV infection is 2.12 (95% CI 1.80, 2.49) and the OR of high-risk HPV infection is 2.32 (95% CI 2.02, 2.65). The OR for chlamydia among HPV-positive women is 2.23 (95% CI 1.70, 2.92). Conclusions HPV and Ct behave as reciprocal risk factors. In women diagnosed with HPV infection or chlamydia, the screening for the mutual infection could represent a preventive intervention for severe reproductive health outcomes, such as cervical cancer and infertility.

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Section: Selected Studiesmentioning

confidence: 99%

Section: Selected Studiesmentioning

confidence: 99%

Association between human papillomavirus and chlamydia trachomatis infection risk in women: a systematic review and meta-analysis

Naldini

Grisci

Chiavarini

et al. 2019

Int J Public Health

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“…The susceptibility of all age groups to C. trachomatis infection was also supported by the similar CT incidence among different age groups in our study. In general, C. trachomatis incident cases ( Scott Lamontagne et al, 2007 ; Walker et al, 2012 ; Silver et al, 2015 ) and NAAT-positive detections ( Marcone et al, 2012 ; Sonnenberg et al, 2013 ) are more often found in teenagers (15–19 years) and declined with age thereafter. Two studies based on seroconversions also reported that the highest incidence occurred in those under 26 years in New Zealand ( Righarts et al, 2017 ) and pregnant women under 23 years in Finland ( Lyytikäinen et al, 2008b ).…”

Section: Discussionmentioning

confidence: 99%

“…Genital chlamydia trachomatis (CT) infection is the most common, curable sexually transmitted disease (STD) worldwide ( Woodhall et al, 2018 ). As up to 80% of cases are asymptomatic, CT infection often remains undetected or not diagnosed, which in turn results in the wide spread and delayed treatment of CT infection ( Marcone et al, 2012 ). Furthermore, untreated CT infection can cause scarring of the upper reproductive tract in women and lead to serious complications, such as pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility ( Haggerty et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…Given the significant burden of C. trachomatis infection and the serious sequelae, national C. trachomatis screening program has been implemented mainly targeting young women under 25 years old in several countries including England, Netherlands, and United States ( Marcone et al, 2012 ; Workowski and Bolan, 2015 ) because they usually compose the majority of the reported C. trachomatis new infections ( Fine et al, 2012 ). In these countries, a substantial decrease of CT infection-related complications has been observed at the end of the 1980s and early 1990s and a further decrease of pelvic inflammatory disease and ectopic pregnancy has been documented since 2000 ( Chandra et al, 2005 ; Sutton et al, 2005 ; Bender et al, 2011 ; French et al, 2011 ; Marcone et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Seroepidemiology of Chlamydia trachomatis Infection in the General Population of Northern China: The Jidong Community Cohort Study

et al. 2021

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A longitudinal serological study to investigate the seropositive frequency, incidence, and antibody dynamics of Chlamydia trachomatis infection in the general population of China is urgently needed in order to optimize the strategies for surveillance and precise prevention of C. trachomatis infection. This longitudinal study enrolled 744 subjects aged 18–65 years from Jidong Community of Northern China from 2014 to 2018. Seropositive frequency, incidence, and reinfection of C. trachomatis were determined by detecting antibody against C. trachomatis Pgp3 using “in-house” luciferase immunosorbent assay (LISA). The dynamic of anti-Pgp3 antibody was analyzed using the Generalized Estimating Equation (GEE) model. The overall Pgp3 seropositive frequency among the 18–65-year-old population was 28.1% (95% CI 24.9–31.5), and significantly increased from 12.0% in those aged 18–29 years to 48.6% in the 60–65 years old. The seropositive frequency was slightly higher in women than in men (31.3% vs. 25.4%) without statistical significance. The C. trachomatis incidence and reinfection rate were 11 and 14 per 1,000 person-years, respectively, and showed no significant difference with respect to age, gender, ethnicity, marital status, and education levels. Furthermore, anti-Pgp3 antibody remained detectable in 93.3% (195/209) of the seropositive subjects during the 5 years of follow-up. The overall decay rate for anti-Pgp3 antibody for CT-infected persons was −0.123 Log2 RLU/year, which was dramatically slower than in CT new infection (−3.34 Log2 RLU/year) or reinfection (−1.1 Log2 RLU/year). In conclusion, at least one quarter of the people aged 18–65 years have been infected with C. trachomatis over their lifetime while all age groups are susceptible to C. trachomatis infection in the community of Northern China. Therefore, comprehensive prevention strategies are urgently needed.

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HPV and Chlamydia trachomatis co‐detection in young asymptomatic women from high incidence area for cervical cancer

Bellaminutti

Seraceni

Seta

et al. 2014

Journal of Medical Virology

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Chlamydia trachomatis causing chronic inflammatory diseases has investigated as possible human papillomavirus (HPV) cofactor in cervical cancer. The aim of this study is to evaluate the prevalence of Chlamydia trachomatis and HPV co-infection in different cohorts of asymptomatic women from a Northern Italy area at high incidence for cervical cancer. Cervical samples from 441 females were collected from Cervical Cancer Screening Program, Sexually Transmitted Infectious and Assisted Reproductive Technology centres. HPV and Chlamydia trachomatis were detected simultaneously and genotyped using a highly sensitive bead based assay. The overall prevalence of Chlamydia trachomatis was estimated 9.7%, in contrast with the reported national data of 2.3%, and co-infection with HPV was diagnosed in the 17% of the samples. In females ≤ 25 years of age, the infection reached a peak of 22% and co-infection with HPV of 45.8% (P < 0.001). Of note, in young females diagnosed with low grade cervical lesions, no significant difference between Chlamydia trachomatis and HPV distribution was observed, while differently, HPV co-infection was found significantly associated to the presence of intraepithelial lesions when compared to older females (20% vs. 1%; P < 0.001). In this study, the use of a high sensitive molecular technique exhibited higher analytical sensitivity than the referred assays for the diagnosis of Chlamydia trachomatis and HPV co-infection in asymptomatic females, leading to reduction of the potential to identify incorrectly the infection status. An active screening for timely treatment of Chlamydia trachomatis infection is suggested in young females to evaluate a possible decrease in incidence of pre-cancer intraepithelial lesions.

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Epidemiology of Chlamydia trachomatis endocervical infection in a previously unscreened population in Rome, Italy, 2000 to 2009

Abstract: Binary file ES_Abstracts_Final_ECDC.txt matches

Cited by 13 publications

References 29 publications

Association between human papillomavirus and chlamydia trachomatis infection risk in women: a systematic review and meta-analysis

Association between human papillomavirus and chlamydia trachomatis infection risk in women: a systematic review and meta-analysis

Seroepidemiology of Chlamydia trachomatis Infection in the General Population of Northern China: The Jidong Community Cohort Study

HPV and Chlamydia trachomatis co‐detection in young asymptomatic women from high incidence area for cervical cancer

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