Epidemiology of Chronic Critical Limb Ischemia

Gulati, Akhil; Garcia, Lawrence A.; Acharji, Subasit

doi:10.1007/978-3-319-31991-9_2

Cited by 9 publications

(8 citation statements)

References 25 publications

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“…2, 10 Risk factors for PAD include smoking, hypertension, dyslipidemia, age, gender, and diabetes mellitus. 6, 16 DM is a very important risk factor for PAD due to abnormal conditions in DM such as hyperglycemia, insulin resistance and dyslipidemia, which may trigger the changes in the function and structure of blood vessels. Mechanisms of changes that occur such as increased oxidative stress, impaired intracellular signal transduction by protein kinase C (PKC) and receptor for advanced glycation end-products (RAGE) activation.…”

Section: Case Reportmentioning

confidence: 99%

Emergency thrombectomy in acute upper limb ischemia patient with diabetes mellitus

Arif

Novida

2022

Bali Med J.

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Background: Acute limb ischemia is a sudden decrease in limb blood perfusion with an onset of less than 14 days, most commonly occurs in lower extremities. Diabetes mellitus, one of diseases underlying peripheral artery disease, complicates the pathophysiology of acute limb ischemia. In this case report we present a patient with type 2 diabetes mellitus and acute limb ischemia in the left upper extremity that had successful thrombectomy treatment. Case presentation: A 58-year-old female patient came to the Emergency Care Unit of Dr. Soetomo General Hospital with the continuous pain in the five fingers to the palm of the left hand for the past two days. The numbness spread from the elbow to the left fingers, making them weak and difficult to grip. Those five fingers were pale and cold as well. The left hand had no pulsated radialis and ulnar artery, weak brachial pulse and undetected pulse oximetry result. The patient was diagnosed with type 2 diabetes mellitus since 2005 and has a controlled treatment. On the first day of hospitalization, the patient was scheduled for emergency thrombectomy at Dr. Soetomo General Hospital. Follow-up on the seventh-day post-surgery, the patient had no complaints of pain and pale in the left hand and the brachial, ulnar and radial arteries were palpable. Conclusion: Acute limb ischemia is uncommon in the upper extremities but we found that it has an excellent prognosis with early revascularization, even in a patient with diabetes mellitus. The treatment must be in conjunction with aggressive diabetes mellitus treatment to avoid acute limb ischemia worsening

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Section: Case Reportmentioning

confidence: 99%

Emergency thrombectomy in acute upper limb ischemia patient with diabetes mellitus

Arif

Novida

2022

Bali Med J.

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“…In the case of organic PVD such as arteriosclerosis (one of the most common causes of PVD), the distal blood vessels become narrowed by calcification and plaques, thus decreasing blood flow. On the other hand, in functional PVD such as Raynaud's and Breguars, the distal blood vessels become narrowed due to stress, temperature and environmental causes [22][23]. In either case, organic or functional, the pathophysiology is the same; an increase in tissue metabolic demand without adequate compensation leads to tissue damage.…”

Section: Peripheral Vascular Diseasementioning

confidence: 99%

“…Medications such as analgesics, vasodilators, and anticoagulants offer a dose-limited relief with amputation as the last resort. However, recent studies involving alternative treatment options with SCS have shown to not only reduce pain but also improve distal circulation and resolve ischemic ulcers without amputation [21][22][23]. According to the Cochrane analysis, "all studies showed a trend towards a better amputationfree salvage in the SCS group" as low as p=0.08 in the Spincemaille et al study [25,27].…”

Section: Non Reconstructable Chronic Critical Leg Ischemiamentioning

confidence: 99%

The Effects of Spinal Cord Stimulators on End Organ Perfusion: A Literature Review

Saini

Shnoda

Saini

et al. 2020

Cureus

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“…Suatu penelitian yang dilakukan oleh Medicare dan Medicaid pada tahun 2003 sampai 2008 menemukan bahwa prevalensi terjadinya CLI dalam satu tahun yaitu 2,35% dan insidensi tahunan kasus CLI mencapai 0,35% pada kelompok populasi di atas 40 tahun. [3][4][5] Critical limb ischemia merupakan kondisi medik yang ditandai dengan adanya nyeri iskemik pada saat istirahat yang terjadi dalam waktu lebih dari dua minggu.…”

Section: Pendahuluanunclassified

“…Berdasarkan penelitian yang dilakukan oleh TransAtlantic InterSociety Consensus for the Management of Peripheral Arterial Disease (TASC II) didapatkan bahwa prevalensi kasus CLI lebih tinggi pada laki-laki dibandingkan dengan perempuan dengan rasio 3:1. [3][4][5][6] Pasien merupakan laki-laki yang mengalami nyeri kaki pada saat istirahat dalam jangka waktu selama 3 minggu.…”

Section: Bahasanunclassified

Critical Limb Ischemia: Laporan kasus

Quedarusman¹,

Lasut²

2019

MSJ

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We reported a case of 56 years old man with critical limb ischemia. Diagnosis was made based on anamnesis, signs and clinical symptoms, as well as investigations that included the presence of rest pain in the left leg. Patient also had a history of diabetes mellitus. Echo- doppler and angiographic investigations supported the diagnosis of critical limb ischemia. In this patient, medicamentous treatment has been administered consisted of antiplatelet and cilostazol, blood sugar control by using insulin. The patient also underwent endovascular revascularization.Keywords: critical limb ischemia, peripheral artery diseaseAbstrak: Telah dilaporkan kasus critical limb ischemia pada seorang laki-laki berusia 56 tahun dengan keluhan nyeri seperti terbakar pada kaki kiri bahkan saat istirahat dengan riwayat diabetes melitus. Hasil pemeriksaan penunjang echo-doppler dan angiografi menyokong terdapatnya critical limb ischemia. Diagnosis ditegakkan berdasarkan anamnesis, tanda dan gejala klinis, serta pemeriksaan penunjang. Pada pasien ini, diberikan penatalaksanaan terapi medikamentosa yaitu antiplatelet dan cilostazol, kontrol gula darah dengan menggunakan insulin, dan dilakukan tindakan revaskularisasi endovaskular.Kata kunci: critical limb ischemia, peripheral artery disease

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Epidemiology of Chronic Critical Limb Ischemia

Cited by 9 publications

References 25 publications

Emergency thrombectomy in acute upper limb ischemia patient with diabetes mellitus

Emergency thrombectomy in acute upper limb ischemia patient with diabetes mellitus

The Effects of Spinal Cord Stimulators on End Organ Perfusion: A Literature Review

Critical Limb Ischemia: Laporan kasus

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