Epidemiology of chronic kidney disease in Peru and its relation to social determinants of health

Atamari‐Anahui, Noé; Ccorahua-Ríos, Maycol Suker; Condori-Huaraka, Mirian; Huamanvilca-Yépez, Yerika; Amaya, Elard; Herrera-Añazco, Percy

doi:10.1093/inthealth/ihz071

Cited by 13 publications

(11 citation statements)

References 30 publications

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“…CKD has emerged as a public health concern in Peru due to its increasing mortality and lack of early detection. A study using healthcare and death records from the Peruvian Ministry of Health evidenced an increase of 300% of CKD prevalence between 2010 and 2016, especially in the Tumbes region [ 34 ]. In addition, another study reported that the proportionate mortality due to CKD has also increased in this region during the last 15 years [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

CKD and CKDu in northern Peru: a cross-sectional analysis under the DEGREE protocol

et al. 2021

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Background This study estimated the prevalence and risk factors for decreased estimated glomerular filtration rate (eGFR) in those without known hypertension, type 2 diabetes mellitus, or heavy proteinuria as a surrogate marker for chronic kidney disease of unknown cause (CKDu) among adults in the North of Peru. Methods A cross-sectional study was conducted following the Disadvantaged Populations eGFR Epidemiology (DEGREE) Study protocol. Low eGFR was defined based on a single eGFR ≤60 mL/min/1.7m2 estimated using the CKD-EPI equation. Environmental conditions related to CKDu (i.e., work in agriculture or sugarcane, water source, heat intolerance, and pesticide exposure) were evaluated, in addition to traditional risk factors for CKD (i.e., smoking, heavy drinking, physical activity, hypertension, type 2 diabetes mellitus, urolithiasis, among others). Results A total of 1514 subjects were included in the study, mean age 45.1 (SD: 16.4), and 55.2% were females. Overall, only 26 cases (1.7%; 95%CI: 1.1–2.5%) had an eGFR < 60 mL/min/1.7m2 compatible with CKD definition; when those with hypertension and type-2 diabetes or heavy proteinuria were excluded, according to the DEGREE protocol, the estimate fell to 0.9% (95%CI: 0.4–1.5%). Low physical activity levels (OR = 1.99; 95%CI: 1.18–3.34), hypertension (OR = 2.07; 1.26–3.41), and urolithiasis (OR = 1.97; 95%CI: 1.18–3.27) were factors associated with low eGFR. Conclusions A low population-based prevalence of low eGFR (as a surrogate for CKDu), both in rural and urban settings areas, in the Northern Peru, was found. Low physical activity levels, hypertension and urolithiasis were factors associated with low eGFR. Interventions to prevent CKD cases may be focused on well-known CV risk factors and urolithiasis.

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Section: Discussionmentioning

confidence: 99%

CKD and CKDu in northern Peru: a cross-sectional analysis under the DEGREE protocol

et al. 2021

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“…Public health relevance CKD has emerged as a public health concern in Peru due to its increasing mortality and lack of early detection. A study using healthcare and death records from the Peruvian Ministry of Health evidenced an increase of 300% of CKD prevalence between 2010 and 2016, especially in the Tumbes region [34]. In addition, another study reported that the proportionate mortality due to CKD has also increased in this region during the last 15 years [19].…”

Section: Comparison With Previous Studiesmentioning

confidence: 99%

CKD and CKDu in Northern Peru: a cross-sectional analysis under the DEGREE protocol

Ruíz-Alejos

Caplin

Miranda

et al. 2021

Preprint

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Background: This study estimated the prevalence and risk factors for decreased estimated glomerular filtration rate (eGFR) in those without known hypertension, type 2 diabetes mellitus, or heavy proteinuria as a surrogate marker for chronic kidney disease of unknown cause (CKDu) among adults in the North of Peru.Methods:A cross-sectional study was conducted following the Disadvantaged Populations eGFR Epidemiology (DEGREE) Study protocol. Low eGFR was defined based on a single eGFR ≤60 mL/min/1.7m2 estimated using the CKD-EPI equation. Environmental conditions related to CKDu (i.e., work in agriculture or sugarcane, water source, heat intolerance, and pesticide exposure) were evaluated, in addition to traditional risk factors for CKD (i.e., smoking, heavy drinking, physical activity, hypertension, type 2 diabetes mellitus, urolithiasis, among others).Results:A total of 1514 subjects were included in the study, mean age 45.1 (SD: 16.4), and 55.2% were females. Overall, only 26 cases (1.7%; 95%CI: 1.1% - 2.5%) had an eGFR <60mL/min/1.7m2 compatible with CKD definition; when those with hypertension and type-2 diabetes or heavy proteinuria were excluded, according to the DEGREE protocol, the estimate fell to 0.9% (95%CI: 0.4% - 1.5%). Low physical activity levels (OR = 1.99; 95%CI: 1.18 – 3.34), hypertension (OR = 2.07; 1.26 – 3.41), and urolithiasis (OR = 1.97; 95%CI: 1.18 – 3.27) were factors associated with low eGFR.Conclusions: A low population-based prevalence of low eGFR (as a surrogate for CKDu), both in rural and urban settings areas, in the Northern Peru, was found. Low physical activity levels, hypertension and urolithiasis were factors associated with low eGFR. Interventions to prevent CKD cases may be focused on well-known CV risk factors and urolithiasis.

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“…CKD has emerged as a public health concern in Peru due to its increasing mortality and lack of early detection. A study using healthcare and death records from the Peruvian Ministry of Health evidenced an increase of 300% of CKD prevalence between 2010 and 2016, especially in the Tumbes region [36]. In addition, another study reported that the proportionate mortality due to CKD has also increased in this region during the last 15 years [19].…”

Section: Public Health Relevancementioning

confidence: 99%

CKD and CKDu in Northern Peru: a cross-sectional analysis under the DEGREE protocol

Ruíz-Alejos

Caplin

Miranda

et al. 2020

Preprint

View full text Add to dashboard Cite

Aims: This study estimated the prevalence of low eGFR in those without known hypertension, T2DM or heavy proteinuria as a surrogate marker for chronic kidney disease of unknown cause (CKDu) among adults in the North of Peru. Methods: A cross-sectional study was conducted following the Disadvantaged Populations eGFR Epidemiology (DEGREE) Study protocol. Low eGFR was defined based on a single eGFR ≤ 60 mL/min/1.7 m2 estimated using the CKD-EPI equation. Environmental conditions related to CKDu (i.e. work in agriculture or sugarcane, water source, heat, and pesticide exposure) were evaluated, in addition to traditional risk factors for CKD (i.e. smoking, heavy drinking, physical activity, hypertension, type 2 diabetes mellitus, urolithiasis, among others). Results: A total of 1514 subjects were included in the study, mean age 45.1 (SD: 16.4), and 55.2% were females. Overall, only 26 cases (1.7%; 95%CI: 1.1% − 2.5%) had an eGFR < 60 mL/min/1.7 m2 compatible with CKD definition; when those with hypertension and type-2 diabetes or heavy proteinuria were excluded, according to the DEGREE protocol, the estimate fell to 0.9% (95%CI: 0.4% − 1.5%). Low physical activity levels (OR = 1.99; 95%CI: 1.18–3.34), hypertension (OR = 2.07; 1.26–3.41), and urolithiasis (OR = 1.97; 95%CI: 1.18–3.27) were factors associated with low eGFR. Conclusions: A low population-based prevalence of low eGFR (as a surrogate for CKDu), both in rural and urban settings areas, in the Northern Peru, was found. Low physical activity levels, hypertension and urolithiasis were factors associated with low eGFR. Interventions to prevent CKD cases may be focused on well-known CV risk factors and urolithiasis.

show abstract

Epidemiology of chronic kidney disease in Peru and its relation to social determinants of health

Cited by 13 publications

References 30 publications

CKD and CKDu in northern Peru: a cross-sectional analysis under the DEGREE protocol

CKD and CKDu in northern Peru: a cross-sectional analysis under the DEGREE protocol

CKD and CKDu in Northern Peru: a cross-sectional analysis under the DEGREE protocol

CKD and CKDu in Northern Peru: a cross-sectional analysis under the DEGREE protocol

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