Epidemiology of ciprofloxacin resistance among patients with methicillin-resistant Staphylococcus aureus

Abstract

During the first twelve months after ciprofloxacin was introduced for clinical use at our institution, 65 new patients were found to be either infected or colonized by methicillin-resistant Staphylococcus aureus (MRSA) which were also ciprofloxacin resistant (CR-MRSA). Only 18 of these patients (28%) had been previously exposed to this antibiotic. Nine (50%) of the 18 patients had received ciprofloxacin for treatment for a pathogen other than MRSA. Although the initial cases of colonization or infection with CR-MRSA can be directly related to ciprofloxacin use, many of the subsequent cases of colonization and infection were not the consequence of ciprofloxacin therapy but rather hospital transmission of existing CR-MRSA.

Antibacterial Activity of Hydrophobic Composite Materials Containing a Visible-Light-Sensitive Photocatalyst

“…The data shows a possible approach to lower the incidence of hospital-related bacterial infection, since MRSA is the major pathogenic organism and is frequently resistant to many other agents [22,23]. As has been previously reported, the bactericidal activity of the N-doped TiO 2 -PTFE composite was dependent on the intensity of the visible light and the proportion of N-doped TiO 2 ( Figure 4).…”

Occurrence of quinolone resistance inStaphylococcus aureusfrom nosocomial infection

“…DISCUSSION Development of quinolone-resistance in MRSA was already reported during the investigational period of this antibiotic; there are reports for this development during the course of chemotherapy [15,16]. According to the report by Smith and co-workers [17], the majority of patients with quinolone-resistant MRSA (QR-MRSA) did not receive this antibiotic. Our limited data show that QR-MRSA can also be isolated from patients without quinolone therapy.…”

Corneal Collagen Cross-Linking Using Riboflavin and Ultraviolet-A Irradiation in Keratitis Treatment

“…Also, the antimicrobials currently in use are sometimes problematic because of their toxic effects on the ocular surface (e.g., punctate keratitis, delayed re-epithelialization, hyperemia, chemosis). Nonetheless, emerging patterns of resistance even to these new classes of antimicrobial agents (Daum et al, 1990;Smith et al, 1990;Thomson et al, 1991;Snyder et al 1992;Maffett et al 1993;Chin and Marx, 1994;Fass et al, 1995;Knauf et al, 1996;Garg et al, 1999;Goldstein et al, 1999) have stimulated the continuing quest for an agent that provides rapid and complete microbicidal activity with minimal toxic effects and susceptibility to mechanisms of microbial resistance.…”